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Health & Medicine

Breaking the Hallucinogenic Barrier: Researchers Develop LSD Analogue for Treating Schizophrenia

Researchers have developed a new, neuroplasticity-promoting drug closely related to LSD that harnesses the psychedelic’s therapeutic power with reduced hallucinogenic potential.

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Breaking the Hallucinogenic Barrier: Researchers Develop LSD Analogue for Treating Schizophrenia

Researchers at the University of California, Davis have made a groundbreaking discovery in developing a new drug closely related to LSD. The innovative compound, dubbed JRT, has been designed to harness the therapeutic potential of LSD while minimizing its hallucinogenic effects.

JRT’s development is significant as it may provide a much-needed treatment option for conditions like schizophrenia, where psychedelics are not prescribed due to safety concerns. The research, published in Proceedings of the National Academy of Sciences, highlights JRT’s potential as a treatment for other neuropsychiatric and neurodegenerative diseases characterized by synaptic loss and brain atrophy.

To design JRT, researchers simply flipped the position of two atoms in LSD’s molecular structure. This subtle modification resulted in a significant improvement in JRT’s selectivity profile and reduced its hallucinogenic potential while maintaining its neurotherapeutic properties.

The JRT molecule was named after Jeremy R. Tuck, a former graduate student who synthesized it, and is a testament to the innovative spirit of researchers. David E. Olson, corresponding author and director of the Institute for Psychedelics and Neurotherapeutics at UC Davis, explained that “what we did here is a tire rotation.” By modifying LSD in this way, JRT’s therapeutic potential was unlocked while minimizing its hallucinogenic effects.

JRT exhibited powerful neuroplastic effects and improved measures in mice relevant to the negative and cognitive symptoms of schizophrenia. Importantly, it did not exacerbate behaviors and gene expression associated with psychosis. This makes JRT a promising treatment option for patients where psychedelic use is precluded.

Olson emphasized that JRT’s development emphasizes the potential for using psychedelics as starting points to create better medicines. “We may be able to create medications that can be used in patient populations where psychedelic use is precluded,” he stated.

The researchers conducted a battery of cellular and mouse assays, which demonstrated JRT’s neuroplastic effects and improved safety profile relative to LSD. Key findings included:

* JRT has extremely high therapeutic potential.
* The molecule was tested in other disease models, improving its synthesis, and creating new analogues of JRT that might be even better.

JRT’s potential for treating schizophrenia is significant as most current treatments have limited effects on anhedonia – the inability to feel pleasure – and cognitive function. Clozapine is one exception but has side effects and is not a first-line drug of choice for people severely afflicted with schizophrenia.

Olson and his team are currently testing JRT’s potential against other neurodegenerative and neuropsychiatric diseases, paving the way for further research and development in this area.

Birth Defects

Unconsciousness by Design: How Anesthetics Shift Brainwave Phase to Induce Slumber

A new study finds that an easily measurable brain wave shift of phase may be a universal marker of unconsciousness under general anesthesia.

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Unconsciousness by Design: How Anesthetics Shift Brainwave Phase to Induce Slumber

Scientists have long been fascinated by the mysterious world of unconsciousness, trying to understand what happens in our brains when we fall asleep or are anesthetized. A new study has shed light on this phenomenon, revealing a common thread among different anesthetics: they all induce unconsciousness by shifting brainwave phase.

Ketamine and dexmedetomidine, two distinct anesthetics with different molecular mechanisms, were used in the study to demonstrate how these drugs achieve the same result – inducing unconsciousness. By analyzing brain wave activity, researchers found that both anesthetics push around brain waves, causing them to fall out of phase.

In a conscious state, local groups of neurons in the brain’s cortex can share information to produce cognitive functions such as attention, perception, and reasoning. However, when brain waves become misaligned, these local communications break down, leading to unconsciousness.

The study, led by graduate student Alexandra Bardon, discovered that the way anesthetics shift brainwave phase is a potential signature of unconsciousness that can be measured. This finding has significant implications for anesthesiology care, as it could provide a common new measure for anesthesiologists to ensure patients remain unconscious during surgery.

“If you look at the way phase is shifted in our recordings, you can barely tell which drug it was,” said Earl K. Miller, senior author of the study and Picower Professor. “That’s valuable for medical practice.”

The researchers also found that distance played a crucial role in determining the change in phase alignment. Even across short distances, low-frequency waves moved out of alignment, with a 180-degree shift observed between arrays in the upper and lower regions within a hemisphere.

