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Obesity Impacts the Body’s Reaction Time to Starvation in Mice: A Temporal Disruption

Researchers have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been notoriously laborious and extracting systematic insight from big data has been difficult. Thus, this study paves the way for further research into more general metabolic processes, such as food intake and disease progression.

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Obesity can have far-reaching consequences for our bodies, but new research has revealed an unexpected impact on how we respond to starvation. A study led by Keigo Morita and Shinya Kuroda of the University of Tokyo has discovered that obesity disrupts the “reaction time” of mice when adapting to starvation, despite no significant structural disruptions in the molecular network.

When faced with starvation, our bodies need to adjust their metabolism to survive. This involves coordinating various molecules within cells to extract energy from food and distribute it throughout the body. The liver plays a central role in this process, acting as a sort of “energy manager” that ensures the correct balance of molecules at the right time.

However, the researchers found that obese mice livers responded differently to starvation than healthy mice livers. While the structure of the molecular network remained robust, its temporal coordination was severely disrupted. In other words, the liver’s ability to respond quickly and efficiently to starvation was impaired in obese mice.

The study used a combination of structural and temporal analysis to investigate the intracellular molecular network during starvation. By comparing the livers of healthy and obese mice, they identified clear differences in the hub molecules responsible for regulating metabolic reactions. While healthy mice livers contained energy-related molecules such as ATP and AMP, obese mice livers did not.

The researchers’ findings have significant implications for our understanding of metabolism and disease progression. They suggest that obesity can impact the body’s reaction time to starvation, potentially leading to more severe consequences during times of food scarcity. The study also highlights the importance of considering the temporal dimension in biological research, particularly when studying complex phenomena like metabolic networks.

As Kuroda noted, their approach has opened avenues for further research into more general metabolic processes, such as food intake and disease progression. By combining structural and temporal analysis, researchers can gain a deeper understanding of how our bodies respond to different conditions and develop new insights into the underlying mechanisms driving these responses.

Biodiversity

Unveiling Hidden Gems: Two New Crocodile Species Discovered in Mexico

Biologists have discovered two previously unknown species of crocodiles, one living on the island of Cozumel and the other on the atoll of Banco Chinchorro, both off the Yucat n Peninsula. The findings challenge long-held assumptions about the American crocodile (Crocodylus acutus) and highlight the urgent need for conservation efforts, the researchers say.

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The American crocodile, a species once thought to be widespread across the Caribbean, Central America, and Mexico’s Pacific coast, has been hiding secrets. Researchers from McGill University, in collaboration with Mexican scientists, have made a groundbreaking discovery that challenges long-held assumptions about this iconic creature. Two previously unknown species of crocodiles have been found on the island of Cozumel and the atoll of Banco Chinchorro, both located off the Yucatán Peninsula.

“Biodiversity is disappearing faster than we can discover what we’re losing,” said Biology Professor Hans Larsson, the principal investigator. “Most species of crocodiles are already endangered, and rapid shoreline development threatens nearly every population. Our research aimed to uncover the true diversity of crocodiles on these isolated islands.”

Larsson and his team analyzed the genetic sequences of crocodile populations from Cozumel and Banco Chinchorro. By comparing these sequences to those of crocodiles across the Caribbean, Central America, and Mexico’s Pacific coast, they found striking levels of genetic differentiation, leading them to conclude that these populations were not simply variants of Crocodylus acutus.

“These results were totally unexpected,” former Larsson graduate student and lead author José Avila-Cervantes said. “We assumed Crocodylus acutus was a single species ranging from Baja California to Venezuela and across the Caribbean. Our study is the first to extensively explore genomic and anatomical variation in these animals.”

This discovery has significant conservation implications, as the newly identified species live in small, isolated populations, each numbering fewer than 1,000 breeding individuals. While both populations appear stable, their limited numbers and habitat restrictions make them vulnerable.

“The rapid loss of biodiversity can only be slowed if we know what species are most at risk,” said Larsson. “Now that we recognize these crocodiles as distinct species, it’s crucial to protect their habitats. Limiting land development and implementing careful conservation strategies on Cozumel and Banco Chinchorro will be key to ensuring their survival.”

The research was conducted with the help of local colleagues, including Pierre Charruau at El Colegio de la Frontera Sur in Mexico. The team captured and released crocodiles, collecting blood and scale samples for analysis. Genetic sequencing was carried out at McGill by José Avila-Cervantes during his graduate studies, with additional research on skull morphology by fellow McGill graduate student Hoai-Nam Bui.

This research was funded by the Canadian Foundation for Innovation, the Digital Research Alliance of Canada), the Comisión Nacional para el Conocimiento y Uso de la Biodiversidad, and the Natural Sciences and Engineering Research Council of Canada.

