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Chronic Illness

Unlocking Liver Energy Storage: Scientists Discover Key Gene Role in Metabolic Disease Risk

A new study reveals that a single gene plays a big role in how the liver stores energy, a process that’s critical for overall health and for managing diseases like type 2 diabetes. The research focuses on the PPP1R3B gene. This gene tells the liver how to handle energy: store it as glycogen (a form of sugar) or triglycerides (a type of fat).

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The discovery of a single gene’s significant impact on how the liver stores energy has shed light on its crucial role in managing diseases like type 2 diabetes. Led by Kate Townsend Creasy, PhD, Assistant Professor of Nutrition Science at Penn Nursing, the research focuses on the PPP1R3B gene, which dictates the liver’s handling of energy storage as either glycogen (a form of sugar) or triglycerides (a type of fat).

When the PPP1R3B gene is more active, the liver tends to store more energy as glycogen. Conversely, when it is less active, the liver stores more energy as fat. This shift between glycogen and fat storage affects blood sugar and fat levels in the body.

Large-scale genomics studies have reported associations between mutations in the PPP1R3B gene and several metabolic conditions, including type 2 diabetes and fatty liver disease. However, it was unclear how the gene played a role in these conditions.

“Our research shows that PPP1R3B is like a control switch in the liver,” said Creasy. “It directs whether the liver stores energy for quick use in the form of glycogen or for longer-term storage as fat.”

The team observed changes in how efficiently mice and cells with genetic manipulations of PPP1R3B could use either glucose or fat for energy. This discovery has significant implications for finding new ways to help people with metabolic diseases using precision nutrition approaches based on their genetics.

Co-authors from the Perelman School of Medicine include a diverse group of experts in various fields, and the National Institutes of Health supported this research.

Chronic Illness

The Hidden Link Between Sleep Schedule and Disease Risk

A global study of over 88,000 adults reveals that poor sleep habits—like going to bed inconsistently or having disrupted circadian rhythms—are tied to dramatically higher risks for dozens of diseases, including liver cirrhosis and gangrene. Contrary to common belief, sleeping more than 9 hours wasn’t found to be harmful when measured objectively, exposing flaws in previous research. Scientists now say it’s time to redefine “good sleep” to include regularity, not just duration, as biological mechanisms like inflammation may underlie these powerful sleep-disease links.

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The recent publication of a groundbreaking international study has shed new light on the often-overlooked connection between our sleep schedules and the risk of various diseases. The research, led by teams from Peking University and Army Medical University, analyzed objective sleep data from an impressive 88,461 adults in the UK Biobank, revealing significant associations between sleep traits and a staggering 172 diseases.

One of the key findings is that poor sleep regularity – including inconsistent bedtimes and irregular circadian rhythms – is a critical factor in disease risk. The study used actigraphy data to monitor participants’ sleep patterns over an average of 6.8 years, identifying that 92 diseases had more than 20% of their risk attributed to subpar sleep behavior.

Perhaps most concerning are the links between certain sleep habits and specific diseases. For instance, going to bed after 00:30 was found to increase the risk of liver cirrhosis by an alarming 2.57 times, while low interdaily stability (a measure of consistency in daily sleep patterns) raised the risk of gangrene by a staggering 2.61 times.

Interestingly, the study also challenged previous claims that “long sleep” (more than 9 hours) is inherently bad for our health. While subjective reports have suggested links between long sleep and stroke or heart disease, the objective data revealed only one such association – in this case, with an increased risk of certain diseases.

It’s possible that misclassification may be to blame for these previous findings: a shocking 21.67% of participants who reported sleeping more than 9 hours actually slept less than 6 hours, highlighting how often actual sleep time is confused with time spent in bed.

The lead author of the study, Prof. Shengfeng Wang, emphasized that the results underscore the importance of considering sleep regularity beyond just duration. As we strive to maintain good health, it’s essential to prioritize a consistent and predictable sleep schedule – a crucial factor often overlooked until now.