This study raises many opportunities for follow-up research, including exploring how other anesthetics affect brainwave phase and investigating the role of traveling waves in the phenomenon. Furthermore, understanding the difference between anesthesia-induced unconsciousness and sleep could lead to new insights into the mechanisms that generate consciousness.

In conclusion, this study provides a fascinating glimpse into the world of unconsciousness, revealing a common thread among different anesthetics. By continuing to explore the intricacies of brainwave phase alignment, scientists may uncover more secrets about the mysteries of the human brain.

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Artificial Intelligence

Revolutionizing Rehabilitation with Extended Reality Boccia: A Game-Changer for Older Adults

A team has developed Boccia XR, a rehabilitation program using extended reality technology that can be introduced even in environments with limited space.

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The world of sports has long been fascinated by the unique charm of boccia – a Paralympic game that transcends age and ability barriers. A team from Osaka Metropolitan University has taken this phenomenon a step further with Extended Reality (XR) Boccia, an innovative rehabilitation program that combines physical exercise with emotional benefits for older adults. Developed by Associate Professor Masataka Kataoka’s research group, XR Boccia offers a fresh alternative to traditional boccia and treadmill walking, making it perfect for environments with limited space.

The researchers conducted an intriguing study to investigate the effects of XR Boccia on participants over 65. The findings reveal that both XR Boccia and traditional boccia showed significant improvements in mood, vitality, and energy among participants after experiencing these programs. Notably, there was no substantial difference in lower limb muscle activity during any of the exercises, although a notable increase in rectus femoris muscle activity (which helps extend the knee) was observed in both types of boccia compared to treadmill walking.

The implications of this research are groundbreaking. Associate Professor Kataoka noted that XR Boccia could be an effective rehabilitation exercise for older adults, boasting both physical and emotional benefits. Given its adaptability and practicality, it’s suitable for indoor environments like hospitals and nursing care facilities. The researchers aim to further investigate long-term results in a larger population of older adults and continue updating the XR program.

The study was published in PLOS One, shedding light on this innovative approach to rehabilitation. With XR Boccia, we may be witnessing a new chapter in the journey towards better health and happiness for older adults, one game at a time.

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Diseases and Conditions

“Breaking Isolation: How Addressing Hearing Loss Can Preserve Social Connections Among the Elderly”

Providing hearing aids and advice on their use may preserve social connections that often wane as we age, a new study shows. Its authors say that this approach could help ease the loneliness epidemic that older Americans face.

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Breaking Isolation: How Addressing Hearing Loss Can Preserve Social Connections Among the Elderly

A recent study has shown that providing hearing aids and advice on their use may preserve social connections among older Americans. The researchers found that those who received treatment for hearing loss retained one additional social connection on average over a three-year period compared to those who did not receive any hearing therapies.

The study, led by researchers at NYU Langone Health as part of the ACHIEVE clinical trial, revealed that those given hearing aids had more diverse relationships and maintained deeper bonds than those who were not treated for hearing loss. The findings add to evidence that helping aging patients hear better can enrich their social lives and boost their mental and physical well-being.

Experts have linked both loneliness and hearing loss to depression, heart disease, and early death, among other concerns. A 2023 report on the ACHIEVE trial showed that hearing interventions may slow cognitive decline among those at highest risk for dementia.

The research team collected data about older adults with untreated hearing loss across four sites in Maryland, North Carolina, Minnesota, and Mississippi. The study is among the largest to date to explore if hearing care can help prevent weakening of social networks, having included nearly 1,000 men and women ages 70 through 84.

Half of the participants received hearing aids, counseling sessions, and personalized instruction with an audiologist, while the other half received instruction about exercise, strategies for communicating with healthcare providers, and further resources for healthy aging. To measure social isolation, the researchers assessed how regularly participants spent time with others, the size and variety of their social networks, and the depth of their connections.

Among the findings, the study revealed that before treatment, participants in both groups reported feeling equally lonely. Three years after the intervention took place, loneliness scores slightly improved among those who had received hearing care, while scores slightly worsened among those who did not.

Hearing aids and related audiology appointments cost an average of $4,700, which is usually paid out of pocket, notes Coresh, the founding director of the Optimal Aging Institute. The authors plan to continue following the participants for another three years and to repeat the study with a more diverse group of people.

In conclusion, addressing hearing loss may be a crucial step in preserving social connections among older Americans. By providing hearing aids and related care, we can help alleviate loneliness, improve mental and physical well-being, and potentially slow cognitive decline. As the nation’s social isolation epidemic continues to grow, it is essential that we prioritize hearing health and incorporate hearing aid coverage into Medicare as a means of addressing this critical issue.

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