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Alternative Medicine

Ivermectin: The Mosquito-Killing Pill That Dropped Malaria by 26%

A groundbreaking study has revealed that the mass administration of ivermectin—a drug once known for treating river blindness and scabies—can significantly reduce malaria transmission when used in conjunction with bed nets.

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Ivermectin, a drug traditionally used to treat neglected tropical diseases like onchocerciasis and lymphatic filariasis, has been shown to significantly reduce malaria transmission by killing the mosquitoes that feed on treated individuals. Given the rising resistance to conventional insecticides, ivermectin could offer an effective new approach to tackle malaria transmission, especially in regions where traditional methods have become less effective.

The Unitaid-funded BOHEMIA project, which conducted two Mass Drug Administration (MDA) trials in high-burden malaria regions – Kwale County (Kenya) and Mopeia district (Mozambique) – assessed the safety and efficacy of a single monthly dose of ivermectin (400 mcg/kg) given for three consecutive months at the start of the rainy season in reducing malaria transmission. In Kenya, the intervention targeted children aged 5-15, while in Mozambique it focused on children under five.

The results showed a 26% reduction in new malaria infection incidence among children who received ivermectin compared to those who received albendazole, the control drug used in the study. The trial involved over 20,000 participants and more than 56,000 treatments, demonstrating that ivermectin significantly reduced malaria infection rates — particularly among children living further from cluster borders or in areas where drug distribution was more efficient.

The safety profile of ivermectin was favorable, with no severe drug-related adverse events and only mild, transient side effects already seen with ivermectin in campaigns against neglected tropical diseases.

“We are thrilled with these results,” says Carlos Chaccour, co-principal investigator of the BOHEMIA project and ISGlobal researcher at the time of the study. “Ivermectin has shown great promise in reducing malaria transmission and could complement existing control measures. With continued research, ivermectin MDA could become an effective tool for malaria control and even contribute to elimination efforts,” Chaccour adds.

These results align with the World Health Organization’s (WHO) criteria for new vector control tools. The findings suggest that ivermectin MDA could be a valuable complementary strategy for malaria control, particularly in areas where mosquito resistance to insecticides is a growing concern.

Lessons from the Mozambique trial also highlighted the importance of strong community engagement and close collaboration with local authorities in ensuring acceptance of the ivermectin MDA. The study found an important reduction in the prevalence of skin infestations such as scabies and head lice in the ivermectin group in Mozambique, and the community reported a major reduction in bed bugs in Kenya.

In addition to reducing malaria transmission, ivermectin MDA offers significant collateral benefits. The BOHEMIA team found an important reduction in the prevalence of skin infestations such as scabies and head lice in the ivermectin group in Mozambique, and the community reported a major reduction in bed bugs in Kenya.

“This research has the potential to shape the future of malaria prevention, particularly in endemic areas where existing tools are failing,” concludes Regina Rabinovich, BOHEMIA PI and Director of ISGlobal’s Malaria Elimination Initiative. “With its novel mechanism of action and proven safety profile, ivermectin could offer a new approach using a well-known, safe drug that can add to the effect of other mosquito control tools available today.”

Alternative Medicine

A Few Workouts a Week Can Make a Big Difference for Diabetics

Even if you’re cramming your workouts into the weekend, you might be doing your heart a big favor—especially if you have diabetes. A large study of over 50,000 adults with diabetes found that both “weekend warriors” and those who spread out their exercise during the week saw significant reductions in all-cause and cardiovascular mortality risks. Surprisingly, the pattern of exercise didn’t matter as long as the total time met current health guidelines. That means squeezing in your 150 minutes of moderate-to-vigorous physical activity over one or two days can be just as beneficial as spreading it out over several sessions.

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The benefits of regular exercise are well-documented, but a new study suggests that even just two workouts a week can have a significant impact on the health of adults with diabetes. Researchers from several top universities recently published their findings in Annals of Internal Medicine, showing that diabetics who engaged in physical activity had lower risks of heart disease and death compared to those who were inactive.

The study analyzed data from over 51,000 adults with self-reported diabetes who participated in the National Health Interview Survey between 1997 and 2018. The participants were divided into four categories based on their exercise habits: inactive (no reported physical activity), insufficiently active (less than 150 minutes of moderate-to-vigorous physical activity per week), weekend warriors (at least 150 minutes of physical activity, but only on one or two days a week), and regularly active (at least 150 minutes of physical activity, distributed across three or more days a week).

