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Animals

“Revolutionizing Pandemic Preparedness: The World’s Largest Bat Organoid Platform Breaks New Ground”

Until now, most research has used either generalized cell samples or organoids made from just one type of tropical fruit bat, and only from a single organ. But a breakthrough has arrived: a research team has now created the world’s most comprehensive bat organoid platform. These ‘mini-organs’ are grown from five common bat species found across Asia and Europe and represent four different organs — airway, lungs, kidneys, and small intestine.

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The world is on high alert when it comes to pandemics. More than 75% of new infectious diseases affecting humans originally come from animals, with bats being natural hosts to some of the world’s most dangerous viruses. However, until now, scientists have struggled to study these viruses inside bats due to a lack of suitable biological tools.

A breakthrough has arrived in the form of the world’s largest bat organoid platform, created by a research team led by the Institute for Basic Science (IBS) in Korea, along with international collaborators. This revolutionary platform allows scientists to grow “mini-organs” from five common bat species found across Asia and Europe, representing four different organs – airway, lungs, kidneys, and small intestine.

“This platform lets us explore how zoonotic viruses work in unprecedented detail,” said KOO Bon-Kyoung, Director of the IBS Center for Genome Engineering. “By reconstructing bat organ physiology in the lab, we can test key viruses, including SARS-CoV-2, MERS-CoV, influenza A, and hantavirus, and understand how they behave differently in various bat species and organs.”

The researchers found that each virus behaves uniquely, sometimes infecting only certain organs or bat species. For example, a virus that grew easily in one bat’s lung might fail to grow in another’s kidney. This helps explain why some viruses can jump to humans, while others remain confined to bats.

Senior Researcher KIM Hyunjoon emphasized, “This platform lets us isolate viruses, study infections, and test drugs all within one system – something you can’t do with ordinary lab cell models. By mimicking the bat’s natural environment, it boosts the accuracy and real-world value of infectious disease research.”

The team also discovered two previously unknown bat viruses directly from wild bat feces. Notably, one of these viruses could not be grown in standard cell cultures but thrived in the new bat organoids, proving just how valuable this technology is for future virus isolation.

Furthermore, by converting the organoids into a two-dimensional version, the scientists made it possible to quickly test potential antiviral drugs, like Remdesivir. These tests gave more reliable results than traditional lab methods.

This bat organoid platform marks a new era for infectious disease research, making it possible to safely and effectively study dangerous viruses in a setting that closely mirrors real life. For the first time, scientists can screen for new viruses, assess their risk, and test drugs using bat tissues from multiple species and organs.

“With these standardized and scalable bat organoids, we aim to systematically identify novel bat-origin viruses and screen antiviral candidates targeting pathogens with pandemic potential,” said Dr. CHOI Young Ki, Director of the Korea Virus Research Institute, Institute for Basic Science (IBS).

The research team envisions expanding this work into a global biobank resource that will serve as a cornerstone for both national and international biosecurity efforts. This initiative will enable deeper investigation into the viral features that drive cross-species transmission, support the development of comprehensive genetic maps of key bat species, and facilitate global preparedness. Ultimately, this platform will support efforts by health organizations, including the World Health Organization (WHO), to predict and prevent future pandemics.

Animals

Florida Cat’s Latest Catch: New Virus Discovered in Shrew

A cat named Pepper has once again helped scientists discover a new virus—this time a mysterious orthoreovirus found in a shrew. Researchers from the University of Florida, including virologist John Lednicky, identified this strain during unrelated testing and published its genome. Although once thought to be harmless, these viruses are increasingly linked to serious diseases in humans and animals. With previous discoveries also pointing to a pattern of viral emergence in wildlife, scientists stress the need for more surveillance—and Pepper remains an unlikely but reliable viral scout.

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The University of Florida’s Pepper, the pet cat who made headlines last year for discovering the first jeilongvirus found in the U.S., has done it again. This time, his keen senses have led researchers to a new strain of orthoreovirus, which is known to infect humans, white-tailed deer, bats, and other mammals.

John Lednicky, Ph.D., Pepper’s owner and a University of Florida College of Public Health and Health Professions virologist, was testing a specimen from an Everglades short-tailed shrew when he stumbled upon the new virus. The discovery came as part of his ongoing work to understand transmission of the mule deerpox virus.

Lednicky’s team published the complete genomic coding sequences for the virus they named “Gainesville shrew mammalian orthoreovirus type 3 strain UF-1” in the journal Microbiology Resource Announcements. The researchers note that while there have been rare reports of orthoreoviruses being associated with cases of encephalitis, meningitis, and gastroenteritis in children, more research is needed to understand their effects on humans.

“We need to pay attention to orthoreoviruses and know how to rapidly detect them,” Lednicky said. “There are many different mammalian orthoreoviruses, and not enough is known about this recently identified virus to be concerned.”

Pepper’s contributions to scientific discovery continue unabated. His specimen collection has led researchers to the identification of two other novel viruses found in farmed white-tailed deer, highlighting the importance of continued research into the ever-evolving world of viruses.

The discovery of new viruses is not surprising, given their propensity to constantly evolve and the sophisticated lab techniques used by researchers like Lednicky. “If you look, you’ll find,” he said. “And that’s why we keep finding all these new viruses.”

