Connect with us
We’re experimenting with AI-generated content to help deliver information faster and more efficiently.
While we try to keep things accurate, this content is part of an ongoing experiment and may not always be reliable.
Please double-check important details — we’re not responsible for how the information is used.

Ancient DNA

Chemists Recreate a Crucial Step in the Origin of Life

Chemists have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth — a key process in the origin of life.

Avatar photo

Published

on

The origin of life is one of humanity’s greatest mysteries. For centuries, scientists have sought to understand how the complex systems that govern our world emerged from the simple chemistry of the early Earth. A crucial step in this process is the replication of genetic material, which would have been carried by RNA (ribonucleic acid) molecules before DNA and proteins later took over.

Chemists at UCL and the MRC Laboratory of Molecular Biology have made a groundbreaking discovery that brings us closer to understanding how life began. They’ve successfully recreated the conditions under which RNA might have replicated itself on early Earth, a key process in the origin of life.

The researchers used three-letter “triplet” RNA building blocks in water and added acid and heat, which separated the double helix structure that normally prevents RNA strands from replicating. By neutralizing and freezing the solution, they created liquid gaps between the ice crystals where the triplet building blocks could coat the RNA strands and prevent them from zipping back together, allowing replication to occur.

By repeating this cycle of changes in pH and temperature, which could plausibly occur in nature, the researchers were able to replicate RNA over and over again. This process produced RNA strands long enough to have a biological function and play a role in the origin of life.

The study’s lead author, Dr James Attwater, emphasized that replication is fundamental to biology. “In one sense, it is why we are here,” he said. “But there’s no trace in biology of the first replicator.”

The researchers believe that early life was run by RNA molecules, and their findings provide a possible explanation for how this process could have occurred before life began several billion years ago.

While the study focuses solely on the chemistry, the conditions they created could plausibly mimic those in freshwater ponds or lakes, especially in geothermal environments where heat from inside the Earth has reached the surface. However, this replication of RNA could not occur in freezing and thawing saltwater, as the presence of salt interferes with the freezing process and prevents RNA building blocks from reaching the concentration required to replicate RNA strands.

The origin of life is likely to have emerged out of a combination of RNA, peptides, enzymes, and barrier-forming lipids that can protect these ingredients from their environment. The researchers are uncovering clues about how life began, and their findings bring us closer to understanding this fundamental mystery.
In recent years, teams led by Dr John Sutherland and Professor Matthew Powner have demonstrated how chemistry could create many of the key molecules of life’s origin, including nucleotides, amino acids and peptides, simple lipids and precursors to some of the vitamins, from simple molecular building blocks likely abundant on the early Earth.

The latest study was supported by the Medical Research Council (MRC), part of UK Research and Innovation (UKRI), as well as the Royal Society and the Volkswagen Foundation.

Ancient DNA

Unveiling the Dinosaur’s Menu: A Fossilized Time Capsule Reveals the Sauropod’s Diet 100 Million Years Ago

A prehistoric digestive time capsule has been unearthed in Australia: plant fossils found inside a sauropod dinosaur offer the first definitive glimpse into what these giant creatures actually ate. The remarkably preserved gut contents reveal that sauropods were massive, indiscriminate plant-eaters who swallowed leaves, conifer shoots, and even flowering plants without chewing relying on their gut microbes to break it all down.

Avatar photo

Published

on

Unveiling the Dinosaur’s Menu: A Fossilized Time Capsule Reveals the Sauropod’s Diet 100 Million Years Ago

A groundbreaking study published in the Cell Press journal Current Biology has shed light on the diet of one of the most fascinating creatures to have ever walked the Earth – the sauropod dinosaur. The research, led by Stephen Poropat of Curtin University, reveals that these gentle giants were herbivores and had a unique digestive system that relied heavily on gut microbes for digestion.

The study’s findings are based on an extraordinary discovery made in 2017 at the Australian Age of Dinosaurs Museum of Natural History. During an excavation of a sauropod skeleton from the mid-Cretaceous period, researchers stumbled upon a well-preserved cololite – a fossilized rock layer containing the dinosaur’s gut contents.

The analysis of the plant fossils within the cololite has confirmed several long-standing hypotheses about the sauropod diet. The research team found that these dinosaurs likely engaged in minimal oral processing of their food and instead relied on fermentation and their gut microbiota for digestion.

The variety of plants present in the cololite suggests that sauropods were indiscriminate bulk feeders, eating a range of foliage from conifers to leaves from flowering plants. This is supported by the presence of chemical biomarkers from both angiosperms and gymnosperms, indicating that at least some sauropods were not selective feeders.

The researchers’ findings have significant implications for our understanding of these massive herbivores and their role in ancient ecosystems. The study suggests that sauropods had successfully adapted to eat flowering plants within 40 million years of the first evidence of their presence in the fossil record.

In addition, the research team found evidence of small shoots, bracts, and seed pods in the cololite, implying that subadult Diamantinasaurus targeted new growth portions of conifers and seed ferns. This strategy of indiscriminate bulk feeding seems to have served sauropods well for 130 million years and might have enabled their success and longevity as a clade.

