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Ancient Civilizations

Unlocking the Secrets of Ancient Human Remains: A New Method for Accessing Proteins in Soft Tissues

A new method could soon unlock the vast repository of biological information held in the proteins of ancient soft tissues. The findings could open up a new era for palaeobiological discovery.

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The article you provided is a fascinating study on a groundbreaking method for extracting and identifying proteins from ancient human soft tissues. Here’s a rewritten version, maintaining the core ideas but improving clarity, structure, and style:

Unlocking the Secrets of Ancient Human Remains: A New Method for Accessing Proteins in Soft Tissues

A team of researchers at the University of Oxford has developed a revolutionary method that could soon unlock the vast repository of biological information held in the proteins of ancient human soft tissues. This discovery, published in PLOS ONE, opens up a new era for palaeobiological discovery and promises to vastly expand our understanding of ancient diet, disease, environment, and evolutionary relationships.

Up until now, studies on ancient proteins have been confined largely to mineralized tissues such as bones and teeth. However, the internal organs – which are a far richer source of biological information – have remained inaccessible due to the lack of an established protocol for their analysis. This new method changes that.

A key hurdle was finding an effective way to disrupt cell membranes to liberate proteins. The team discovered that urea successfully broke open cells and released proteins within. After extraction, the proteins were then separated using liquid chromatography and identified using mass spectrometry. By coupling this step with high-field asymmetric-waveform ion mobility spectrometry (which separates ions based on how they move in an electric field), the researchers found that they could increase the number of proteins identified by up to 40%.

This technique makes it possible to recover proteins from samples that are hard to analyze, including degraded or very complex mixtures. The team was able to identify over 1,200 ancient proteins from just 2.5 mg of sample – a feat that has never been achieved before.

Using the combined method, the researchers identified a diverse array of proteins that govern healthy brain function, reflecting the molecular complexity of the human nervous system. They also identified potential biomarkers for neurological diseases such as Alzheimer’s and multiple sclerosis. This new technique opens a window on human history we haven’t looked through before.

The vast majority of human diseases – including psychiatric illness and mental health disorders – leave no marks on the bone, making them essentially invisible in the archaeological record. This discovery promises to transform our understanding of ancient human health and disease.

Senior author Professor Roman Fischer, Centre for Medicines Discovery at the University of Oxford, added: “By enabling the retrieval of protein biomarkers from ancient soft tissues, this workflow allows us to investigate pathology beyond the skeleton, transforming our ability to understand the health of past populations.”

This method has already attracted interest for its applicability to a wide range of archaeological materials and environments – from mummified remains to bog bodies, and from antibodies to peptide hormones. As Dr Christiana Scheib, Department of Zoology at the University of Cambridge, noted: “Ancient soft tissues are so rarely preserved, yet could hold such powerful information regarding evolutionary history.”

Ancient Civilizations

“Uncovering Ancient Culinary Traditions: The Butchery Secrets of Our Prehistoric Ancestors”

Neanderthals living just 70 kilometers apart in Israel may have had different food prep customs, according to new research on butchered animal bones. These subtle variations — like how meat was cut and cooked — hint at cultural traditions passed down through generations. The findings challenge the idea that Neanderthal life was purely practical, suggesting instead a richer, more social layer to their culinary habits.

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“Uncovering Ancient Culinary Traditions: The Butchery Secrets of Our Prehistoric Ancestors

Scientists have long been fascinated by the mysterious lives of our prehistoric ancestors, the Neanderthals. Recently, a new study has shed light on an intriguing aspect of their daily life – their culinary traditions. Researchers have discovered that two groups of Neanderthals living in close proximity to each other, yet exhibiting distinct cultural practices, had different ways of butchering and preparing food.

The study, published in Frontiers in Environmental Archaeology, focused on the caves of Amud and Kebara in northern Israel, where Neanderthals resided during the winters between 50 and 60,000 years ago. Despite sharing similar living conditions and tools, the two groups developed unique butchery strategies, which may have been passed down through social learning and cultural traditions.

One of the key findings was that the Neanderthals at Amud seem to have hunted more small prey than those at Kebara, who had a preference for larger game. This difference in hunting practices led to distinct patterns in food preparation. The bones at Amud were mostly burned and fragmented, suggesting deliberate actions like cooking or accidental damage. In contrast, the bones at Kebara showed less fragmentation and were thought to have been cooked.

The researchers selected a sample of cut-marked bones from contemporaneous layers at the two sites and examined them macroscopically and microscopically. They found that the cut-marks were clear and intact, largely unaffected by later damage caused by carnivores or the drying out of the bones. However, the profiles, angles, and surface widths of these cuts were similar, likely due to the two groups’ similar toolkits.