The results were striking. Compared to inactive participants, those who engaged in insufficient physical activity had a 12% lower risk of all-cause mortality and a 15% lower risk of cardiovascular mortality. Weekend warriors had an even greater benefit, with a 21% lower risk of all-cause mortality and a 33% lower risk of cardiovascular mortality. Regularly active participants also saw significant benefits, with a 17% lower risk of all-cause mortality and a 19% lower risk of cardiovascular mortality.

While the study did not find as strong a link between physical activity and cancer mortality, the overall message is clear: any amount of exercise can have a positive impact on the health of adults with diabetes. Whether it’s a quick walk after dinner or a weekend hike, getting moving can make a big difference in reducing the risk of heart disease and death.

So, what are you waiting for? Grab a friend or family member, lace up your shoes, and get out there to enjoy some fresh air and exercise. Your body – and your diabetes – will thank you!

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Alternative Medicine

Unpacking the Obesity Crisis: New Study Reveals Diet Plays Bigger Role Than Physical Activity

People in richer countries aren’t moving less — they’re just eating more. A new Duke study shows that diet, not laziness, is fueling the obesity epidemic across industrialized nations.

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The study conducted by researchers at Duke University’s Pontzer Lab has shed new light on the complex relationship between economic development, daily energy expenditure, and rising obesity rates worldwide. Contrary to the long-held notion that reduced physical activity is the primary driver behind the global obesity crisis, the findings suggest that higher caloric intake is actually the main culprit.

Researchers analyzed data from over 4,200 adults across 34 populations spanning six continents, including hunter-gatherer, pastoralist, farming, and industrialized communities. They found that while daily energy expenditure did decrease marginally with economic development, this factor only explained a small fraction of the increase in body fat accompanying development.

“Diet rather than idleness plays the bigger role in the global obesity crisis,” says Herman Pontzer, principal investigator with the Pontzer Lab and professor in the Department of Evolutionary Anthropology. “Despite decades of trying to understand the root causes of the obesity crisis in economically developed countries, public health guidance remains stuck with uncertainty as to the relative importance of diet and physical activity.”

The study’s results support an emerging consensus that both diet and exercise should be prioritized to tackle the obesity crisis. As Amanda McGrosky, a Duke postdoctoral alumna and lead investigator for the study, notes, “Diet and physical activity should be viewed as essential and complementary, rather than interchangeable.”

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Alternative Medicine

“Pregnancy Shot Cuts Baby RSV Hospitalizations by 72% – Protecting Newborns for Months”

A new UK study shows that vaccinating pregnant women against RSV has led to a staggering 72% drop in hospitalizations of newborns with severe lung infections. By passing virus-fighting antibodies to their babies, vaccinated mothers are helping shield infants during their most vulnerable early months.

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The article reveals groundbreaking research on the effectiveness of vaccinating pregnant women against respiratory syncytial virus (RSV). The study found that babies born to vaccinated mothers had a 72% reduction in hospitalizations due to RSV, making it a crucial tool for reducing infant hospital admissions and pressures on healthcare systems.

Research conducted by universities across England and Scotland involved 537 babies who were admitted to hospital with severe respiratory disease during the winter of 2024-2025. The findings showed that mothers of babies without RSV were more likely to have received the vaccine before delivery, highlighting the importance of timely vaccination for maximum protection.

The study highlights the significance of raising awareness about the availability and effectiveness of the new RSV vaccine, which can be given as early as 28 weeks of pregnancy, allowing for optimal antibody transfer to the baby. However, it is recommended that pregnant women get vaccinated as soon as possible, ideally before delivery, to maximize protection.

The research collaboration also included experts from various institutions and emphasized the value of vaccination in preventing RSV-related illnesses. The study’s findings were published in the journal The Lancet Child and Adolescent Health.

Key Takeaways:

* Vaccinating pregnant women can reduce RSV hospitalizations by 72% among newborns.
* Timely vaccination during pregnancy is crucial for maximum protection against RSV.
* The new RSV vaccine offers a significant opportunity to protect babies from severe respiratory disease.
* Awareness about the availability and effectiveness of the vaccine should be raised among healthcare providers, pregnant women, and their families.

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