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Biology

“Reviving the Northern White Rhino: A Genome-Mapped Hope for Conservation”

The northern white rhinoceros is one of the rarest animals on Earth, with just two females left and no natural way for the species to reproduce. Now, scientists have mapped the entire genome of a northern white rhino. This represents a crucial step toward bringing the critically endangered species back from the edge using advanced reproductive technologies. The complete genome can be used as a reference to analyze the health of previously developed northern white rhinoceros stem cells. Eventually, those stem cells may be able to generate sperm and eggs to yield new rhinos.

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“Reviving the Northern White Rhino: A Genome-Mapped Hope for Conservation”

In a groundbreaking achievement, an international team of scientists has successfully mapped the entire genome of the northern white rhinoceros, one of the rarest animals on Earth. This milestone marks a crucial step towards bringing this critically endangered species back from the brink of extinction using advanced reproductive technologies.

The complete genome serves as a reference point to analyze the health of previously developed northern white rhino stem cells. These stem cells may eventually be able to generate sperm and eggs, leading to the birth of new rhinos. The genome was published in PNAS on May 13, 2025.

“This is great progress not only for white rhinos but for the entire field of animal conservation,” says co-senior author Jeanne Loring, Professor Emeritus at Scripps Research and a research fellow at the San Diego Zoo Wildlife Alliance. “We’re getting closer to being able to rescue animals that otherwise might go extinct during our lifetimes.”

The new genome was created using cutting-edge DNA sequencing and genome mapping techniques combined with cells previously collected from a male northern white rhinoceros named Angalifu, who lived at the San Diego Zoo Safari Park until his death in 2014. At the time, his skin cells were cryopreserved in the San Diego Zoo Wildlife Alliance’s Frozen Zoo.

“We layered together multiple technologies to make the most accurate genomic map possible,” says Loring. “It’s like the rhino version of the Human Genome Project.”

This new genome represents a vital tool for saving the endangered species. In 2011, Loring’s team created the first induced pluripotent stem cells from northern white rhinos. They have since created other lines of stem cells from nine different individual northern white rhinos.

Collaboration was integral to achieving this milestone, and the high-quality reference genome is a key piece of the puzzle that helps scientists understand how the stem cells are functioning and guides their next steps in the genetic rescue process.

One major hurdle has always been quality control. Without a reference genome, scientists didn’t know whether any of those stem cells had picked up harmful mutations during lab growth. In the new research, Loring’s team was able to use the new, complete genome to analyze the previously created stem cell lineages and discovered that one of the most promising lines had a large chunk of DNA missing.

“If we hadn’t built this genome, we wouldn’t have known that,” adds Loring. “We thought we had a good stem cell line, but it turns out it had a mutation that could have made it unsafe to use for reproduction. Now we can go back and screen all the others.”

The new genome also settled lingering questions about how different northern and southern white rhinos really are. Some earlier data suggested significant DNA differences that might make it risky for southern white rhinos to be implanted with northern white rhino embryos. But updated comparisons show their genomes are strikingly similar, giving scientists confidence that southern white rhinos can serve as surrogates without major complications.

For Loring, who’s been working on this project since 2007, the new genome is a symbol of what’s possible. “Now that we have their genome, we can apply all the tools we’ve developed for humans — CRISPR gene editing, reporter genes, everything — to help rescue them.”

The work sets a powerful example for other endangered species, Loring says. Efforts to save hundreds of different endangered species depend on careful biobanking like that being done by the San Diego Zoo Wildlife Alliance.

Ultimately, the goal is to grow healthy embryos and implant them into surrogate mothers, then raise the resulting calves in protected environments. It’s not Jurassic Park, Loring is quick to point out, and it doesn’t depend on gene editing or engineering.

“We’re not resurrecting a mystery species — we’re restoring one we still know intimately,” she adds. “The rhino is big, gentle and unforgettable. It’s the perfect symbol for what science can do to fight extinction.”

Animals

The Hidden Armor of Australia’s Iconic Lizards: Uncovering the Secret Bone Structures that Helped Them Thrive

Scientists have uncovered hidden bony armor—called osteoderms—beneath the skin of 29 goanna species across Australasia, a discovery that radically changes what we thought we knew about lizard evolution. Using museum specimens and advanced scanning, researchers found these structures are far more widespread than previously known, suggesting they may help with survival in harsh environments, not just offer protection. The revelation redefines how we understand lizard adaptation, ancient evolution, and the untapped potential of museum collections.

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The iconic monitor lizards of Australia, commonly known as goannas, have long been a symbol of the country’s unique wildlife. However, beneath their scaly skin lies an unexpected secret: a hidden layer of bony skin structures known as osteoderms. These structures, which were previously thought to be rare in lizards, are found in nearly half of all lizard species worldwide and may hold the key to understanding how these ancient reptiles not only survived but thrived in one of the world’s harshest environments.

A recent study published in the prestigious Zoological Journal of the Linnean Society has shed new light on the widespread presence of osteoderms in lizards. The research, which was conducted by an international team of scientists from Australia, Europe, and the United States, used cutting-edge micro-CT scanning to examine nearly 2,000 reptile specimens from major museum collections.

“We were astonished to find osteoderms in 29 Australo-Papuan monitor lizard species that had never been documented before,” said Roy Ebel, lead author and researcher at Museums Victoria Research Institute and the Australian National University. “It’s a fivefold increase in known cases among goannas.”

Osteoderms are most commonly associated with crocodiles, armadillos, and even some dinosaurs like Stegosaurus. However, their function has remained something of an evolutionary mystery. While they may provide protection, scientists now suspect that osteoderms may also support heat regulation, mobility, and calcium storage during reproduction.

