The air we breathe has long been a concern for public health, but a recent study by Emory University researchers sheds light on a specific and alarming link between air pollution and pregnancy risks. Published in Environmental Science & Technology, the research reveals that exposure to tiny particles in air pollution during pregnancy can disrupt maternal metabolism, leading to increased risk of various negative birth outcomes.

The study analyzed blood samples from 330 pregnant women in the Atlanta metropolitan area, providing a detailed insight into how ambient fine particulate matter (PM2.5) affects the metabolism of pregnant women and contributes to increased risks of preterm and early term births. This pioneering work marks the first time researchers have been able to investigate the specific fine particles responsible for these adverse outcomes.

“The link between air pollution and premature birth has been well established, but for the first time we were able to look at the detailed pathway and specific fine particles to identify how they are reflected in the increased risk of adverse birth outcomes,” says Donghai Liang, PhD, study lead author and associate professor of environmental health. “This is important because if we can figure out the ‘why’ and ‘how,’ then we can know better how to address it.”

Previous research has shown that pregnant women and fetuses are more vulnerable than other populations to exposure to PM2.5, which is emitted from combustion sources such as vehicle exhaust, industrial processes, and wildfires. This increased vulnerability is linked to a higher likelihood of preterm births, the leading cause of death globally among children under the age of five.

Preterm birth is associated with complications such as cerebral palsy, respiratory distress syndrome, and long-term noncommunicable disease risks. Early term births (37-39 weeks of gestation) are also linked to increased neonatal morbidity and developmental challenges. Approximately 10% of preterm births worldwide are attributable to PM2.5 exposure.

As an air pollution scientist, Liang emphasizes the importance of addressing this issue beyond simply asking people to move away from highly polluted areas. “From a clinical intervention standpoint, it’s critical to gain a better understanding on these pathways and molecules affected by pollution,” he says. “In the future, we may be able to target some of these molecules to develop effective strategies or clinical interventions that could help reduce these adverse health effects.”

This groundbreaking study highlights the urgent need for policymakers and healthcare providers to take action against air pollution, particularly in areas with high levels of PM2.5 exposure. By understanding the molecular link between air pollution and pregnancy risks, we can work towards developing targeted solutions to mitigate these negative outcomes and protect the health of future generations.

Rewritten Article:

In a breakthrough that’s straight out of science fiction, a team of engineers at Caltech has developed a real-life Transformer that can morph in mid-air, allowing it to smoothly transition from flying to rolling on the ground. This innovative technology has far-reaching implications for commercial delivery systems and robotic explorers, making it an exciting development in the field of robotics.

The new robot, dubbed ATMO (aerially transforming morphobot), uses four thrusters to fly but can transform into a ground-rolling configuration using a single motor that lifts its thrusters up or down. This unique design allows ATMO to change its shape and function seamlessly, enabling it to adapt to various environments and situations.

According to Ioannis Mandralis, the lead author of the research paper published in Communications Engineering, “We designed and built a new robotic system inspired by nature – by the way that animals can use their bodies in different ways to achieve different types of locomotion.” For example, birds fly and then change their body morphology to slow themselves down and avoid obstacles. Mandralis adds, “Having the ability to transform in the air unlocks a lot of possibilities for improved autonomy and robustness.”

However, mid-air transformation also poses challenges due to complex aerodynamic forces that come into play both because the robot is close to the ground and because it is changing its shape as it morphs. Mory Gharib, the Hans W. Liepmann Professor of Aeronautics and Medical Engineering, notes that “Even though it seems simple when you watch a bird land and then run, in reality this is a problem that the aerospace industry has been struggling to deal with for probably more than 50 years.”

To better understand these complex aerodynamic forces, the researchers ran tests in Caltech’s drone lab using load cell experiments and smoke visualization. They fed those insights into the algorithm behind a new control system they created for ATMO, which uses advanced model predictive control to continuously predict how the system will behave in the near future and adjust its actions accordingly.

“The control algorithm is the biggest innovation in this paper,” Mandralis says. “Quadrotors use particular controllers because of how their thrusters are placed and how they fly. Here we introduce a dynamic system that hasn’t been studied before. As soon as the robot starts morphing, you get different dynamic couplings – different forces interacting with one another. And the control system has to be able to respond quickly to all of that.”

The potential applications of ATMO are vast and exciting, from commercial delivery systems to robotic explorers. With its unique ability to transform in mid-air and adapt to various environments, this technology has the potential to revolutionize the field of robotics and beyond.

Researchers at the University of California, Irvine (UCI) have made a groundbreaking discovery in the field of materials science. By expanding on a classic model developed over 70 years ago, scientists in UCI’s Samueli School of Engineering have gained new insights into the behavior of advanced materials critical to energy systems, space exploration, and nuclear applications.

The traditional Frank-Read theory attributed slip band formation to continuous dislocation multiplication at active sources. However, the UC Irvine team found that extended slip bands emerge from source deactivation followed by the dynamic activation of new dislocation sources. This process was observed at the atomic scale through mechanical compression on micropillars made of a chromium-cobalt-nickel alloy.

Using advanced microscopy techniques and large-scale atomistic modeling, researchers were able to visualize the confined slip band as a thin glide zone with minimal defects and the extended slip band with a high density of planar defects. This understanding has shed new light on collective dislocation motion and microscopic deformation instability in advanced structural materials.

Deformation banding, where strain concentrates in local zones, is a common phenomenon in various substances and systems, including crystalline solids, metals, granular media, and even geologic faults under compressive stress. The discovery of extended slip bands challenges the classic model developed by physicists Charles Frank and Thornton Read in the 1950s.

“This foundational knowledge will accelerate the discovery of materials with tailored and predictable mechanical properties to meet the rising demand for advanced materials resilient to extreme environments across energy and aerospace sectors,” said corresponding author Penghui Cao, UC Irvine associate professor of mechanical and aerospace engineering.

The research was funded by the U.S. Department of Energy, UC Irvine, and the National Science Foundation (through the UC Irvine Center for Complex and Active Materials). The project involved graduate students, research specialists, and other professors from UCI’s Department of Mechanical and Aerospace Engineering and Department of Materials Science and Engineering.