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Developmental Biology

The Immune System’s Hidden Weakness: How Malaria Parasites Evade Detection

Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body’s immune system, sometimes for years. It turns out that the parasite, Plasmodium falciparum, can shut down a key set of genes, rendering itself ‘immunologically invisible.’

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Researchers at Weill Cornell Medicine have made a groundbreaking discovery that sheds light on why malaria has been so difficult to eradicate. The study, published in Nature Microbiology, reveals how a parasite called Plasmodium falciparum can hide from the body’s immune system, sometimes for years. This finding is crucial in understanding the complexities of malaria and how it affects millions of people worldwide.

Malaria infects 300-500 million people yearly, resulting in nearly 600,000 deaths globally. Current campaigns to control malaria focus on treating people who show symptoms, but this study suggests that asymptomatic adults may also carry potentially transmissible parasites. This revelation means that eliminating malaria from any geographical region will be more complicated than anticipated.

The parasite’s solution to avoiding detection lies in a suite of about 60 genes called var. Each var gene encodes a protein that can insert itself onto the surface of red blood cells, allowing the cell and its resident parasites to adhere to the blood vessel wall and avoid being removed by the spleen. However, this strategy has an inherent flaw: within about a week, the immune system can produce antibodies that recognize the adhesive protein.

To get around this immune counterattack, the parasite shuts off that var gene and expresses a different one from its collection, thereby avoiding detection and prolonging the infection. This paradigm was previously thought to be mutually exclusive, meaning that the parasite always expresses one and only one var gene at a time. However, researchers discovered that some parasites switch on two or three var genes, while others don’t express any at all.

The stealthy parasites that shut down all their var genes were a surprise, as this “null state” would have been impossible to identify using population-based assays. This new aspect of how malaria escapes recognition by the immune system highlights the complexities of the disease and the need for novel strategies in addressing chronic infections.

Dr. Kirk Deitsch plans to conduct fieldwork in West Africa to locate these hidden anatomical reservoirs, which could provide a breakthrough in understanding the problem of chronic malaria infections. This work was supported by the National Institutes of Health and other funding agencies.

Agriculture and Food

The Ozone Secret: Extending Mango Storage Life by 28 Days

Mango lovers and growers alike may soon rejoice: scientists at Edith Cowan University have found that a simple dip in ozonated water can drastically extend the shelf life of mangoes by up to two weeks while reducing spoilage. This technique, called aqueous ozonation, helps prevent chilling injuries that typically occur during cold storage, a long-standing challenge in mango preservation.

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The article highlights groundbreaking research conducted at Edith Cowan University, where scientists have discovered an innovative way to extend the storage life of mangoes by up to 28 days. Led by Dr Mekhala Vithana, the study reveals that dipping mangoes in ozonated water for 10 minutes before cold storage significantly reduces chilling injury and extends shelf life.

Mango lovers rejoice! The research is a game-changer for growers and traders alike, as it reduces food loss during storage and provides a longer market window. With the global demand for fruits and vegetables on the rise, this eco-friendly technology could minimize post-harvest losses of mangoes and reduce waste in Australia.

Traditionally, mangoes are stored at 13 degrees Celsius for up to 14 days, but this temperature is not cold enough to prevent chilling injury. Prolonged storage below 12.5 degrees causes physiological disorders that damage the fruit skin and lead to decreased marketability and significant food waste.

The study tested aqueous ozonation technology on Australia’s most widely produced mango variety, Kensington Pride, and found that dipping the mango in ozonated water for 10 minutes prior to cold storage at 5 degrees Celsius extended shelf life up to 28 days with much less chilling injury. This breakthrough could revolutionize the way we store mangoes and reduce food waste.

Dr Vithana emphasizes that aqueous ozonation is a cost-effective, controlled-on-site technology that can be used in commercial settings. The researchers hope to conduct further studies on other varieties of mangoes to test their responsiveness and achieve further reduction in chilling injury for extended cold storage.

As we continue to explore innovative solutions to reduce food waste, the ozone secret could hold the key to extending mango storage life by 28 days, benefiting both growers and consumers alike.