This new research reveals that osteoderms are far more widespread in lizards than previously thought, occurring in nearly half of all lizard species worldwide – an 85% increase on earlier estimates. The findings have significant implications for our understanding of reptile evolution and the adaptation of these ancient creatures to harsh environments.

At the heart of this discovery lies the power of museum collections. Scientific institutions like Museums Victoria Research Institute play a critical role in preserving biodiversity through time, enabling researchers to study species long after they were collected. Many of the specimens used in this study were decades, and in some cases over 120 years old, but advances in imaging technology enabled scientists to uncover new insights without harming the original material.

“What’s so exciting about this finding is that it reshapes what we thought we knew about reptile evolution,” said Dr Jane Melville, Museums Victoria Research Institute Senior Curator of Terrestrial Vertebrates. “It suggests that these skin bones may have evolved in response to environmental pressures as lizards adapted to Australia’s challenging landscapes.”

The discovery of osteoderms in monitor lizards opens up new questions about how these lizards adapted, survived, and diversified across the continent. This landmark study not only tells a new chapter in the story of Australia’s goannas but provides a powerful new dataset for exploring how skin, structure, and survival have intertwined across millions of years of evolution.

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Agriculture and Food

The Ozone Secret: Extending Mango Storage Life by 28 Days

Mango lovers and growers alike may soon rejoice: scientists at Edith Cowan University have found that a simple dip in ozonated water can drastically extend the shelf life of mangoes by up to two weeks while reducing spoilage. This technique, called aqueous ozonation, helps prevent chilling injuries that typically occur during cold storage, a long-standing challenge in mango preservation.

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The article highlights groundbreaking research conducted at Edith Cowan University, where scientists have discovered an innovative way to extend the storage life of mangoes by up to 28 days. Led by Dr Mekhala Vithana, the study reveals that dipping mangoes in ozonated water for 10 minutes before cold storage significantly reduces chilling injury and extends shelf life.

Mango lovers rejoice! The research is a game-changer for growers and traders alike, as it reduces food loss during storage and provides a longer market window. With the global demand for fruits and vegetables on the rise, this eco-friendly technology could minimize post-harvest losses of mangoes and reduce waste in Australia.

Traditionally, mangoes are stored at 13 degrees Celsius for up to 14 days, but this temperature is not cold enough to prevent chilling injury. Prolonged storage below 12.5 degrees causes physiological disorders that damage the fruit skin and lead to decreased marketability and significant food waste.

The study tested aqueous ozonation technology on Australia’s most widely produced mango variety, Kensington Pride, and found that dipping the mango in ozonated water for 10 minutes prior to cold storage at 5 degrees Celsius extended shelf life up to 28 days with much less chilling injury. This breakthrough could revolutionize the way we store mangoes and reduce food waste.

Dr Vithana emphasizes that aqueous ozonation is a cost-effective, controlled-on-site technology that can be used in commercial settings. The researchers hope to conduct further studies on other varieties of mangoes to test their responsiveness and achieve further reduction in chilling injury for extended cold storage.

As we continue to explore innovative solutions to reduce food waste, the ozone secret could hold the key to extending mango storage life by 28 days, benefiting both growers and consumers alike.

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Agriculture and Food

The Tiny Condos of Fiji’s Ant Plant: A Key to Harmonious Coexistence Among Unrelated Symbionts

High in Fiji s rainforest, the ant plant Squamellaria grows swollen tubers packed with sealed, single-door apartments. Rival ant species nest in these chambers, fertilizing their host with nutrient-rich waste while never meeting face-to-face. When researchers sliced open the walls, fatal battles erupted, confirming that the plant s compartmentalized architecture prevents war and sustains the partnership. CT scans of the tubers unveiled a meticulously isolated maze, showcasing evolution s clever fix for keeping multiple, unrelated houseguests peacefully productive.

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The Fiji ant plant, Squamellaria, has long been studied for its remarkable ability to form symbiotic relationships with ants. But what makes this relationship truly unique is the way the plant provides separate “condos” for each ant species, preventing conflicts that could arise from competition for resources. Researchers from Washington University in St. Louis and Durham University in the United Kingdom have made a groundbreaking discovery about the secrets behind this harmonious coexistence.

The study, published in Science, reveals that compartmentalization is the key to mitigating conflicts between unrelated symbionts. By creating separate chambers within its tubers, Squamellaria prevents ant colonies from coming into contact with each other, thereby reducing competition for resources and eliminating deadly conflicts.

“We were able to visualize directly what theory has long predicted – that unrelated partners would conflict by competing for host resources,” said Susanne S. Renner, senior author of the study. “But here we also have a simple, highly effective evolutionary strategy to mitigate these conflicts: compartmentalization.”

The researchers used computed-tomography scanning and 3D modeling to visualize the tubers’ internal structure and understand how the plant enables multiple ant species to live together in harmony. They found that removing the partition walls between the chambers resulted in immediate conflict and high worker mortality, emphasizing the importance of compartmentalization.

This discovery has significant implications for our understanding of symbiotic relationships and the ecology and evolution of species interactions. It highlights the remarkable ability of Squamellaria to adapt to its environment and form mutually beneficial relationships with ants, even when faced with conflicting interests.

The study’s findings also shed light on a long-standing problem in ecological theory – how unrelated partners can form long-term mutualistic relationships despite competing for host resources. By providing separate compartments, Squamellaria has evolved an effective solution to this problem, allowing multiple ant species to coexist peacefully and benefiting from each other’s presence.

In conclusion, the tiny condos of Fiji’s ant plant have unlocked a secret to harmonious coexistence among unrelated symbionts, offering new insights into the complex relationships between species.

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