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Animals

A “Roadmap” to Understanding the Fruit Fly Brain: Breakthrough Study Reveals Comprehensive Insights into Entire Nervous System

Researchers have gained comprehensive insights into the entire nervous system of the fruit fly (Drosophila melanogaster). The study describes in detail the neurons that span the entire nervous system of the adult fruit fly. The researchers also compared the complete set of neural connections (the connectome) in a female and a male specimen — and identified differences.

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The fruit fly (Drosophila melanogaster) has long been a model organism for scientists studying genetics, development, and behavior. However, despite its importance, the intricacies of the fruit fly’s nervous system have remained somewhat of a mystery – until now. Researchers at Leipzig University and other institutions have made a groundbreaking discovery, publishing a study in Nature that provides comprehensive insights into the entire nervous system of the adult fruit fly.

For the first time, scientists have mapped out the neural connections (the connectome) in a female and a male specimen, revealing differences between the two sexes. This breakthrough is a significant step forward in understanding the complex interactions within the fruit fly’s brain and nervous system.

The study, led by Dr. Katharina Eichler from Leipzig University, involved analyzing three connectomes: one female brain data set and two nerve cord data sets (one male, one female). The researchers used light microscopy to identify all neurons in the neck of the fruit fly that could be visualized using this technique.

This allowed them to analyze the circuits formed by these cells in their entirety. When comparing male and female neurons, the scientists identified sex-specific differences for the first time. They found previously unknown cells that exist only in one sex and are absent in the other.

One notable example is a descending neuron known as aSP22, which communicates with neurons present only in females. This finding provides an explanation for the behavioral differences observed when this neuron is active: female flies extend their abdomen to lay eggs, while males curl theirs forward to mate.

The study’s findings are significant not only because they provide a comprehensive overview of the fruit fly connectome but also because they offer a “roadmap” for future research. By understanding the intricate connections within the nervous system, scientists can design more intelligent experiments to investigate the function of individual neurons or entire circuits – saving time and resources.

As Eichler notes, now that the technical challenges in analyzing the fruit fly’s nervous system have been overcome, her research group is working on two new data sets covering the entire central nervous system of both a female and a male specimen. This continued research will undoubtedly shed more light on the complexities of the fruit fly brain and its implications for our understanding of nervous systems in general.

Agriculture and Food

The Sleeping Side Preference of Cats: A Survival Strategy?

Cats overwhelmingly choose to sleep on their left side, a habit researchers say could be tied to survival. This sleep position activates the brain’s right hemisphere upon waking, perfect for detecting danger and reacting swiftly. Left-side snoozing may be more than a preference; it might be evolution’s secret trick.

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The world of cats is fascinating, especially when it comes to their sleeping habits. Researchers from Italy, Germany, Canada, Switzerland, and Turkey have made an intriguing discovery – cats prefer to sleep on their left side. This bias towards one side might seem trivial at first, but the team behind this study believes it holds a significant evolutionary advantage.

Cats are notorious for spending around 12 to 16 hours a day snoozing. They often find elevated places to rest, making it difficult for predators to access them from below. The research team, led by Dr. Sevim Isparta and Professor Onur Güntürkün, aimed to understand the behavior behind this preference. They analyzed over 400 YouTube videos featuring cats sleeping on one side or the other.

The results showed that two-thirds of these videos had cats sleeping on their left side. So, what’s the explanation? According to the researchers, when a cat sleeps on its left side and wakes up, it perceives its surroundings with its left visual field. This visual information is processed in the right hemisphere of the brain, which specializes in spatial awareness and threat processing.

This might seem like an insignificant detail, but for cats, it’s a crucial aspect of survival. By sleeping on their left side, they can quickly respond to potential threats or prey upon waking up. The researchers conclude that this preference could be a key survival strategy for cats.

The study published in the journal Current Biology provides valuable insights into the fascinating world of cat behavior and evolution. As we continue to learn more about our feline friends, we might just uncover even more surprising advantages behind their seemingly ordinary habits.

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Animals

“New Bat-Borne Viruses Discovered in China Pose Potential Pandemic Threat”

Two newly discovered viruses lurking in bats are dangerously similar to Nipah and Hendra, both of which have caused deadly outbreaks in humans. Found in fruit bats near villages, these viruses may spread through urine-contaminated fruit, raising serious concerns. And that’s just the start—scientists found 20 other unknown viruses hiding in bat kidneys.

