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Ancient Civilizations

Unlocking the Secrets of Ancient Human Remains: A New Method for Accessing Proteins in Soft Tissues

A new method could soon unlock the vast repository of biological information held in the proteins of ancient soft tissues. The findings could open up a new era for palaeobiological discovery.

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The article you provided is a fascinating study on a groundbreaking method for extracting and identifying proteins from ancient human soft tissues. Here’s a rewritten version, maintaining the core ideas but improving clarity, structure, and style:

Unlocking the Secrets of Ancient Human Remains: A New Method for Accessing Proteins in Soft Tissues

A team of researchers at the University of Oxford has developed a revolutionary method that could soon unlock the vast repository of biological information held in the proteins of ancient human soft tissues. This discovery, published in PLOS ONE, opens up a new era for palaeobiological discovery and promises to vastly expand our understanding of ancient diet, disease, environment, and evolutionary relationships.

Up until now, studies on ancient proteins have been confined largely to mineralized tissues such as bones and teeth. However, the internal organs – which are a far richer source of biological information – have remained inaccessible due to the lack of an established protocol for their analysis. This new method changes that.

A key hurdle was finding an effective way to disrupt cell membranes to liberate proteins. The team discovered that urea successfully broke open cells and released proteins within. After extraction, the proteins were then separated using liquid chromatography and identified using mass spectrometry. By coupling this step with high-field asymmetric-waveform ion mobility spectrometry (which separates ions based on how they move in an electric field), the researchers found that they could increase the number of proteins identified by up to 40%.

This technique makes it possible to recover proteins from samples that are hard to analyze, including degraded or very complex mixtures. The team was able to identify over 1,200 ancient proteins from just 2.5 mg of sample – a feat that has never been achieved before.

Using the combined method, the researchers identified a diverse array of proteins that govern healthy brain function, reflecting the molecular complexity of the human nervous system. They also identified potential biomarkers for neurological diseases such as Alzheimer’s and multiple sclerosis. This new technique opens a window on human history we haven’t looked through before.

The vast majority of human diseases – including psychiatric illness and mental health disorders – leave no marks on the bone, making them essentially invisible in the archaeological record. This discovery promises to transform our understanding of ancient human health and disease.

Senior author Professor Roman Fischer, Centre for Medicines Discovery at the University of Oxford, added: “By enabling the retrieval of protein biomarkers from ancient soft tissues, this workflow allows us to investigate pathology beyond the skeleton, transforming our ability to understand the health of past populations.”

This method has already attracted interest for its applicability to a wide range of archaeological materials and environments – from mummified remains to bog bodies, and from antibodies to peptide hormones. As Dr Christiana Scheib, Department of Zoology at the University of Cambridge, noted: “Ancient soft tissues are so rarely preserved, yet could hold such powerful information regarding evolutionary history.”

Ancient Civilizations

“Uncovering Neanderthals’ Ancient Superhighways: A 2,000-Mile Journey Across Eurasia”

Neanderthals may have trekked thousands of miles across Eurasia much faster than we ever imagined. New computer simulations suggest they used river valleys like natural highways to cross daunting landscapes during warmer climate windows. These findings not only help solve a long-standing archaeological mystery but also point to the likelihood of encounters and interbreeding with other ancient human species like the Denisovans.

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A new study by a team of anthropologists has shed light on the mysterious migration routes of Neanderthals across Eurasia. Using computer simulations, researchers Emily Coco and Radu Iovita have created a map of possible pathways that suggest these ancient humans traveled approximately 2,000 miles (3,250 km) in less than 2,000 years.

The study reveals that Neanderthals likely used river valleys as natural highways to traverse the vast distances between Eastern Europe and Central Eurasia. The researchers considered factors such as terrain elevation, reconstructed ancient rivers, glacial barriers, and temperature when modeling the movement decisions of individual Neanderthals.

Two ancient periods were identified as prime migration windows: Marine Isotope Stage 5e (MIS 5e), beginning approximately 125,000 years ago, and Marine Isotope Stage 3 (MIS 3), starting around 60,000 years ago. Both periods featured warmer temperatures, making it easier for Neanderthals to move across the landscape.

Computer simulations conducted on the NYU Greene Supercomputer Cluster indicated that Neanderthals could have reached the Siberian Altai Mountains within 2,000 years during either MIS 5e or MIS 3 by following multiple possible routes. These routes often intersected with known archaeological sites from the same time periods, providing a tangible link to the past.

The study provides important insights into Neanderthal interactions with other ancient human groups. The researchers note that their migration routes would have taken them into areas already occupied by Denisovans, consistent with existing evidence of interbreeding between the two species.

According to Iovita, “Neanderthals could have migrated thousands of kilometers from the Caucasus Mountains to Siberia in just 2,000 years by following river corridors.” This finding highlights the adaptability and resilience of these ancient humans, who were able to navigate challenging landscapes and establish themselves across vast distances.