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Biochemistry Research

The Whispering Womb: Uncovering the Secret Language of Embryonic Cells

Scientists found that embryonic skin cells “whisper” through faint mechanical tugs, using the same force-sensing proteins that make our ears ultrasensitive. By syncing these micro-movements, the cells choreograph the embryo’s shape, a dance captured with AI-powered imaging and computer models. Blocking the cells’ ability to feel the whispers stalls development, hinting that life’s first instructions are mechanical. The discovery suggests hearing hijacked an ancient force-sensing toolkit originally meant for building bodies.

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The human body begins as a single cell that multiplies and differentiates into thousands of specialized cells. Researchers at the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN) and the Max Planck Institute have made a groundbreaking discovery: embryonic cells “listen” to each other through molecular mechanisms previously known only from hearing.

Using an interdisciplinary approach combining developmental genetics, brain research, hearing research, and theoretical physics, the researchers found that in thin layers of skin, cells register the movements of their neighboring cells and synchronize their own tiny movements with those of the others. This coordination allows groups of neighboring cells to pull together with greater force, making them highly sensitive and able to respond quickly and flexibly.

The researchers created computer models of tissue development, which showed that this “whispering” among neighboring cells leads to an intricate choreography of the entire tissue, protecting it from external forces. These findings were confirmed by video recordings of embryonic development and further experiments.

Dr. Matthias Häring, group leader at the CIDBN, explained that using AI methods and computer-assisted analysis allowed them to examine about a hundred times more cell pairs than was previously possible in this field, giving their results high accuracy.

The mechanisms revealed in embryonic development are also known to play a role in hearing, where hair cells convert sound waves into nerve signals. The ear is sensitive because of special proteins that convert mechanical forces into electrical currents. This discovery suggests that such sensors of force may have evolved from our single-celled ancestors, which emerged long before the origin of animal life.

Professor Fred Wolf, Director of the CIDBN, noted that future work should determine whether the original function of these cellular “nanomachines” was to perceive forces inside the body rather than perceiving the outside world. This phenomenon could provide insights into how force perception at a cellular level has evolved.

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Cell Biology

A 600-Million-Year-Old Body Blueprint Uncovered in Sea Anemones

Sea anemones may hold the key to the ancient origins of body symmetry. A study from the University of Vienna shows they use a molecular mechanism known as BMP shuttling, once thought unique to bilaterally symmetrical animals like humans, insects, and worms. This surprising discovery implies that the blueprint for forming a back-to-belly body axis could date back over 600 million years, to a common ancestor of cnidarians and bilaterians.

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A new study from the University of Vienna has made a groundbreaking discovery in the field of developmental biology. Researchers have found that sea anemones, traditionally considered radially symmetric animals, use a molecular mechanism known as BMP shuttling to pattern their back-to-belly body axis. This finding suggests that bilateral symmetry, which characterizes a vast group of animals including vertebrates, insects, and worms, may have evolved much earlier than previously assumed.

BMP shuttling is a signaling system involving Bone Morphogenetic Proteins (BMPs) and their inhibitor Chordin. In bilaterian animals, this mechanism creates a gradient of BMP activity across the embryo, allowing cells to detect and adopt different fates depending on BMP levels. The study’s findings indicate that sea anemones use BMP shuttling in a similar manner, with cells expressing different fates based on BMP signaling.

To investigate whether sea anemones indeed use BMP shuttling, researchers blocked Chordin production in the embryos of the model sea anemone Nematostella vectensis. Without Chordin, BMP signaling ceased, and the formation of the second body axis failed. However, when Chordin was reintroduced into a small part of the embryo, BMP signaling resumed – but only with a diffusible form of Chordin, which acts as a BMP shuttle.

The presence of BMP shuttling in both cnidarians and bilaterians suggests that this molecular mechanism predates their evolutionary divergence some 600-700 million years ago. The study’s findings open up exciting possibilities for rethinking how body plans evolved in early animals, and may have significant implications for our understanding of the evolution of bilateral symmetry.

The research was supported by the Austrian Science Fund (FWF), grants P32705 and M3291.

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