As we age, our bodies undergo various changes that can impact our physical and mental well-being. While some of these changes are inevitable, research suggests that incorporating certain foods into our diet can help promote healthy aging.

A recent study conducted by researchers from Edith Cowan University, Queen’s University Belfast, and Harvard T.H. Chan School of Public Health found that consuming higher intakes of black tea, berries, citrus fruits, and apples could lower the risk of key components of unhealthy aging, including frailty, impaired physical function, and poor mental health.

The study analyzed data from 62,743 women and 23,687 men over a period of 24 years. The findings revealed that women with the highest flavonoid intakes had a 15% lower risk of frailty, a 12% lower risk of impaired physical function, and a 12% lower risk of poor mental health compared to those with the lowest intakes.

While fewer associations were observed in men, higher flavonoid intake was still linked to a lower risk of poor mental health. The researchers suggested that regularly consuming flavonoid-rich foods could support healthier aging by reducing the risk of frailty, physical decline, and poor mental health.

The study’s lead author, Dr. Nicola Bondonno from Edith Cowan University, emphasized the importance of medical research in promoting healthy aging. “Our goal is not just to help people live longer but to ensure they stay healthy for as long as possible,” she said.

Professor Aedin Cassidy from Queen’s University Belfast added that flavonoids have been shown to reduce oxidative stress and inflammation, supporting blood vessel health, and even helping to maintain skeletal muscle mass – all of which are crucial for preventing frailty and maintaining physical function and mental health as we age.

The researchers noted that incorporating three servings of flavonoid-rich food into one’s diet could lead to a 6% to 11% lower risk across all three aging outcomes in females, and a 15% lower risk of poor mental health in males. This highlights the potential for simple dietary modifications to impact overall quality of life and contribute to the optimisation of healthy aging.

Overall, this study underscores the importance of incorporating flavonoid-rich foods into our diet to promote healthier aging. As Professor Eric Rimm from Harvard T.H. Chan School of Public Health noted, “These findings underscore the potential for simple dietary modifications to impact overall quality of life and contribute to the optimisation of healthy aging.”

The Cilento Initiative on Aging Outcomes (CIAO) study has been a decade in the making, and this month, researchers will gather in Acciaroli, Italy to review their progress and plan their next steps. Launched in 2016, the CIAO study seeks to identify key factors that promote healthy aging and extreme longevity.

The region of Cilento in southern Italy is home to a remarkable 300 residents who are over 100 years old and in robust health. This area was also the original source of research for Ancel Keys, the American physiologist who studied the influence of diet on health and promoted the benefits of the Mediterranean diet.

Scientists hope to reveal the longevity secrets of the Cilento region by using an array of tools to measure metabolomics, biomes, cognitive dysfunction, and protein biomarkers for risk of heart disease, Alzheimer’s, kidney disease, and cancer. They will also conduct psychological, social, and lifestyle surveys to gain a more comprehensive understanding.

“There is no single secret to living a long, healthy life,” said Salvatore Di Somma, MD, the study’s lead Italian investigator. “It is many secrets, most of which we are only beginning to understand and more importantly, learn how they might be applied to the well-being of everybody.”

The CIAO study is a multi-institution collaboration that includes Sanford Burnham Prebys, an independent nonprofit biomedical research institute in San Diego, the Sanford Stem Cell Institute at University of California San Diego, University La Sapienza in Rome, and Great Health Science.

A symposium will take place on May 22-23, featuring scientists describing their work and findings. The event is titled “CIAO Study: A decade of science on healthy aging, stem cells, and the revealed secrets of longevity.” Understanding how we age and how we might age better is a timeless pursuit, said David Brenner, MD, president and CEO of Sanford Burnham Prebys.

Current CIAO projects are leveraging genetic, epigenetic, transcriptomic, metabolic, proteomic, and environmental analyses to identify key contributors to extreme longevity. Researchers are using induced pluripotent stem cell (iPSC) derived from the centenarians to model age-related and metabolic stresses in human 3D organoids.

“This study will provide new insights into the development of regenerative medicine strategies for promoting healthy aging and treating age-related conditions,” said Tatiana Kisseleva, MD, PhD, professor of surgery at UC San Diego School of Medicine. Preliminary findings are expected to be presented at the symposium.

The article highlights a groundbreaking discovery made by investigators at Mass General Brigham, who have identified a new pathway that may lead to a treatment for high blood pressure and aortic aneurysms. By creating a novel laboratory model for studying these conditions, the team treated hypertension and aortic aneurysms by targeting a protein called DUSP-3, which they discovered to be involved in the vascular cells’ response to oxidative stress.

Each year, approximately 15,000 Americans die from aortic aneurysms, yet the causes of this condition are incompletely understood. Hypertension affects half of all adults in the country, and there is a large unmet need for the development of new antihypertensive drugs. The researchers’ findings have identified a potentially important and entirely new drug target for the prevention and treatment of hypertension and aortic aneurysms.

To investigate this complex medical condition, Michel and his colleagues created a transgenic mouse model in which oxidative stress can be dynamically modulated within blood vessels using a new scientific strategy termed “chemogenetics.” The studies, led by Apabrita Ayan Das, PhD, a postdoctoral research fellow in the Michel laboratory, found that oxidative stress affected proteins in the blood vessel walls, causing vascular cells to change and become more prone to aneurysms and hypertension.

The research team discovered that one of the key players in this process is DUSP-3. When they gave mice with oxidative stress an inhibitor of DUSP-3, the treatment blocked the development of aortic aneurysms and reduced hypertension. This breakthrough has significant implications for the prevention and treatment of these conditions.

“DUSP-3 had never previously been implicated in hypertension or aneurysm formation,” said Michel. “It could be an important drug target to treat or prevent these conditions.” The researchers are expanding their studies of DUSP-3 inhibition to study other vascular disease states associated with oxidative stress, including Alzheimer’s disease, atherosclerosis, and aging.

This discovery has the potential to revolutionize the treatment of hypertension and aortic aneurysms, and may also lead to new treatments for other complex medical conditions. The researchers’ work highlights the importance of continued scientific investigation into the causes and prevention of these diseases.