Lednicky and his team plan to conduct further research into the new virus, including serology and immunology studies to understand its potential threat to humans, wildlife, and pets.

Meanwhile, Pepper remains healthy and continues to contribute to scientific discovery through his outdoor adventures. As Lednicky said, “If you come across a dead animal, why not test it instead of just burying it? There is a lot of information that can be gained.”

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Animals

The Nano-Colors of Blue Sharks: Unveiling the Secrets of their Iconic Blue Pigmentation

Blue sharks possess a secret hidden in their skin: a sophisticated arrangement of microscopic crystals and pigments that create their brilliant blue appearance — and may allow them to change color. Scientists have discovered that these nanostructures, found inside tooth-like skin scales, act like nature’s version of layered mirrors and light filters. What’s more, changes in the spacing of these layers — possibly triggered by environmental factors like water pressure — could enable the sharks to shift their color from blue to green or gold. The discovery not only unravels a biological mystery but hints at a new frontier in bio-inspired materials with applications in sustainable design and camouflage technology.

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The research team at City University of Hong Kong has made a groundbreaking discovery in understanding the anatomy of blue sharks (Prionace glauca). Led by Dr. Viktoriia Kamska, they have revealed a unique nanostructure in the shark’s skin that produces its iconic blue coloration. This remarkable mechanism lies within the pulp cavities of the tooth-like scales – known as dermal denticles – that armor the shark’s skin.

The secret to the shark’s color lies in the combination of guanine crystals, which act as blue reflectors, and melanin-containing vesicles called melanosomes, which absorb other wavelengths. This collaboration between pigment (melanin) and structured material (guanine platelets of specific thickness and spacing) enhances color saturation.

When these components are packed together, they create a powerful ability to produce and change color. Dr. Kamska explains that the cells containing the crystals can be observed to see how they influence the color of the whole organism. This anatomical breakthrough was made possible using a range of imaging techniques, including fine-scale dissection, optical microscopy, electron microscopy, spectroscopy, and computational simulations.

The discovery also reveals that the shark’s trademark color is potentially mutable through tiny changes in the relative distances between layers of guanine crystals within the denticle pulp cavities. Increasing this space shifts the color into greens and golds. Dr. Kamska and her team have demonstrated that this structural mechanism of color change could be driven by environmental factors such as humidity or water pressure changes.

For example, the deeper a shark swims, the more pressure its skin is subjected to, which should darken the shark’s color to better suit its surroundings. The next step is to see how this mechanism really functions in sharks living in their natural environment.

This research has strong potential for bio-inspired engineering applications. Dr. Kamska notes that structural coloration reduces toxicity and environmental pollution compared to chemical coloration. It could be a tool to improve environmental sustainability within the manufacturing industry, especially in marine environments where dynamic blue camouflage would be useful.

As nanofabrication tools get better, this creates a playground to study how structures lead to new functions. The research has been presented at the Society for Experimental Biology Annual Conference in Antwerp, Belgium on July 9th, 2025, and is being funded by Hong Kong’s University Grants Committee and General Research Fund.

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Animals

The Orange Attraction: Unlocking the Secrets of Guppy Coloration

Male guppies that glow with more orange aren’t just fashion-forward — they’re also significantly more sexually active. A UBC study reveals that brighter coloration is linked to virility and is genetically tied to brain development, suggesting a deeper evolutionary function. Researchers found that these bold hues aren’t just for attracting mates, but are rooted in a vast, multi-chromosomal genetic system that enables tens of thousands of possible color pattern combinations. The work sheds light on how vibrant displays, behavior, and genetic fitness are intertwined in evolution.

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The latest research from the University of British Columbia has shed light on an intriguing phenomenon – why male guppies have such striking and varied colors and patterns. A team of zoologists, led by Drs. Wouter van der Bijl and Judith Mank, conducted a comprehensive study to investigate this evolutionary mystery.

Their findings, published in Nature Ecology & Evolution, reveal that the more orange a male guppy is, the more virile it appears to be. The researchers used a combination of deep learning, genetic studies, and selective breeding to explore this connection. They bred three generations of increasingly orange guppies, observing significant differences in behavior.

What they discovered was striking – the most colorful males were up to two times more sexually active than their less vibrant counterparts. These orange guppies performed for females at a greater rate, for longer periods, and attempted to sneakily copulate more often. This suggests that color plays a crucial role in attracting mates and showcasing genetic fitness.

Interestingly, the researchers found that female guppies have a clear preference for males with unique, orange patterns. However, what’s remarkable is that this color diversity comes from the same cells responsible for forming the brain. This genetic link implies that guppy appearance and behavior are closely tied, with more colorful individuals potentially being healthier and fitter.

The study also uncovered the vast genetic architecture behind guppy coloration. The researchers identified seven orange and eight black color types, which can combine to produce 32,768 unique pattern combinations. This staggering diversity highlights the importance of genetic variation in evolution, allowing species to adapt to changing environments and conditions, such as climate change or disease.

As Dr. van der Bijl notes, “Genetic variation is the raw material that evolution uses to produce resilient, adapted animals and plants.” This research provides valuable insights into the intricate relationships between genetics, behavior, and environment in guppies, and has broader implications for our understanding of evolutionary processes in other species as well.

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