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Reducing Falls Among Elderly Women with Polypharmacy through Exercise Intervention

An exercise intervention aimed at elderly women was successful at reducing falls, especially among those with polypharmacy, a new study shows.

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The University of Eastern Finland and Kuopio University Hospital recently conducted a study on the effectiveness of exercise interventions aimed at reducing falls among elderly women. The results, published in Scientific Reports, show that an exercise program specifically targeted at women with polypharmacy can significantly reduce the risk of falls.

Polypharmacy was defined as the regular use of four or more medications. The researchers found that women using multiple medications had poorer results in functional tests measuring physical fitness. However, when these women participated in the exercise intervention, they showed a significant improvement in their physical fitness and a substantial reduction in the risk of falls.

The study involved 914 women with a median age of 76.5 years. Half of the participants were randomly assigned to an exercise group that included guided sessions twice a week for six months, followed by free access to recreational sports facilities for another six months. The other half served as a control group.

During the follow-up period, which lasted about two years, 1,380 falls were reported, with 739 resulting in injuries and pain, and 63 in fractures. The researchers found that women who participated in the exercise intervention had a significantly lower risk of fall compared to those in the control group, especially among those using four or more medications.

The results suggest that targeting physical activity specifically at older adults with polypharmacy can be an effective way to enhance fall prevention efforts. As Researcher Anna-Erika Tamminen noted, “Our findings suggest that, in order to enhance fall prevention in the elderly population, efforts to increase physical activity should be targeted specifically at those using multiple medications.”

Overall, the study highlights the importance of exercise interventions tailored to the needs of older adults with polypharmacy and underscores the potential benefits of such programs in reducing falls and improving overall health outcomes.

Alzheimer's Research

The Rise of Dry Eye Disease in Young Adults: A Growing Concern

Researchers have called for more advice to be given to young people about preventing dry eye disease, after a study found that 90% of participants had at least one sign of the condition in their eyes.

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The Rise of Dry Eye Disease in Young Adults: A Growing Concern

Researchers at Aston University have sounded the alarm about the increasing prevalence of dry eye disease among young adults. A recent study conducted in collaboration with Oslo University Hospital and Sørlandet Hospital Trust in Norway has found that a staggering 90% of participants exhibited at least one sign of the condition, with 56% meeting the criteria for dry eye disease.

Dry eye disease occurs when the eyes do not produce enough tears or create poor-quality tears, leading to instability and rapid evaporation of the tear film. This can cause a range of symptoms, including gritty feeling eyes, itching or stinging sensations, redness, sensitivity to light, and blurry vision.

The study, led by Dr. Rachel Casemore at Aston University School of Optometry, followed 50 young adults aged 18-25 over time, assessing their lifestyle factors, screen use habits, and tear quality. The results showed a significant correlation between prolonged screen use and signs of dryness on the eye surface, with participants averaging eight hours per day of screen time.

The researchers found that around half of the participants had lost at least 25% of the meibomian gland, which produces the outer lipid layer of the tear film responsible for preventing evaporation. This loss can contribute to the progression of dry eye disease.

Dr. Casemore emphasized the need for early detection and prevention of dry eye disease in young adults, as it can lead to significant discomfort and vision problems if left unchecked. She recommends simple measures such as taking regular screen breaks, performing blink exercises to release oils from the meibomian glands, staying hydrated, and maintaining a healthy diet rich in omega-3 fatty acids.

The study’s findings highlight the importance of eye care practitioners identifying clinical indicators of dry eye disease and counseling young adults on modifiable risk factors, such as screen use habits, sleeping patterns, contact lens use, diet, blinking patterns, and stress management.

As Dr. Casemore noted, “It is concerning to note the increasing prevalence of dry eye disease signs and symptoms in young adults, which has been referred to as a ‘lifestyle epidemic’ by some researchers.” Further research aims to explore the potential tear and meibomian gland oil biomarkers identified during the study and examine the effect of diet on dry eye disease development.

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Agriculture and Food

The Hidden Risks of Cinnamon: How Your Daily Spice Could Affect Medication

Cinnamon is one of the oldest and most commonly used spices in the world, but a new study indicates a compound in it could interfere with some prescription medications.