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Scientists in China have made a groundbreaking discovery that could potentially alter our understanding of pandemics. Researchers from the Yunnan Institute of Endemic Disease Control and Prevention have found two new viruses in bats that are closely related to the deadly Nipah and Hendra viruses, which can cause severe brain inflammation and respiratory disease in humans.

The study, published in the open-access journal PLOS Pathogens, analyzed 142 bat kidneys from ten species collected over four years across five areas of Yunnan province. Using advanced genetic sequencing, the team identified 22 viruses – 20 of them never seen before. Two of these newly discovered viruses belong to the henipavirus genus, which includes Nipah and Hendra viruses known for their high fatality rates in humans.

The researchers’ findings are concerning because these henipaviruses can spread through urine, raising the risk of contaminated fruit and the possibility of the viruses jumping to humans or livestock. This highlights the importance of comprehensive microbial analyses of previously understudied organs like bat kidneys to better assess spillover risks from bat populations.

As bats are natural reservoirs for a wide range of microorganisms, including many notable pathogens that have been transmitted to humans, it is essential to conduct thorough research on these animals’ infectomes. This study not only broadens our understanding of the bat kidney infectome but also underscores critical zoonotic threats and highlights the need for comprehensive microbial analyses.

The authors emphasize that their findings raise urgent concerns about the potential for these viruses to spill over into humans or livestock, making it crucial for scientists, policymakers, and public health officials to work together to mitigate this risk. By analyzing the infectome of bat kidneys collected near village orchards and caves in Yunnan, the researchers have uncovered not only the diverse microbes bats carry but also the first full-length genomes of novel bat-borne henipaviruses closely related to Hendra and Nipah viruses identified in China.

Funding for this study came from various grants and programs, including the National Key R&D Program of China, Yunnan Revitalization Talent Support Program Top Physician Project, National Natural Science Foundation of China, and others. The funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript.

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Animals

The Tumat Puppies: Unveiling the Ancient Secrets of Wolf Evolution

Two Ice Age wolf pups once thought to be early dogs have been identified as wild wolves, thanks to detailed DNA and chemical analysis. Surprisingly, their last meals included woolly rhinoceros meat—an unusually large prey item—hinting that ancient wolves might have been bigger than today’s. Their well-preserved bodies also shed light on wolf pack behavior and Ice Age environments.

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The Tumat Puppies, two remarkably well-preserved puppy remains found in northern Siberia, have shed new light on the evolution of wolves. The genetic analysis of their remains has revealed that they are most likely wolves, and not related to domestic dogs as previously suggested.

The puppies were discovered in layers of soil, preserved in ice, alongside the bones of woolly mammoths, some of which showed signs of having been burned and processed by humans. This led scientists to wonder if the site was once used by humans to butcher mammoths, and whether the puppies might have had a connection to people, possibly as early dogs or tamed wolves that hung around humans for food.

However, a new study has shown that based on genetic data from the animals’ gut contents and other chemical ‘fingerprints’ found in their bones, teeth, and tissue, that the way they were living, what they were eating, and the environment they existed in, points to the puppies being wolf cubs and not early domesticated dogs.

The research findings suggest that these Pleistocene wolves may have been somewhat bigger than the wolves of today. The “Tumat Puppies” challenge the original hypothesis that they belonged to a dog population that eventually died out and didn’t lead to today’s domestic dogs.

Anne Kathrine Runge, from the University of York’s Department of Archaeology, said: “It was incredible to find two sisters from this era so well preserved, but even more incredible that we can now tell so much of their story, down to the last meal that they ate.”

The research has also provided insights into the environment and ecosystems of the time. The cubs’ stomachs contained tiny fossilized plant remains, indicating a diverse landscape with varied habitats, including prairie grasses, leaves from the shrub genus Dryas, and willow twigs.

Dr Nathan Wales, from the University of York’s Department of Archaeology, said: “We know grey wolves have been around as a species for hundreds of thousands of years based on skeletal remains from palaeontological sites. The soft tissues preserved in the Tumat Puppies gives us access to other ways of investigating wolves and their evolutionary line.”

The research findings, however, means that the hunt for the oldest dog — and their place of origin — is still on.

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