While this research has shed new light on the diet of sauropod dinosaurs, there are still limitations to consider. The study’s primary limitation is that the sauropod gut contents described constitute a single data point, which may not be representative of typical or adult sauropods’ diets.

This research was supported by funding from the Australian Research Council and has significant implications for our understanding of these fascinating creatures and their role in ancient ecosystems.

Continue Reading

Ancient DNA

The Tipping Point: Scientists Warn of West Antarctic Ice Sheet Collapse and its Devastating Consequences

Collapse of the West Antarctic Ice Sheet could be triggered with very little ocean warming above present-day, leading to a devastating four meters of global sea level rise to play out over hundreds of years according to a new study. However, the authors emphasize that immediate actions to reduce emissions could still avoid a catastrophic outcome.

Avatar photo

Published

on

The fate of the West Antarctic Ice Sheet (WAIS) hangs precariously in the balance, with scientists warning that the next few years will be crucial in determining its future. A recent study published in Communications Earth & Environment has shed light on the alarming consequences of WAIS collapse, which could trigger a devastating four meters of global sea level rise over hundreds of years.

The researchers from the Potsdam Institute for Climate Impact Research (PIK), NORCE, and Northumbria University in the UK conducted extensive model simulations spanning 800,000 years to understand how the vast Antarctic Ice Sheet has responded to Earth’s climate fluctuations. Their findings revealed two stable states: one with WAIS intact, which is our current state, and another where the ice sheet has collapsed.

The primary driver of this collapse is rising ocean temperatures around Antarctica, which are mostly supplied by the ocean rather than the atmosphere. Once WAIS tips into the collapsed state, it would take several thousands of years for temperatures to drop back to pre-industrial conditions, reversing the damage.

“We have two stable states: one with WAIS intact and another where it has collapsed,” said lead author David Chandler from NORCE. “Once tipping has been triggered, it’s self-sustaining and seems very unlikely to be stopped before contributing to about four meters of sea-level rise. And this would be practically irreversible.”

The consequences of WAIS collapse would be catastrophic, with four meters of sea level rise projected to displace millions of people worldwide and wreak havoc on coastal communities.

However, there is still hope for a better outcome. Immediate actions to reduce emissions could avoid a catastrophic outcome, giving us a narrow window to act before it’s too late.

“It takes tens of thousands of years for an ice sheet to grow, but just decades to destabilise it by burning fossil fuels,” said co-author Julius Garbe from PIK. “Now we only have a narrow window to act.”

Continue Reading

Ancient DNA

Uncovering Ancient Secrets: Dinosaurs Hold Clues to Cancer Discoveries

New techniques used to analyze soft tissue in dinosaur fossils may hold the key to new cancer discoveries. Researchers have analyzed dinosaur fossils using advanced paleoproteomic techniques, a method that holds promise for uncovering molecular data from ancient specimens.

Avatar photo

Published

on

Uncovering Ancient Secrets: Dinosaurs Hold Clues to Cancer Discoveries

A groundbreaking study has discovered that dinosaurs may hold the key to new cancer discoveries. Researchers from Anglia Ruskin University (ARU) and Imperial College London have used advanced paleoproteomic techniques to analyze dinosaur fossils, revealing previously unknown secrets about the evolution of diseases in ancient creatures.

The researchers analyzed a fossilized bone of a Telmatosaurus transsylvanicus, a duck-billed plant-eater that lived between 66-70 million years ago. Using Scanning Electron Microscopy (SEM), they identified low-density structures resembling red blood cells in the fossilized bone. This finding raises the possibility that soft tissue and cellular components are more commonly preserved in ancient remains than previously thought.

By identifying preserved proteins and biomarkers, scientists believe they can gain insights into the diseases that affected prehistoric creatures, including cancer. This has significant implications for future treatments for humans. The authors of the study highlight the importance of prioritizing the collection and preservation of fossilized soft tissue, rather than just dinosaur skeletons, as future advancements in molecular techniques will enable deeper insights into disease evolution.

A previous study had already identified evidence of cancer in Telmatosaurus transsylvanicus, indicating its deep evolutionary roots. Senior author Justin Stebbing, Professor of Biomedical Sciences at Anglia Ruskin University, emphasized the significance of dinosaurs in understanding how species managed cancer susceptibility and resistance over millions of years.

“Dinosaurs, as long-lived, large-bodied organisms, present a compelling case for investigating how species managed cancer susceptibility and resistance over millions of years,” said Stebbing. “Proteins, particularly those found in calcified tissues like bone, are more stable than DNA and are less susceptible to degradation and contamination. This makes them ideal candidates for studying ancient diseases, including cancer, in paleontological specimens.”

The research invites further exploration that could hold the key to future discoveries that could benefit humans. However, it is crucial that long-term fossil conservation efforts are coordinated to ensure that future researchers have access to specimens suitable for cutting-edge molecular investigations.

Continue Reading

Trending