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The world’s oldest and most commonly used spice, cinnamon, has been found to have a surprising impact on our bodies. A recent study from the National Center for Natural Products Research indicates that cinnamaldehyde, a primary component of cinnamon, can interfere with some prescription medications. This compound activates receptors that control the metabolic clearance of medication from the body, which means consuming large amounts of cinnamon could reduce the effects of drugs.

According to Shabana Khan, a principal scientist in the center, health concerns could arise if excessive amounts of supplements are consumed without the knowledge of a healthcare provider or prescriber. Overconsumption of supplements could lead to rapid clearance of prescription medicine from the body, making it less effective.

While cinnamon has been used for centuries in traditional medicine and is known to help manage blood sugar and heart health, its actual function in the body remains unclear. Sprinkling cinnamon on your morning coffee is unlikely to cause issues, but using highly concentrated cinnamon as a dietary supplement might.

Not all cinnamon is equal; Cinnamon oil, commonly used topically or as a flavoring agent, presents almost no risk of herb-drug interactions. However, Ground Cassia cinnamon bark, which contains high levels of coumarin, a blood thinner, carries a higher risk. True cinnamon from Sri Lanka has lower coumarin content, making it a safer choice.

The researchers recommend that anyone interested in using cinnamon as a dietary supplement check with their doctor first, especially those suffering from chronic diseases such as hypertension, diabetes, cancer, arthritis, asthma, obesity, HIV, AIDS, or depression.

As Amar Chittiboyina, the center’s associate director, stated, “By definition, supplements are not meant to treat, cure or mitigate any disease.” More research is needed to fully understand the role that cinnamon plays in the body and what potential herb-drug interactions may occur.

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Chronic Illness

Unlocking the Power of Exposomics: Revolutionizing Health Science through Cutting-Edge Technology

Researchers in the field of exposomics explain how cutting-edge technologies are unlocking this biological archive, ushering in a new era of disease prevention and personalized medicine.

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The field of exposomics is revolutionizing health science by unlocking the power of advanced technologies to study the complex interactions between environmental, social, and psychological factors that shape our biology. By analyzing the molecular fingerprints left in our bodies from every breath we take, every meal we eat, and every environment we encounter, researchers are uncovering new insights into disease prevention and personalized medicine.

Led by the Banbury Exposomics Consortium, an interdisciplinary group of scientists gathered at Cold Spring Harbor’s Banbury Center to define the core principles of this rapidly evolving field. Gary Miller, PhD, a foremost expert in exposomics and faculty member at Columbia University Mailman School of Public Health, was the lead organizer of the Consortium.

Exposomics explores how environmental factors such as pollutants in our water and food, social stressors, and psychological factors shape our biology. By studying these combined exposures, researchers can uncover how they collectively influence health, from metabolism and heart function to brain health and disease risk.

The young field is already proving its transformative potential. Researchers analyzing molecular evidence identified a specific industrial solvent as the culprit behind kidney disease clusters among factory workers. In another study, scientists merged satellite pollution mapping with residential location information to reveal how airborne particulates prematurely age the brain.

These discoveries are made possible by cutting-edge technologies and tools such as wearable sensors that track chemical exposures in real-time, satellite imagery that maps pollution down to city blocks, and ultra-sensitive mass spectrometers that detect compounds present at just one part per trillion.

While genetics provides our biological blueprint, it explains only a fraction of chronic disease risk. The exposome captures everything that happens to us, from industrial chemicals to social stressors. Unlike traditional studies examining single exposures in isolation, exposomics integrates advanced tools to understand how environmental, social, and psychological factors collectively interact with our biology.

Systematically analyzing these complex interactions can improve drug development, uncover hidden drivers of disease, and address health disparities. The approach bridges precision medicine and population health.

Miller and colleagues outline critical priorities for advancing exposomics, including the development of more sensitive technologies, creating a human exposome reference to enable analysis and contextualization at the population scale, and implementing standardized protocols to enable AI-driven analysis of complex datasets.

Newly launched U.S. and European exposomics hubs now provide the infrastructure for worldwide collaboration, standardizing methods, harmonizing data, and training researchers in the cross-disciplinary skills needed to advance this field.

“We’re now building the first systematic framework to measure how all exposures — from chemical to social — interact with biology across the lifespan,” says Miller. “Our goal is to create actionable strategies for healthier lives.”

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