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“Reviving Hope: New Breakthroughs in Extending Donor Heart Preservation Time”

A new discovery could mean more donor hearts are available for heart transplant, giving more people a second chance at life.

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The preservation time for donated hearts has always been a challenge in heart transplantation. A recent discovery by Mayo Clinic researchers has shed new light on this issue, offering hope for more people to receive a second chance at life. In a groundbreaking study published in Nature Cardiovascular Research, a team led by cardiac surgeon Paul Tang, M.D., Ph.D., identified the biological process that contributes to donor heart injury during cold storage.

The researchers found that a drug already used to treat heart conditions can prevent this damage. The study focused on a protein inside heart cells called the mineralocorticoid receptor, which plays a crucial role in how cells respond to stress. During cold storage, they discovered that this protein undergoes liquid-liquid phase separation, causing inflammation and cell death.

This process is known as primary graft dysfunction, affecting up to 20% of recipients to varying degrees. To test whether the process could be prevented, the researchers treated donor hearts with a drug called canrenone, which blocks mineralocorticoid receptor activity.

The findings were astonishing – in human donor hearts stored beyond the typical timeframe, treatment with the drug nearly tripled their pumping strength compared to hearts stored without it. The hearts also showed better blood flow and fewer signs of cell injury. This suggests that canrenone may help extend the safe storage period for donor hearts by improving the heart’s pumping strength to increase chances of a successful transplant.

As Dr. Tang emphasized, “every additional hour of preservation can impact the likelihood of whether a donor heart can return to normal function after transplantation.” The study’s breakthroughs have far-reaching potential – similar protein clustering was observed in donor kidneys, lungs, and livers during cold storage. This implies that the same strategy may help expand transplant options across multiple organ systems.

With this new discovery, medical teams will now be able to preserve heart function for longer during storage, improve transplant outcomes, and enhance patient access to lifesaving transplants. The prospect of saving more lives has never been brighter – the preservation time for donor hearts has just gotten a whole lot longer!

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Breaking Ground in Green Energy: An Iron Oxide Catalyst for Efficient Hydrogen Production

As the world shifts toward sustainable energy sources, ‘green hydrogen’ – hydrogen produced without emitting carbon – has emerged as a leading candidate for clean power. Scientists have now developed a new iron-based catalyst that more than doubles the conversion efficiency of thermochemical green hydrogen production.

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As the world shifts toward sustainable energy sources, “green hydrogen” has emerged as a leading candidate for clean power. A collaborative research team led by Professor Hyungyu Jin and Professor Jeong Woo Han has made a significant breakthrough in developing an iron-based catalyst that more than doubles the conversion efficiency of thermochemical green hydrogen production.

Generate an image depicting a scientist holding a small, futuristic-looking device with a glowing blue screen. In the background, there’s a subtle representation of a globe with a clean energy symbol (such as wind turbines or solar panels) integrated into it. The scene should convey a sense of innovation and sustainability.

The article explains how growing concerns over fossil fuel-driven pollution and climate change have led to increased attention on hydrogen as a clean energy carrier that only emits water upon combustion. Among various hydrogen production pathways, thermochemical water splitting is considered particularly promising due to its potential for high efficiency and low environmental impact.

However, most conventional oxides used in this process suffer from the limitation of requiring extremely high temperatures to operate effectively. To address this challenge, the research team developed a novel iron-poor nickel ferrite (Fe-poor NiFe2O4, or NFO) that exhibits a distinct phase transformation mechanism enabling greater oxygen capacity even at lower temperatures.

Experimental results showed that the novel oxides achieved a water-to-hydrogen conversion efficiency of 0.528% per gram of oxides – more than double the previous best-performing material’s benchmark of 0.250%. What makes this study particularly noteworthy is not only the development of a high-efficiency catalyst but also the team’s success in unraveling the underlying mechanisms.

Using a combination of experimental techniques and computational simulations, the researchers identified the “structural active sites” within iron oxide materials that drive hydrogen production at the atomic level. They further revealed that a redox swing between two types of iron sites is directly correlated with hydrogen yield – an insight that could guide the future design of even more effective catalysts.

This research has significant implications for the development of sustainable energy sources, and it was supported by several organizations, including the Circle Foundation for Innovation Science and Technology Program, the National Research Foundation of Korea, and the Korea Institute of Materials Science.

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EV Battery Recycling Key to Future Lithium Supplies

Lightweight, powerful lithium-ion batteries are crucial for the transition to electric vehicles, and global demand for lithium is set to grow rapidly over the next 25 years. A new analysis looks at how new mining operations and battery recycling could meet that demand. Recycling could play a big role in easing supply constraints, the researchers found.

