Connect with us
We’re experimenting with AI-generated content to help deliver information faster and more efficiently.
While we try to keep things accurate, this content is part of an ongoing experiment and may not always be reliable.
Please double-check important details — we’re not responsible for how the information is used.

Biochemistry Research

Unlocking the Secrets of Brown Algae: A Breakthrough in Biotech Applications

Every year, thousands of tons of brown algae are extracted from the seabed to obtain compounds such as alginates, a polymer composed of sugars that has high density and strength, offering potential biotechnological applications. An international team has deciphered the mechanism by which a type of enzyme, called alginate lyase (AL), is capable of degrading these marine biomaterials, allowing them to be used as carriers of drugs, additives or thickeners, among others. These results will help in the development and design of new ‘tailored alginates’ for specific applications, especially in the food and biomedical industries.

Avatar photo

Published

on

The world of marine biomaterials has long been a treasure trove for scientists seeking innovative solutions. Every year, thousands of tonnes of brown algae are harvested from the seabed, yielding valuable compounds such as alginates, which have potential biotechnological applications. A recent study led by the University of Barcelona has made a groundbreaking discovery in deciphering the mechanism behind alginate lyase (AL), an enzyme capable of degrading these marine biomaterials.

The research team, comprising José Pablo Rivas-Fernández and Carme Rovira from the UB’s Faculty of Chemistry and the UB Institute of Theoretical and Computational Chemistry (IQTCUB), in coordination with Casper Wilkens from the Technical University of Denmark, has published their findings in Nature Communications. This study will significantly contribute to the development and design of new “tailored alginates” for specific applications, particularly in the food and biomedical industries.

Despite the abundance of alginates in the marine environment, their range of opportunities is limited by their inhomogeneous composition. The knowledge of the mechanism of action of AL enzymes when they break down the bonds connecting mannuronic acid-type sugars will help overcome these limitations. “The results lay the groundwork for manipulating these enzymes and designing variants with better catalytic properties and higher efficiency on a large scale,” the researchers explain.

Using industrial techniques and bioprocesses, it will be possible to optimize the production of ‘tailored alginates’ in sufficient quantities to meet society’s needs. This breakthrough also allows for a “better use of natural resources and boost the green economy by using enzymes as key tools in the production of these alginates,” say the authors.

The study was based on computational analysis with the MareNostrum 5 supercomputer, which reconciled previous scientific discrepancies about the number of stages in which the reaction occurs. The simulations have confirmed that the degradation of alginates happens in a single stage and that the polymer breaks at the centre, not at one end. They have also cleared the nature of the transition state as a highly negatively charged species.

This finding suggests that we may be able to control at what point the polymer breaks down by mutations of certain amino acids in the enzyme’s active centre. The enzymes analysed belong to family 7 of lyases, which is the most abundant known to date, allowing extrapolation of the mechanism described to other enzymes with high biotechnological potential.

The results improve understanding of the chemical evolution of alginate during its degradation, a fundamental element for the design of probes capable of identifying and isolating alginate lyases. In this sense, UB researchers are currently working on the design of probes that allow efficient identification of new enzymes active in carbohydrates.

This study is part of Carbocentre, a project funded by a Synergy Grant from the European Research Council (ERC), aiming to advance our understanding of the biotechnological potential of marine biomaterials.

Biochemistry Research

The Double Edge of Love and War: How Female Earwigs Evolved Deadly Claws for Mate Competition

Female earwigs may be evolving exaggerated weaponry just like males. A study from Toho University found that female forceps, once assumed to be passive tools, show the same kind of outsized growth linked to sexual selection as the male’s iconic pincers. This means that female earwigs might be fighting for mates too specifically for access to non-aggressive males challenging long-standing assumptions in evolutionary biology.

Avatar photo

Published

on

The article you provided has been rewritten to improve clarity, structure, and style while maintaining its core ideas. Here is the rewritten content:

In a groundbreaking study published in the Biological Journal of the Linnean Society on June 12, 2025, researchers from Toho University have shed new light on the evolution of deadly claws in female earwigs. For decades, it was believed that these pincer-like appendages were exclusive to males and evolved solely as weapons in battles with rivals. However, the findings of Tomoki Matsuzawa (then an undergraduate) and Associate Professor Junji Konuma have challenged this notion, revealing a surprising parallel between male and female earwigs.

The researchers conducted a quantitative study on the maritime earwig Anisolabis maritima, analyzing the morphometric data of both sexes. They found that not only do females possess forceps, but they also exhibit positive allometry – a phenomenon where certain body parts grow disproportionately large relative to body size. This is strikingly similar to the pattern observed in males, suggesting that female earwigs may have evolved these traits through sexual selection.

In their study, the team measured various dimensions of the head, thorax, abdomen, and bilateral forceps, as well as shape differences between sexes. They discovered that males possess thick, short, and curved forceps, while females have thin, long, and straight ones – a clear example of sexual dimorphism. When they plotted body size against forceps width and length on a log-log scale, the results revealed positive allometry in both males (in forceps width) and females (in forceps length).