The key difference between the two sites lay in the density and linearity of the cut-marks. Those at Amud were more densely packed and less linear in shape than those at Kebara. Experimental archaeology suggested that this pattern couldn’t be accounted for by less skilled butchers or by butchering more intensively to get as much food as possible.

The researchers proposed several explanations for these findings, including the possibility that the Neanderthals at Amud were treating meat differently before butchering it – possibly drying their meat or letting it decompose. Another possibility was that different group organization played a role, such as the number of butchers who worked on a given kill.

While more research is needed to investigate these possibilities, this study provides valuable insights into the culinary traditions of our prehistoric ancestors and highlights the importance of considering cultural practices in understanding their daily lives.

As Anaëlle Jallon, PhD candidate at the Hebrew University of Jerusalem and lead author of the article, noted, “There are some limitations to consider… Future studies, including more experimental work and comparative analyses, will be crucial for addressing these uncertainties – and maybe one day reconstructing Neanderthals’ recipes.”

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Ancient Civilizations

Unraveling a 130-Year-Old Literary Mystery: The Song of Wade Finally Solved

After baffling scholars for over a century, Cambridge researchers have reinterpreted the long-lost Song of Wade, revealing it to be a chivalric romance rather than a monster-filled myth. The twist came when “elves” in a medieval sermon were correctly identified as “wolves,” dramatically altering the legend’s tone and context.

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In this groundbreaking study, two scholars from Girton College, Cambridge, present their findings on the Humiliamini sermon, which contains the enigmatic reference to Wade. By analyzing the writing style and arguments presented in the sermon, they conclude that it was likely written by Alexander Neckam or an acolyte familiar with his work.

The sermon’s focus on humility as a lesson in the face of human vices is strikingly relevant today. The researchers highlight the use of vivid animal imagery to convey these themes, including powerful men becoming like wolves and cunning individuals imitating serpents.

Their study sheds new light on the Song of Wade, a medieval literary mystery that has puzzled scholars for over a century. By uncovering its true meaning, this research contributes significantly to our understanding of medieval literature, history, and theology.

As one scholar notes, “This sermon still resonates today… It warns that it’s us, humans, who pose the biggest threat, not monsters.” The retranslation of the Song of Wade offers a powerful reminder of the importance of humility in our daily lives.

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Ancient Civilizations

Uncovering Ancient Histories: Princeton Study Reveals 200,000 Years of Human-Neanderthal Interbreeding

For centuries, we’ve imagined Neanderthals as distant cousins — a separate species that vanished long ago. But thanks to AI-powered genetic research, scientists have revealed a far more entangled history. Modern humans and Neanderthals didn’t just cross paths; they repeatedly interbred, shared genes, and even merged populations over nearly 250,000 years. These revelations suggest that Neanderthals never truly disappeared — they were absorbed. Their legacy lives on in our DNA, reshaping our understanding of what it means to be human.

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[Image description: A sun-kissed landscape with towering trees, sparkling rivers, and vast plains stretching out to the horizon. In the foreground, a group of early humans are seen huddled around a fire, roasting meat on skewers while others are busy gathering fruits and berries from nearby bushes. Nearby, a Neanderthal individual is spotted, using a crude stone tool to scrape off flesh from a freshly hunted mammoth carcass. The two groups seem to be living in harmony, with some members of each group occasionally interacting and exchanging goods or stories.]

The Princeton study, led by Joshua Akey, has uncovered new layers of the shared history between early humans and Neanderthals. Using a genetic tool called IBDmix, the researchers mapped gene flow between the hominin groups over the past quarter-million years, revealing multiple waves of contact and interbreeding.

“We now know that for the vast majority of human history, we’ve had a history of contact between modern humans and Neanderthals,” said Akey. The results of their work were published in the journal Science, challenging previous genetic data that suggested modern humans evolved in Africa 250,000 years ago and then dispersed out of Africa 50,000 years ago.

The study found evidence of three main waves of contact: one about 200-250,000 years ago, another around 100-120,000 years ago, and the largest wave about 50-60,000 years ago. This contrasts sharply with previous research that suggested modern humans stayed put in Africa for 200,000 years before dispersing out.

The researchers also discovered that Neanderthals had a smaller population than previously thought, with estimates revised from around 3,400 individuals to roughly 2,400. This finding helps explain how Neanderthals disappeared from the fossil and genetic record around 30,000 years ago.

Akey’s team found strong evidence consistent with Fred Smith’s hypothesis that Neanderthals were largely absorbed into modern human communities rather than going extinct. “Our results provide strong genetic data consistent with Fred’s hypothesis, and I think that’s really interesting,” said Akey.

The study provides a new understanding of the complex relationship between early humans and Neanderthals, highlighting the importance of interbreeding and cultural exchange in shaping human evolution.

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