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Biochemistry

Unraveling Nature’s Secret: How Velvet Worm Slime Could Revolutionize Sustainable Materials Design

A new discovery about the slime ejected by velvet worms could revolutionize sustainable material design. The findings outline how a naturally occurring protein structure, conserved across species from Australia, Singapore and Barbados over nearly 400 million years of evolution, enables the slime’s transformation from liquid to fiber and back again. It’s a discovery that could inspire next-generation recyclable bioplastics.

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The discovery of the remarkable properties of velvet worm slime has sent shockwaves through the scientific community, offering new hope for sustainable material design. Researchers from McGill University have made a groundbreaking find that could lead to the development of next-generation recyclable bioplastics.

Velvet worms, small caterpillar-like creatures found in humid forests of the southern hemisphere, possess an extraordinary ability – their slime can transform from liquid to fibre and back again. This remarkable property has puzzled scientists for centuries, but a team led by Matthew Harrington, a chemistry professor and Canada Research Chair in green chemistry, has finally decoded the molecular structure behind this phenomenon.

Using protein sequencing and AI-driven structure prediction (AlphaFold), the researchers identified previously unknown proteins in the slime that function similarly to cell receptors in the immune system. These receptor proteins appear to link large structural proteins during fibre formation, enabling the slime’s remarkable reversibility.

The implications of this discovery are profound. Traditional plastics and synthetic fibres require energy-intensive processes to manufacture and recycle, often involving heat or chemical treatments. In contrast, the velvet worm uses simple mechanical forces – pulling and stretching – to generate strong, durable fibres from biorenewable precursors, which can later be dissolved and reused without harmful byproducts.

While a plastic bottle that dissolves in water may seem like an impractical solution, Harrington believes that adjusting the chemistry of this binding mechanism could overcome this limitation. The team’s next challenge will be to experimentally verify the binding interactions and explore whether the principle can be adapted for engineered materials.

The study was co-authored by researchers from McGill University and Nanyang Technological University (NTU) in Singapore, highlighting the importance of international collaboration in addressing pressing global challenges.

As Harrington aptly puts it, “Nature has already figured out a way to make materials that are both strong and recyclable. By decoding the molecular structure of velvet worm slime, we’re now one step closer to replicating that efficiency for the materials we use every day.”

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Agriculture and Food

The Dark Side of Cannabis Use in Pregnancy

A systematic evidence review finds that consuming cannabis while pregnant appears to increase the odds of preterm birth, low birth weight and infant death.

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The Dark Side of Cannabis Use in Pregnancy

A recent systematic review has raised significant concerns about the risks associated with consuming cannabis while pregnant. The study, conducted by researchers at Oregon Health & Science University, analyzed 51 observational studies involving over 21 million people to examine the potential adverse effects of cannabis use during pregnancy.

The findings are alarming: consuming cannabis appears to increase the odds of preterm birth, low birth weight, and infant death. These results are consistent with definitive evidence in nonhuman primate models exposed to THC, the main psychoactive compound in cannabis.

The placenta, a vital organ responsible for supplying oxygen and nutrients to the fetus, is particularly affected by cannabis use during pregnancy. Research has shown that cannabis can lead to decreased blood flow and reduced availability of oxygen in the placenta, ultimately affecting fetal development and growth.

While many pregnant women may view cannabis as a harmless substance due to its increasingly widespread legalization, the reality is far more concerning. Cannabis remains a Schedule 1 substance under federal law, and its use during pregnancy is not recommended by medical professionals.

The lead author of the study, Dr. Jamie Lo, emphasizes the importance of prioritizing fetal health over any perceived benefits of cannabis use during pregnancy. “Abstinence is ideal,” she notes, “but it’s not realistic for many patients.” In such cases, a harm-reduction approach can be recommended, advising pregnant women to reduce their cannabis consumption and frequency to minimize potential risks.

The research, part of the Systematically Testing the Evidence on Marijuana (STEM) project, highlights the need for more comprehensive studies on the effects of cannabis use during pregnancy. By understanding these risks, healthcare providers can better counsel expectant mothers and promote healthier outcomes for both mother and child.

Sources:

* The study was published in JAMA Pediatrics.
* Funding for this research was provided by the Office of Rural Health in the Veterans Health Administration of the U.S. Department of Veterans Affairs and the National Institute on Drug Abuse of the National Institutes of Health.

Key Takeaways:

* Consuming cannabis during pregnancy appears to increase the odds of preterm birth, low birth weight, and infant death.
* The placenta is particularly affected by cannabis use during pregnancy, leading to decreased blood flow and reduced availability of oxygen.
* A harm-reduction approach can be recommended for pregnant women who cannot abstain from cannabis use.
* More comprehensive studies are needed to fully understand the effects of cannabis use during pregnancy.

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