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Asthma

Fatty Liver in Pregnancy Increases Risk of Preterm Birth, Study Finds

Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study.

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Pregnant women who suffer from metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, are more likely to give birth prematurely. A new study published in the journal eClinicalMedicine has found that these women have a significantly higher risk of preterm birth, and this increased risk cannot be attributed solely to their weight or obesity.

According to the research conducted by Karolinska Institutet, one in five people in Sweden may have MASLD, while globally, it could affect as many as three out of ten individuals. Common risk factors for developing the disease include metabolic disorders like type 2 diabetes and being overweight or obese. The study’s findings are based on Swedish registry data and included a total of 240 births among women with MASLD, along with 1140 matched births from the general population.

Alarmingly, the research revealed that women with MASLD were more than three times as likely to give birth prematurely compared to those without the disease. This increased risk persisted even after adjusting for factors such as weight and metabolic disorders. The study’s lead author suggests that this association may not solely be due to a high BMI, implying that the liver disease itself could have negative effects on pregnancy outcomes.

Moreover, women with MASLD had a 63 percent higher risk of caesarean section compared to the control group. However, this increased risk seemed to be explained by their high BMI, as no significant difference was observed when comparing them to overweight or obese women without fatty liver disease.

While the study’s findings are concerning, it is essential to note that MASLD itself did not increase the risk of congenital malformations in the children born to these women. The authors acknowledge that their research may have been influenced by other factors and emphasize the importance of closely monitoring pregnant women with MASLD to reduce the risk of complications.

The study’s conclusions highlight the need for specific recommendations regarding pregnancy care for women with MASLD, which could potentially be added to clinical guidelines for managing the disease.

Animal Learning and Intelligence

“Breathe with Identity: The Surprising Link Between Your Breath and You”

Scientists have discovered that your breathing pattern is as unique as a fingerprint and it may reveal more than just your identity. Using a 24-hour wearable device, researchers achieved nearly 97% accuracy in identifying people based solely on how they breathe through their nose. Even more intriguingly, these respiratory signatures correlated with traits like anxiety levels, sleep cycles, and body mass index. The findings suggest that breathing isn t just a passive process it might actively shape our mental and emotional well-being, opening up the possibility of using breath training for diagnosis and treatment.

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Now, let me rewrite the article to make it more accessible and engaging for a general audience:

Breathe with Identity: The Surprising Link Between Your Breath and You

Imagine if your breath could reveal not only your health but also your identity. Sounds like science fiction? Think again! A recent study published in the journal Current Biology has shown that scientists can identify individuals based solely on their breathing patterns with an astonishing 96.8% accuracy.

The research was led by Noam Sobel and Timna Soroka from the Weizmann Institute of Science, Israel. They were intrigued by the connection between our brain and breathing, which is processed during inhalation in mammals. Since every brain is unique, wouldn’t each person’s breathing pattern reflect that?

To test this idea, the team developed a lightweight wearable device that tracks nasal airflow continuously for 24 hours using soft tubes placed under the nostrils. This innovative approach revealed that people’s respiratory patterns are as distinctive as fingerprints – and just as reliable.

In an experiment with 100 healthy young adults, the researchers asked them to go about their daily lives while wearing the device. The collected data allowed them to identify individuals with high accuracy, rivaling the precision of some voice recognition technologies. What’s more, the study found that these respiratory “fingerprints” correlated with various aspects of a person’s life, such as:

* Body mass index (BMI)
* Sleep-wake cycle
* Levels of depression and anxiety
* Behavioral traits

For instance, participants who scored relatively higher on anxiety questionnaires had shorter inhales and more variability in the pauses between breaths during sleep. This suggests that long-term nasal airflow monitoring may serve as a window into physical and emotional well-being.

But here’s the really interesting part: what if the way we breathe affects our mental and emotional states? Could changing our breathing patterns actually change those conditions? The researchers are already investigating this possibility, aiming to develop a more discreet and comfortable version of the device for everyday use.

Sobel notes, “We intuitively assume that how depressed or anxious you are changes the way you breathe. But it might be the other way around. Perhaps the way you breathe makes you anxious or depressed. If that’s true, we might be able to change the way you breathe to change those conditions.”

