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Extreme Survival

Unlocking the Secrets of Bat Immunity: A New Platform for Studying Viral Defense Mechanisms

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results could pave the way for the development of new therapies against viral diseases.

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Researchers have long been fascinated by bats’ ability to host highly pathogenic viruses without showing obvious signs of illness. Now, a team led by Dr. Max Kellner and Prof. Josef Penninger has developed an innovative organoid research platform that allows them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues in bats. The results have been published in Nature Immunology and could pave the way for the development of new therapies against viral diseases.

The researchers used tissue samples from Egyptian fruit bats, which are natural hosts of the highly pathogenic Marburg virus, to generate organoids that mimic the initial viral exposure – mucosal surfaces serve as entry points for many viruses into the body. The team successfully infected both bat and human airway organoids with the Marburg virus in a high-security Biosafety Level 4 (S4) laboratory.

Compared to human models, bat organoids exhibited a significantly higher baseline antiviral immune activity even before infection. This likely enables bats to control viral replication early in infected mucosal tissues, while human cells are less effective at recognizing the Marburg virus in the early stages of infection, allowing uncontrolled replication and spread throughout the body.

The researchers discovered that type III interferons play a crucial role in the mucosal antiviral immunity of Egyptian fruit bats. After infection with various zoonotic viruses, bat organoids exhibited an exceptionally strong production of these interferons. The team confirmed the strong antiviral activity of these interferons through additional stimulation experiments and genetic modifications.

The results suggest that bats can effectively prevent uncontrolled viral replication through a combination of innate immune processes, thereby avoiding viral diseases. Understanding the resilience mechanisms of these animals against highly pathogenic viruses and the evolutionary adaptation of their immune systems is essential for developing antiviral therapies and fighting future pandemics.

In addition to the novel insights into the antiviral mechanisms of bat mucosal tissues, bat organoids will offer an innovative platform for more precise studies of the complex biology of bats at the genetic and molecular levels. The research team plans to further develop the organoid models in terms of complexity and make them available to the scientific community.

Only by working together can we understand the complex mechanisms that evolution has shaped in animals like bats, and from this, develop new approaches for combating and treating viral diseases.

Early Humans

The Hidden Legacy of the Denisovans: Uncovering the Secrets of Human Evolution

Denisovans, a mysterious human relative, left behind far more than a handful of fossils—they left genetic fingerprints in modern humans across the globe. Multiple interbreeding events with distinct Denisovan populations helped shape traits like high-altitude survival in Tibetans, cold-weather adaptation in Inuits, and enhanced immunity. Their influence spanned from Siberia to South America, and scientists are now uncovering how these genetic gifts transformed human evolution, even with such limited physical remains.

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The discovery of the Denisovans has revolutionized our understanding of human evolution. In 2010, scientists uncovered the first draft of the Neanderthal genome, confirming that early humans had interbred with these extinct relatives. Just months later, a finger bone found in Denisova Cave revealed the presence of another unknown hominin group, the Denisovans. Like their Neanderthal counterparts, researchers have found evidence of interbreeding between modern humans and Denisovans.

According to Dr. Linda Ongaro, Postdoctoral Researcher at Trinity College Dublin’s School of Genetics and Microbiology, this phenomenon is not unique to a single event but rather the result of multiple interbreeding episodes that shaped the course of human history. “It’s a common misconception that humans evolved suddenly and neatly from one common ancestor,” she notes. “The more we learn, the more we realize interbreeding with different hominins occurred and helped shape the people we are today.”

Despite the limited Denisovan fossil record, scientists have managed to uncover significant evidence of their genetic legacy. By leveraging surviving segments in modern human genomes, researchers have identified at least three past events where genes from distinct Denisovan populations were incorporated into the genetic signatures of humans.

These events reveal varying degrees of genetic similarity to the Denisovan remains found in the Altai region, suggesting a complex relationship among these closely related groups. In their review, Dr. Ongaro and Professor Emilia Huerta-Sanchez highlight evidence that Denisovans lived across a vast territory stretching from Siberia to Southeast Asia and from Oceania to South America. Different groups appear to have been adapted to their own specific environments.

Moreover, scientists have detailed several Denisovan-derived genes that provided survival advantages in different parts of the world. For example, one genetic locus confers tolerance to hypoxia (low oxygen conditions), which makes sense in Tibetan populations; multiple genes confer heightened immunity; and one gene impacts lipid metabolism, providing heat when stimulated by cold, giving an advantage to Inuit populations in the Arctic.

Dr. Ongaro emphasizes that there are numerous future directions for research that will help tell a more complete story of how the Denisovans impacted modern humans. These include more detailed genetic analyses in understudied populations and integrating more genetic data with archaeological information, which could reveal currently hidden traces of Denisovan ancestry.