Future research will delve deeper into the causality of these associations and explore the impact of sleep interventions on chronic disease outcomes. By shedding more light on this critical aspect of our overall well-being, we can work towards developing targeted strategies for promoting healthy sleep habits and reducing disease risk.

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Alzheimer's Research

Walking 7000 Steps a Day Can Be Just as Beneficial as 10,000 – Here’s Why

Walking 7000 steps a day may be just as powerful as hitting the much-hyped 10,000-step goal when it comes to reducing the risk of early death and disease. A sweeping global review of 57 studies shows that 7000 steps per day slashes the risk of dying early by nearly half—and brings major benefits across heart health, dementia, depression, and more. The bonus? Even walking from 2000 to 4000 steps per day brings measurable improvements. For millions of people, this study redefines what it means to “move enough.”

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The study, led by Professor Melody Ding from the University of Sydney, has made a groundbreaking discovery that walking 7000 steps a day can offer similar health benefits as walking 10,000 steps. This finding is based on an analysis of data from 57 studies conducted in over ten countries between 2014 and 2025.

The researchers examined the impact of different daily step counts on various health outcomes, including cardiovascular disease and cancer. They found that walking at least 7000 steps a day can significantly improve eight major health outcomes, such as reducing the risk of cardiovascular disease, dementia, and depressive symptoms.

Professor Melody Ding emphasized that aiming for 7000 steps is a realistic goal for people who struggle to meet traditional exercise guidelines. “Even small increases in step counts, like going from 2000 to 4000 steps a day, are associated with significant health gains,” she said.

The researchers compared the health outcomes of people walking at different step increments, starting at 2000 steps per day. They found that:

* When compared to 2000 steps a day, walking 7000 steps a day was associated with a 47% lower risk of death from cardiovascular disease and cancer.
* For those who cannot yet achieve 7000 steps a day, even small increases in step counts can lead to significant health improvements.

Experts are calling for future studies to explore how step goals should vary based on age, health status, and region. They also suggest including diverse populations and longer-term data to strengthen the evidence. Professor Ding emphasizes that this kind of detail is rare and will be useful for health practitioners when tailoring advice for patients.

Overall, the study suggests that walking 7000 steps a day can be a more achievable and beneficial goal than previously thought, and even small increases in daily movement can lead to meaningful health improvements.

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Alternative Medicine

“The Power of Movement: How Regular Exercise Can Add Years to Your Life”

Adopting a physically active lifestyle at any stage of adulthood significantly lowers your risk of dying from any cause, especially from cardiovascular disease. A sweeping analysis of 85 studies confirms that those who stay active consistently reduce their mortality risk by 30–40%, while even those who become active later in life enjoy a 20–25% reduction.

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The British Journal of Sports Medicine has published a study that finds being consistently physically active in adulthood is linked to a 30-40% lower risk of death from any cause in later life. This means that even if you haven’t been active throughout your life, it’s never too late to start moving more and reap the benefits. In fact, switching to a more active lifestyle at any point in adult life may extend your lifespan.

The study analyzed data from 85 studies that measured physical activity at two or more points in time. The results showed that consistently active people had around a 30-40% lower risk of dying from any cause, while those who increased their levels of physical activity from below the recommended levels had a 20-25% lower risk of death from any cause.

The researchers also found that generally, the associations observed between a high level of physical activity and a lower risk of death were more evident for cardiovascular disease than for cancer. However, the evidence for the associations between physical activity patterns and death from a specific cause remained inconclusive, especially for death from cancer.

Despite these limitations, the study’s findings have important public health implications. The researchers emphasize the importance of sustained physical activity over time and suggest that future interventions may not only target inactive people but also support active people to maintain their activity.

In conclusion, this study highlights the power of movement in adding years to your life. Whether you’re 20 or 60, it’s never too late to start exercising regularly and reap the benefits for your overall health and well-being. So, get moving and make physical activity a priority in your life!

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