This study opens up exciting possibilities for using respiratory monitoring as a tool for improving mental and emotional well-being. And who knows? Maybe one day, your breath will be the key to unlocking a healthier, happier you!

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Asthma

Controlling Key Health Risk Factors Can Significantly Reduce Early Death Risk for Those with High Blood Pressure

Controlling blood pressure is not the only way to treat hypertension. A new study identified eight associated risk factors. Each risk factor addressed was associated with a 13% lower risk of premature death. Patients who addressed at least four of these risk factors had no greater risk of an early death than those without high blood pressure.

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The study, led by researchers at Tulane University, has made a groundbreaking discovery. By controlling several key health risk factors, people with high blood pressure can significantly reduce – and possibly eliminate – their increased risk of premature death.

The research team tracked over 70,000 people with hypertension and more than 224,000 without it using data from the UK Biobank. They followed participants for nearly 14 years to understand how managing these risk factors affected early mortality – defined as dying before age 80.

The eight health risk factors evaluated in the study include:

1. Blood pressure
2. Body mass index (BMI)
3. Waist circumference
4. LDL “bad” cholesterol
5. Blood sugar
6. Kidney function
7. Smoking status
8. Physical activity

Researchers found that hypertensive patients who had addressed at least four of these risk factors had no greater risk of an early death than those without high blood pressure.

“Our study shows that controlling blood pressure is not the only way to treat hypertensive patients, because high blood pressure can affect these other factors,” said Dr. Lu Qi, corresponding author and professor of epidemiology at Tulane University. “By addressing the individual risk factors, we can help prevent early death for those with hypertension.”

Hypertension, defined as a blood pressure of 130 mmHg or higher, is the leading preventable risk factor for premature death worldwide.

The study’s findings are significant:

* Addressing each additional risk factor was associated with a 13% lower risk of early death
* Optimal risk control (having 7 or more of the risk factors addressed) was linked to 40% less risk of early death, 39% less risk of early death due to cancer, and 53% less risk of death due to cardiovascular disease

Only 7% of hypertensive participants in the study had seven or more risk factors under control, highlighting a major opportunity for prevention. Researchers say the findings underscore the importance of personalized, multifaceted care – not just prescribing medication for blood pressure, but addressing a broader range of health behaviors and conditions.

“This is the first study to explore the association between controlling joint risk factors and premature mortality in patients with hypertension,” Qi said. “Importantly, we found that any hypertension-related excess risk of an early death could be entirely eliminated by addressing these risk factors.”

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Air Pollution

One in Ten Asthma Cases Can Be Avoided with a Better Urban Environment

The combination of air pollution, dense urban development and limited green spaces increases the risk of asthma in both children and adults.

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The urban environment plays a significant role in the development of asthma, particularly in densely populated areas with limited green spaces. A recent study conducted by researchers from Karolinska Institutet has shed light on this issue, highlighting that nearly one in ten asthma cases can be avoided with a better urban environment.

The study, which involved over 350,000 people from seven European countries, analyzed the impact of air pollution, outdoor temperatures, and urban density on the risk of developing asthma. The researchers used satellite images to assess the environmental exposures, categorizing areas as grey (buildings), green (green spaces), or blue (water).

According to the study, nearly 7,500 participants developed asthma during the study period. The researchers found that 11.6% of these cases could be attributed to the combination of environmental factors, such as air pollution and lack of green spaces.

“This is a significant finding,” says Zhebin Yu, first author of the study. “Our research shows that by improving the urban environment, we can reduce the risk of asthma in children and adults.”

The study’s findings have important implications for urban planning and policy-making. By identifying areas with high environmental risks, policymakers can take steps to mitigate these risks and create healthier environments.

“The method used in this study can be applied to existing urban areas as well as new developments,” says Erik Melén, professor at the Department of Clinical Research and Education, Södersjukhuset, and last author of the study. “This will enable us to better understand how environmental factors contribute to disease development and inform strategies for prevention.”

The researchers plan to conduct further studies, including an examination of blood samples from some participants to identify their metabolome – a composite picture of the body’s metabolism and breakdown products.

This research has significant implications for our understanding of asthma development and may lead to new strategies for preventing this condition. By improving the urban environment, we can reduce the risk of asthma and create healthier communities.

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