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Early Humans

The Pioneers of Pestering Humanity: Uncovering the Evolutionary History of Bed Bugs

Researchers compared the whole genome sequence of two genetically distinct lineages of bed bug, and their findings indicate bed bugs may well be the first true urban pest.

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As we stand at the forefront of modern civilization, it’s hard to imagine that our most unwelcome companions – bed bugs – have been alongside us for over 60,000 years. A recent study led by researchers from Virginia Tech has revealed that bed bugs may be one of the first human pests, with a history that mirrors the expansion and growth of our species.

The researchers compared the whole genome sequence of two genetically distinct lineages of bed bugs: those associated with humans and those with bats. The findings published in Biology Letters suggest that the human-associated lineage has followed a similar demographic pattern as humans, growing exponentially as cities expanded and populations increased.

“This is an exciting discovery because it highlights the co-evolutionary relationship between humans and bed bugs,” said Lindsay Miles, lead author of the study. “We wanted to look at changes in effective population size, which can tell us what’s been happening in their past.”

The historical and evolutionary symbiotic relationship between humans and bed bugs will inform models that predict the spread of pests and diseases under urban population expansion. By directly tying human global expansion to the emergence and evolution of urban pests like bed bugs, researchers may identify the traits that co-evolved in both humans and pests during urban expansion.

In particular, the study highlights the growth of the human-associated lineage as cities expanded into larger settlements around 12,000 years ago. This corresponds with the early establishment of large human settlements that grew into cities such as Mesopotamia.

“It makes sense because modern humans moved out of caves about 60,000 years ago,” said Warren Booth, the Joseph R. and Mary W. Wilson Urban Entomology Associate Professor. “There were bed bugs living in the caves with these humans, and when they moved out they took a subset of the population with them so there’s less genetic diversity in that human-associated lineage.”

The researchers are now interested in further studying this 245,000 year old lineage split, focusing on the evolutionary alterations of the human-associated lineage compared with the bat-associated lineage that have taken place more recently. In particular, they are looking into what happened in the last 100 to 120 years, when bed bugs were thought to be eradicated but started reappearing and resisting pesticides.

The study is a great example of how researchers can “follow the science” and explore new areas of research, thanks in part to the Joseph R. and Mary W. Wilson endowment that supports Booth’s faculty position.

“It’s a great resource to have,” said Booth. “We are using it for work investigating the evolution of insecticide resistance and species spread using museum specimens collected from 120 years ago to our present-day samples. I’m very lucky to have that freedom to explore.”

Ancient Civilizations

Unraveling a 130-Year-Old Literary Mystery: The Song of Wade Finally Solved

After baffling scholars for over a century, Cambridge researchers have reinterpreted the long-lost Song of Wade, revealing it to be a chivalric romance rather than a monster-filled myth. The twist came when “elves” in a medieval sermon were correctly identified as “wolves,” dramatically altering the legend’s tone and context.

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In this groundbreaking study, two scholars from Girton College, Cambridge, present their findings on the Humiliamini sermon, which contains the enigmatic reference to Wade. By analyzing the writing style and arguments presented in the sermon, they conclude that it was likely written by Alexander Neckam or an acolyte familiar with his work.

The sermon’s focus on humility as a lesson in the face of human vices is strikingly relevant today. The researchers highlight the use of vivid animal imagery to convey these themes, including powerful men becoming like wolves and cunning individuals imitating serpents.

Their study sheds new light on the Song of Wade, a medieval literary mystery that has puzzled scholars for over a century. By uncovering its true meaning, this research contributes significantly to our understanding of medieval literature, history, and theology.

As one scholar notes, “This sermon still resonates today… It warns that it’s us, humans, who pose the biggest threat, not monsters.” The retranslation of the Song of Wade offers a powerful reminder of the importance of humility in our daily lives.