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The world’s transition to electric vehicles is driving demand for lithium, a crucial mineral used in lightweight and powerful lithium-ion batteries. A recent analysis from the University of California, Davis, has shed light on how new mining operations and battery recycling could meet this growing demand. Recycling, it turns out, plays a significant role in easing supply constraints.

“Batteries are an enormous new source of demand for lithium,” says Alissa Kendall, Ray B. Krone endowed professor of Environmental Engineering at UC Davis and senior author on the paper. “Global demand for lithium has risen dramatically – by 30% between 2022 and 2023 alone – as adoption of electric vehicles continues.”

Previous research has focused on forecasting cumulative demand over the next 30 years compared to what is known to be in the ground, says graduate student Pablo Busch, first author on the paper. However, opening a new lithium mine is a potentially billion-dollar investment that could take 10 to 15 years to begin production.

New mining proposals can be delayed or cancelled by environmental regulations and local opposition. “It’s not just about having enough lithium; it’s how fast you can extract it,” Busch notes. “Any supply disruption will slow down electric vehicle adoption, reducing mobility access and extending the operation of combustion engine vehicles and their associated carbon emissions.”

There are three main sources of usable lithium: briny water from deep underground; rocks; and sedimentary clays. Half the world’s lithium currently comes from Australia, where it is mostly mined from rock. The United States has lithium-rich brine in geothermal areas and oilfields, as well as lithium-bearing clay.

A fourth source of lithium – recycling old batteries – is still a relatively expensive process compared to mining, Kendall notes. However, modeling supply and demand shows that recycling could dramatically reduce the need for new mines. Under high-demand scenarios, up to 85 new and additional lithium deposits would need to be opened by 2050. But through policies that push the market toward smaller batteries and extensive global recycling, this number could be reduced to as few as 15 new mines.

Battery recycling has an outsize effect on the market, the researchers say. “Recycling is really important for geopolitical and environmental reasons,” Kendall notes. “If you can meet a small percentage of demand with recycling, it can have a big impact on the need for new mines.”

Timing is everything; some new mines need to open to create a flow of lithium that can be recycled. Depending on the demand scenario, recycling would make the biggest difference around 2035.

Efficiency standards for electric cars and improvements to the public charging network to reduce “range anxiety” could also moderate lithium demand by encouraging smaller cars. Additional authors include Yunzhu Chen and Prosper Ogbonna, both at UC Davis, with funding from the Heising-Simons Foundation and the ClimateWorks Foundation.

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Unveiling Electron Secrets: A Groundbreaking Experiment on the Bound Electron g-Factor in Lithium-Like Tin

Researchers present new experimental and theoretical results for the bound electron g-factor in lithium-like tin which has a much higher nuclear charge than any previous measurement. The experimental accuracy reached a level of 0.5 parts per billion. Using an enhanced interelectronic QED method, the theoretical prediction for the g-factor reached a precision of 6 parts per billion.

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Unveiling Electron Secrets: A Groundbreaking Experiment on the Bound Electron g-Factor in Lithium-Like Tin

Physicists at the Max Planck Institute for Nuclear Physics have achieved a groundbreaking experiment that pushes the limits of precision measurement. By studying the bound electron g-factor in lithium-like tin, they have made an unprecedented leap forward in our understanding of quantum electrodynamics (QED). This fundamental theory describes all electromagnetic phenomena, including light and its interactions with matter.

The researchers’ goal was to test QED’s predictions even more rigorously than ever before. They employed an enhanced interelectronic QED method, incorporating effects up to the two-loop level, which has led to a 25-fold improvement over previous calculations for the g-factor in hydrogen-like systems.

To measure the g-factor of the bound electron in lithium-like tin, the scientists utilized the cryogenic Penning trap ALPHATRAP. This sophisticated device allows precise control over the ion’s motion and spin precession. By detecting small electric signals induced by the ion’s movement and sending microwave radiation to induce spin flips, they extracted the g-factor value with remarkable accuracy.

The experimental result agrees well with the theoretical prediction within the uncertainty of the calculation. The overall accuracy achieved is 0.5 parts per billion, showcasing the precision of this experiment. This breakthrough demonstrates that scientists can continue to test QED’s predictions and push the boundaries of human knowledge in understanding the fundamental forces of nature.

The researchers’ findings have significant implications for the development of new theories and models. They demonstrate that even more precise measurements are possible with advancements in technology and theory. As a result, this experiment sets the stage for further investigations into QED phenomena, such as parity non-conserving transitions in neutral atoms and other effects.

In conclusion, this groundbreaking experiment on the bound electron g-factor in lithium-like tin has pushed the limits of precision measurement, providing new insights into QED’s predictions. The scientists’ dedication to collaborative research and innovative techniques has led to a significant leap forward in our understanding of quantum mechanics and its interactions with matter.

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