Associate Professor Konuma explained that this finding suggests female earwigs may have evolved their forceps as effective weapons in competing for mates. A previous behavioral study had shown that female earwigs engage in competition with each other for small, non-aggressive males. This new research highlights the importance of considering female traits when studying the evolution of insect morphologies.

These groundbreaking findings demonstrate how the complex and fascinating world of insects can continue to surprise us, revealing the intricacies of natural selection and mate competition.

Continue Reading

Biochemistry Research

Unlocking Nature’s Secrets: Scientists Discover Natural Cancer-Fighting Sugar in Sea Cucumbers

Sea cucumbers, long known for cleaning the ocean floor, may also harbor a powerful cancer-fighting secret. Scientists discovered a unique sugar in these marine creatures that can block Sulf-2, an enzyme that cancer cells use to spread. Unlike traditional medications, this compound doesn t cause dangerous blood clotting issues and offers a cleaner, potentially more sustainable way to develop carbohydrate-based drugs if scientists can find a way to synthesize it in the lab.

Avatar photo

Published

on

Unlocking Nature’s Secrets: Scientists Discover Natural Cancer-Fighting Sugar in Sea Cucumbers

In a groundbreaking study, researchers from the University of Mississippi and Georgetown University have discovered a natural sugar compound found in sea cucumbers that can effectively block Sulf-2, an enzyme crucial for cancer growth. This breakthrough has significant implications for the development of new cancer therapies.

The research team, led by Marwa Farrag, a fourth-year doctoral candidate in the UM Department of BioMolecular Sciences, worked tirelessly to isolate and study the sugar compound, fucosylated chondroitin sulfate, from the sea cucumber Holothuria floridana. This unique sugar is not commonly found in other organisms, making it an exciting area of research.

Human cells are covered in tiny, hairlike structures called glycans that help with cell communication, immune responses, and the recognition of threats such as pathogens. Cancer cells alter the expression of certain enzymes, including Sulf-2, which modifies the structure of glycans, helping cancer spread. By inhibiting this enzyme, researchers believe they can effectively fight against the spread of cancer.

Using both computer modeling and laboratory testing, the research team found that the sugar compound from sea cucumbers can effectively inhibit Sulf-2, a promising step towards developing new cancer therapies. This natural source is particularly appealing as it does not carry the risk of transferring viruses and other harmful agents, unlike extracting carbohydrate-based drugs from pigs or other land mammals.

While this discovery holds great promise, the researchers acknowledge that further study is needed to develop a viable treatment. One of the challenges lies in finding a way to synthesize the sugar compound for future testing. The interdisciplinary nature of the scientific study highlights the importance of cross-disciplinary collaboration in tackling complex diseases like cancer.

This groundbreaking research has far-reaching implications for the medical field and demonstrates the power of scientific discovery in unlocking nature’s secrets. As researchers continue to explore this area, they may uncover new therapies that can effectively combat cancer, ultimately saving lives and improving patient outcomes.

Continue Reading

Air Quality

Unlocking the Secrets of Environmental DNA: A Powerful Tool for Wildlife and Human Surveillance

Environmental DNA from the air, captured with simple air filters, can track everything from illegal drugs to the wildlife it was originally designed to study.

Avatar photo

Published

on

Dublin, a city known for its warm welcome and lively traditional music, has an unsuspecting secret – the air is teeming with DNA from various species. From cannabis to bobcats, even magic mushrooms – at least their DNA – are floating on the breeze. A new study reveals that this phenomenon can be leveraged to track wildlife, viruses, and other substances in unprecedented ways.

David Duffy, Ph.D., a professor of wildlife disease genomics at the University of Florida, has developed innovative methods for deciphering environmental DNA (eDNA). His lab has been studying sea turtle genetics using eDNA from water samples. Expanding on this research, they’ve created tools to study every species – including humans – from DNA captured in environmental samples like air filters.

“What we’re finding is that you can get intact large fragments of DNA from the air,” Duffy said. “That means you can study species without directly having to disturb them.” This approach opens up vast possibilities for tracking all species in an area simultaneously, from microbes and viruses to vertebrates like bobcats and humans.

A proof-of-concept experiment demonstrated that researchers could pick up signs of hundreds of different human pathogens from the Dublin air, including viruses and bacteria. This surveillance method can aid scientists in tracking emerging diseases. Additionally, it can track common allergens, such as peanut or pollen, more precisely than current methods allow.

In another test, Duffy’s lab identified the origin of bobcats and spiders whose DNA was collected from air filters in a Florida forest. This technique allows researchers to track endangered species without having to lay eyes on them or gather scat samples – all while knowing their exact origin is crucial for conservation efforts.

This powerful analysis is paired with impressive speed and efficiency, as demonstrated by the team’s ability to process DNA for every species in as little as a day using compact, affordable equipment, and software hosted in the cloud. This quick turnaround is orders of magnitude faster than was possible just a few years ago, making advanced environmental studies more accessible to scientists worldwide.

However, Duffy and his collaborators have called for ethical guardrails due to the potential for sensitive human genetic data to be identified using these tools.

“It seems like science fiction, but it’s becoming science fact,” Duffy said. “The technology is finally matching the scale of environmental problems.” As researchers continue to explore the capabilities of eDNA, they must also address the challenges and implications of this rapidly developing field.

Continue Reading

Trending