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Ancient Civilizations

Uncovering Ancient Native American Farms in Michigan: A Drone-Based Study Reveals 1,000-Year-Old Farming System

In the dense forests of Michigan s Upper Peninsula, archaeologists have uncovered a massive ancient agricultural system that rewrites what we thought we knew about Native American farming. Dating back as far as the 10th century, the raised ridged fields built by the ancestors of the Menominee Indian Tribe covered a vast area and were used for cultivating staple crops like corn and squash. Using drone-mounted lidar and excavations, researchers found evidence of a complex and labor-intensive system, defying the stereotype that small, egalitarian societies lacked such agricultural sophistication. Alongside farming ridges, they also discovered burial mounds, dance rings, and possible colonial-era foundations, hinting at a once-thriving cultural landscape previously obscured by forest.

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The Dartmouth-led study has made a groundbreaking discovery in Michigan’s Upper Peninsula, uncovering a 1,000-year-old Native American farm system that challenges preconceived ideas about agriculture in the region. The Sixty Islands archaeological site along the Menominee River features a raised ridge field system dating back to around the 10th century to 1600. This is the most complete ancient agricultural site in the eastern half of the United States.

The researchers surveyed approximately 330 acres using drone-based lidar, which provided a dataset that revealed clusters of ridged garden beds ranging from 4 to 12 inches in height. These raised fields were used by ancestors of the Menominee Indian Tribe of Wisconsin to grow corn, beans, squash, and other plants.

Lead author Madeleine McLeester noted that the scale of this agricultural system is 10 times larger than previously estimated, forcing a reconsideration of preconceived ideas about agriculture in the region and globally. The team’s findings also suggest that the ancestral Menominee communities were modifying the soil to rework the topography, using wetland soils to enrich the soil and remain from fires as compost.

The researchers conducted excavations at the site, recovering charcoal, broken ceramics, and artifacts, which suggested that remains from fires and household refuse were likely used as compost in the fields. The results showed that the farming system was a massive undertaking requiring organization, labor, and know-how to maximize agricultural productivity.

The findings have significant implications for our understanding of ancient agriculture in eastern North America and challenge existing forest history of the Upper Peninsula. The team is continuing their work with the Menominee Indian Tribe of Wisconsin at the Menominee Sixty Islands site, planning to survey the site and locate ancestral Menominee villages.

This study demonstrates the importance of innovative technologies like drone-based lidar in uncovering hidden archaeological features and provides a unique window into pre-Colonial farming practices in the region. The discovery of this 1,000-year-old farm system serves as a reminder of the rich history and cultural heritage of the Native American communities that once thrived in Michigan’s Upper Peninsula.

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Ancient Civilizations

Uncovering Hidden Secrets: A 3,500-Year-Old Cemetery Reveals New Insights into Bronze Age History

Bronze Age life changed radically around 1500 BC in Central Europe. New research reveals diets narrowed, millet was introduced, migration slowed, and social systems became looser challenging old ideas about nomadic Tumulus culture herders.

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The discovery of a 3,500-year-old cemetery in Hungary has shed new light on a pivotal period in Central European history. A team of international researchers, led by Tamás Hajdu and Claudio Cavazzuti, has conducted a comprehensive bioarchaeological investigation into the Bronze Age cemetery at Tiszafüred-Majoroshalom. The findings have rewritten our understanding of this era, revealing significant changes in people’s lives, diets, social systems, and even burial customs.

The multidisciplinary research was based on the excavation of a Bronze Age cemetery that was used during both the Middle Bronze Age (Füzesabony culture) and the Late Bronze Age (Tumulus culture). By comparing the subsistence strategies before and after this era-changing event, the researchers were able to identify key differences in people’s lifestyles.

The study aimed to answer whether the spread of the Tumulus culture was a result of new groups arriving or if it was simply an evolution of the autochtonous people’s way of life. The team also examined whether changes in settlement patterns around 1500 BC were indicative of a shift towards more mobile and pastoral lifestyles.

The results of this groundbreaking research are nothing short of revolutionary:

* Dietary changes: Nitrogen stable isotope studies revealed that people’s diets became more uniform but poorer during the Late Bronze Age, contradicting previous ideas about the Tumulus culture’s supposed focus on animal husbandry.
* Introduction of broomcorn millet: Carbon isotope analyses indicated that the consumption of this fast-growing and high-energy plant began at the start of the Late Bronze Age, marking the earliest known occurrence in Europe.
* Decreased mobility: Strontium isotope investigations showed that populations from the Middle and Late Bronze Ages had distinct mobility patterns. Fewer immigrants were identified during the Late Bronze Age, with a higher presence of individuals arriving from further geographical regions.

The study’s findings have significant implications for our understanding of this pivotal period in European history. By combining traditional archaeological and anthropological studies with modern bioarchaeological analyses, researchers can now better grasp the complex changes associated with the emergence of the Tumulus culture.

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