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Ancient Civilizations

The Ancient Roots of Disease: Scientists Uncover 214 Prehistoric Pathogens in Human DNA

Scientists have uncovered DNA from 214 ancient pathogens in prehistoric humans, including the oldest known evidence of plague. The findings show zoonotic diseases began spreading around 6,500 years ago, likely triggered by farming and animal domestication. These ancient infections may still influence us today, and help guide the vaccines of tomorrow.

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The Ancient Roots of Disease: Scientists Uncover 214 Prehistoric Pathogens in Human DNA

A groundbreaking study published in Nature has revealed that prehistoric humans were plagued by a staggering 214 ancient pathogens, dating back as far as 6,500 years ago. The research team, led by Professor Eske Willerslev from the University of Copenhagen and the University of Cambridge, analyzed DNA from over 1,300 prehistoric individuals, including those up to 37,000 years old.

This extensive study is the largest to date on the history of infectious diseases and sheds new light on the development of diseases caused by bacteria, viruses, and parasites. The findings suggest that humans’ close cohabitation with domesticated animals, particularly from the Pontic Steppe, played a significant role in the spread of these ancient pathogens.

One of the most striking discoveries is the presence of the plague bacterium Yersinia pestis, which was identified in a 5,500-year-old sample. This is the world’s oldest genetic trace of the disease that ravaged Europe during the Middle Ages, killing between one-quarter and one-half of the population.

The implications of this study are far-reaching and could have significant consequences for vaccine development and our understanding of how diseases arise and mutate over time.

Associate Professor Martin Sikora, the study’s first author, emphasized that “if we understand what happened in the past, it can help us prepare for the future, where many of the newly emerging infectious diseases are predicted to originate from animals.” This knowledge is crucial for developing effective vaccines and ensuring that current ones provide sufficient coverage or need to be updated due to mutations.

The study was made possible by funding from the Lundbeck Foundation. This research highlights the importance of understanding our shared history with ancient pathogens and serves as a reminder of the urgent need to develop targeted solutions for emerging infectious diseases.

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Ancient Civilizations

Unburying the Past: Ancient Footprints Rewrite American History

Footprints found in the ancient lakebeds of White Sands may prove that humans lived in North America 23,000 years ago — much earlier than previously believed. A new study using radiocarbon-dated mud bolsters earlier findings, making it the third line of evidence pointing to this revised timeline.

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The discovery of ancient human footprints in New Mexico’s White Sands National Park has sent shockwaves through the archaeological community. The footprints, estimated to be between 23,000 and 21,000 years old, are rewriting American history by suggesting that humans arrived in the Americas much earlier than previously thought.

Vance Holliday, a University of Arizona archaeologist and geologist, first visited White Sands in 2012 as part of a research project. He was invited to examine the geologic layers in trenches dug by previous researchers, but it wasn’t until he asked about a site on the adjacent missile range that the footprints were discovered.

Researchers from Bournemouth University in the United Kingdom and the U.S. National Park Service excavated the footprints in 2019 and published their findings in 2021. However, critics have questioned the dating of the footprints, citing concerns over the reliability of ancient seeds and pollen used to determine the age.

Undeterred, Holliday led a new study that relied on radiocarbon dating using ancient mud instead of seeds and pollen. The results, published today in Science Advances, confirm that the footprints are between 20,700 and 22,400 years old, corroborating the original finding.

The new study marks the third type of material used to date the footprints, with two separate research groups producing a total of 55 consistent radiocarbon dates. As Holliday notes, “It’s a remarkably consistent record.”

While the discovery is significant, it raises questions about why there are no signs of artifacts or settlements left behind by those who made the footprints. Holliday acknowledges that this remains a mystery, but suggests that hunter-gatherers may have been careful not to leave behind any resources in their short time frame.

The discovery of ancient human footprints in White Sands National Park is rewriting American history and has significant implications for our understanding of when humans first arrived in the Americas. As Holliday says, “You get to the point where it’s really hard to explain all this away.”

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