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Alcoholism

Heavy Drinking Linked to Signs of Brain Injury, Memory Problems

Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are associated with memory and thinking problems, according to a new study.

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The consumption of eight or more alcoholic drinks per week has been linked to signs of brain injury, including memory and thinking problems. A recent study published in Neurology, the medical journal of the American Academy of Neurology, found that heavy drinkers who consume eight or more drinks per week have a higher risk of developing hyaline arteriolosclerosis, a condition that causes small blood vessels in the brain to narrow.

The study included 1,781 people who had an average age of 75 at death. Researchers examined brain tissue for signs of brain injury, including tau tangles and hyaline arteriolosclerosis. They also measured brain weight and the height of each participant. Family members answered questions about participants’ alcohol consumption.

Researchers divided the participants into four groups: those who never drank, moderate drinkers (seven or fewer drinks per week), heavy drinkers (eight or more drinks per week), and former heavy drinkers. One drink was defined as having 14 grams of alcohol.

The study found that:

* Of those who never drank, 40% had vascular brain lesions.
* Of the moderate drinkers, 45% had vascular brain lesions.
* Of the heavy drinkers, 44% had vascular brain lesions.
* Of the former heavy drinkers, 50% had vascular brain lesions.

After adjusting for factors that could affect brain health such as age at death, smoking, and physical activity, heavy drinkers had 133% higher odds of having vascular brain lesions compared to those who never drank. Former heavy drinkers had 89% higher odds, while moderate drinkers had 60% higher odds.

The study also found that heavy and former heavy drinkers had higher odds of developing tau tangles, a biomarker associated with Alzheimer’s disease, with 41% and 31% higher odds, respectively.

Former heavy drinking was associated with a lower brain mass ratio and worse cognitive abilities. No link was found between moderate or heavy drinking and brain mass ratio or cognitive abilities.

The study’s author noted that impaired cognitive abilities were observed only in former drinkers. Heavy drinkers died an average of 13 years earlier than those who never drank.

In conclusion, the study highlights the importance of understanding the effects of heavy drinking on brain health and implementing preventive measures to reduce heavy drinking. The study was supported by The São Paulo Research Foundation.

Addiction

A New Approach to Reducing College-Aged Drinking Harms: Counter-Attitudinal Advocacy (CAA) Shows Promise

Researchers have developed and tested an intervention called Counter-Attitudinal Advocacy and compared it to to the well-established Personalized Normative Feedback (PNF) to evaluate their effectiveness in decreasing drinks per week, peak blood alcohol concentration and alcohol-related consequences relative to a control group.

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The excessive consumption of alcohol among young adults, particularly college students, poses significant health risks and social consequences. Heavy drinking can lead to blackouts, academic underperformance, interpersonal problems, and secondhand consequences for those who don’t drink, such as interrupted study sessions or having to care for intoxicated peers.

Recently, researchers from Brown University School of Public Health developed an innovative intervention called Counter-Attitudinal Advocacy (CAA). This approach involves advocating for a position that contradicts a personally held attitude or behavior. In the context of college drinking, CAA targets positive perceptions of heavy drinking and the belief that alcohol is an essential part of college life.

A randomized controlled trial at two sites involving 585 college students compared CAA to Personalized Normative Feedback (PNF), a well-established intervention. Researchers focused on drinks per week, a standard measure given the irregular drinking patterns of college students.

The results showed that participants who received PNF reported significantly fewer drinks per week than the control group, while those who received CAA reported significantly fewer consequences related to drinking. Notably, CAA had a harm reduction effect on consequences but not on consumption of alcohol, which it did not target.

According to co-lead investigator Kate Carey, “Both interventions take just 5-10 minutes, making them ideal for broad prevention efforts.” Carey emphasized that PNFs show participants how their drinking habits stack up against those of their peers, often exposing a common misconception that others drink more than they actually do. In contrast, CAA encourages participants to reflect on why it is a good idea to avoid alcohol-related problems and identify specific actions to minimize these risks.

CAA’s personalized approach frames the discussion broadly, focusing on why young people should avoid problems rather than directly telling them what to do. This makes the intervention more engaging and less confrontational. As participants respond to prompts, a research assistant or peer asks them to explain their written responses, which likely strengthens the intervention’s effect.

The researchers stress that having multiple brief interventions is essential since no single approach works for everyone. Offering evidence-based options increases the chances of reaching more people who are undergoing a period of heightened risk. With CAA providing another effective tool, especially for those who may not respond to PNF, this new approach holds promise in reducing college-aged drinking harms.

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Addiction

“The Lasting Impact: How Alcohol Abuse Damages Decision-Making and Brain Function”

For the first time researchers demonstrate in an animal how heavy alcohol use leads to long-term behavioral issues by damaging brain circuits critical for decision-making.

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The Lasting Impact: How Alcohol Abuse Damages Decision-Making and Brain Function

For the first time, researchers have demonstrated in an animal study how heavy alcohol use leads to long-term behavioral issues by damaging brain circuits critical for decision-making. The findings, published in Science Advances, provide a new explanation of alcohol’s long-term effects on cognition.

The Study

In experiments led by research scientist Yifeng Cheng, rats were exposed to high amounts of alcohol for a month. After a nearly three-month withdrawal period, the rats were given a reward-based decision-making test along with a control group that had not been exposed to alcohol. The test was designed to be challenging, requiring memory and strategy to get the most reward.

The Results

The results showed that the alcohol-exposed rats performed considerably worse than the control group. This was due to dramatic functional transformations in the dorsomedial striatum, a part of the brain critical for decision-making. The researchers found that the alcohol had damaged neural circuits causing the rats to process information less effectively.

Long-Term Effects

One surprise was how long alcohol dependence impairs cognition and neural function, even after withdrawal. This may give us insight into why relapse rates for people addicted to alcohol are so high. “Alcohol-induced neural deficits may contribute to decisions to drink even after going to rehab,” said author Patricia Janak.

Future Directions

The researchers next hope to explore how alcoholism affects other areas of the brain that interact with the dorsomedial striatum, and what might be causing the differences between males and females. The study only found behavioral and neural impairments in male rats, but this does not suggest that female rats are immune from the effects of alcohol.

Conclusion

The findings of this study have important implications for our understanding of how alcohol abuse affects brain function and decision-making. By exploring these mechanisms further, we may be able to develop more effective treatments for addiction and improve outcomes for those struggling with substance use disorders.

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