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Bacteria

Unlocking the Secrets of Mars: Cosmic Rays Reveal Hidden Potential for Life

Cosmic rays from deep space might be the secret energy source that allows life to exist underground on Mars and icy moons like Enceladus and Europa. New research reveals that when these rays interact with water or ice below the surface, they release energy-carrying electrons that could feed microscopic life, a process known as radiolysis. This breakthrough suggests that life doesn’t need sunlight or heat, just some buried water and radiation.

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As scientists continue to explore the vast expanse of our solar system, a new study has shed light on a long-held assumption about the conditions necessary for life to thrive. Researchers at NYU Abu Dhabi have made a groundbreaking discovery that challenges the traditional view that life can only exist near sunlight or volcanic heat. Their findings suggest that high-energy particles from space, known as cosmic rays, could create the energy needed to support microscopic life underground on planets and moons in our solar system.

The research, led by Principal Investigator Dimitra Atri, focused on what happens when cosmic rays hit water or ice underground. The impact breaks water molecules apart and releases tiny particles called electrons. Some bacteria on Earth can use these electrons for energy, similar to how plants use sunlight. This process is called radiolysis, and it can power life even in dark, cold environments with no sunlight.

Using computer simulations, the researchers studied how much energy this process could produce on Mars and on the icy moons of Jupiter and Saturn. These moons, which are covered in thick layers of ice, are believed to have water hidden below their surfaces. The study found that Saturn’s icy moon Enceladus had the most potential to support life in this way, followed by Mars, and then Jupiter’s moon Europa.

“This discovery changes the way we think about where life might exist,” said Atri. “Instead of looking only for warm planets with sunlight, we can now consider places that are cold and dark, as long as they have some water beneath the surface and are exposed to cosmic rays. Life might be able to survive in more places than we ever imagined.”

The study introduces a new idea called the Radiolytic Habitable Zone. Unlike the traditional “Goldilocks Zone” — the area around a star where a planet could have liquid water on its surface — this new zone focuses on places where water exists underground and can be energized by cosmic radiation. Since cosmic rays are found throughout space, this could mean there are many more places in the universe where life could exist.

The findings provide new guidance for future space missions. Instead of only looking for signs of life on the surface, scientists might also explore underground environments on Mars and the icy moons, using tools that can detect chemical energy created by cosmic radiation.

This research opens up exciting new possibilities in the search for life beyond Earth and suggests that even the darkest, coldest places in the solar system could have the right conditions for life to survive. As we continue to explore the mysteries of our universe, it’s clear that there’s still much to learn, and this discovery is a thrilling reminder of the incredible potential that lies just beneath the surface.

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Agriculture and Food

The Ancient Origins of Potatoes Revealed

About 9 million years ago, a wild interspecies fling between tomato-like plants and potato relatives in South America gave rise to one of the world’s most important crops: the potato. Scientists have now traced its roots to a rare natural hybridization that created the tuber, a storage organ that allowed the plant to survive harsh Andean environments and spread rapidly.

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The mystery of where potatoes came from has been solved by an international research team. Scientists have uncovered that 9 million years ago, a natural interbreeding event occurred between tomato plants and potato-like species from South America, giving rise to the modern-day potato. This ancient evolutionary event triggered the formation of the tuber, the enlarged underground structure that stores nutrients in plants like potatoes, yams, and taros.

The research team analyzed 450 genomes from cultivated potatoes and 56 wild potato species to solve this long-standing mystery. They found that every potato species contained a stable mix of genetic material from both Etuberosum and tomato plants, suggesting an ancient hybridization between the two. The team also traced the origins of the potato’s key tuber-forming genes, which are a combination of genetic material from each parent.

The discovery reveals how a hybridization event can spark the evolution of new traits, allowing even more species to emerge. This is particularly significant in the context of one of the world’s most important crops, the potato. As one of the world’s most widely cultivated foods, potatoes have long puzzled scientists with their seemingly identical appearance to Etuberosum plants but lack of tubers.

To fill this knowledge gap, researchers analyzed 450 genomes from cultivated potatoes and 56 wild potato species. They found that every potato species contained a stable mix of genetic material from both Etuberosum and tomato plants. This suggests an ancient hybridization event occurred between the two, which gave rise to the modern-day potato.

The team’s findings also reveal how this ancient evolutionary innovation coincided with the rapid uplift of the Andes mountains. As new ecological environments emerged, early potatoes were able to quickly adapt and survive in harsh weather conditions using their tubers as a nutrient storage system. This allowed them to rapidly expand and fill diverse ecological niches from mild grasslands to high and cold alpine meadows in Central and South America.

The discovery of the potato’s ancient origins is a significant breakthrough in understanding how new species emerge. It highlights the importance of natural interbreeding events in shaping the evolution of plants and their adaptation to changing environments.

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