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Chronic Illness

The Hidden Dangers of Phthalates: A Global Connection to Heart Disease Deaths

Daily exposure to certain chemicals used to make plastic household items could be linked to more than 356,000 global deaths from heart disease in 2018 alone, a new analysis of population surveys shows. While the chemicals, called phthalates, are in widespread use globally, the Middle East, South Asia, East Asia, and the Pacific bore a much larger share of the death toll than others — about three-fourths of the total.

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The article reveals a staggering connection between daily exposure to certain chemicals used in plastics and more than 356,000 global deaths from heart disease in 2018. The research, led by NYU Langone Health, focused on di-2-ethylhexyl phthalate (DEHP), a type of phthalate widely used in plastic production. Exposure to DEHP has been shown to prompt an overactive immune response in the heart’s arteries, increasing the risk of heart attack or stroke.

The study estimated that DEHP exposure contributed to 356,238 deaths, which is more than 13% of all global mortality from heart disease among men and women ages 55 through 64. The economic burden from these deaths was estimated to be around $510 billion, with a possible total impact of up to $3.74 trillion.

The research team used health and environmental data from population surveys across 200 countries and territories to estimate DEHP exposure levels. They found that the combined regions of East Asia and the Middle East, as well as East Asia and the Pacific, accounted for about 42% and 32%, respectively, of mortality from heart disease linked to DEHP exposure.

India had the highest death count at 103,587 deaths, followed by China and Indonesia. The researchers attributed this disparity to higher rates of exposure in these regions due to rapid industrialization and plastic consumption with fewer manufacturing restrictions.

The study’s findings highlight the urgent need for global regulations to reduce exposure to phthalates, especially in areas most affected by industrialization and plastic consumption. While the analysis was not designed to establish a direct causal link between DEHP and heart disease, it underscores the significant health risks associated with these chemicals.

The research team plans to track how reductions in phthalate exposure may affect global mortality rates and expand the study to other health concerns posed by the chemicals, such as preterm birth. Funding for the study was provided by National Institutes of Health grant P2CES033423 and Beyond Petrochemicals.

Artificial Intelligence

Revolutionizing Rehabilitation with Extended Reality Boccia: A Game-Changer for Older Adults

A team has developed Boccia XR, a rehabilitation program using extended reality technology that can be introduced even in environments with limited space.

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The world of sports has long been fascinated by the unique charm of boccia – a Paralympic game that transcends age and ability barriers. A team from Osaka Metropolitan University has taken this phenomenon a step further with Extended Reality (XR) Boccia, an innovative rehabilitation program that combines physical exercise with emotional benefits for older adults. Developed by Associate Professor Masataka Kataoka’s research group, XR Boccia offers a fresh alternative to traditional boccia and treadmill walking, making it perfect for environments with limited space.

The researchers conducted an intriguing study to investigate the effects of XR Boccia on participants over 65. The findings reveal that both XR Boccia and traditional boccia showed significant improvements in mood, vitality, and energy among participants after experiencing these programs. Notably, there was no substantial difference in lower limb muscle activity during any of the exercises, although a notable increase in rectus femoris muscle activity (which helps extend the knee) was observed in both types of boccia compared to treadmill walking.

The implications of this research are groundbreaking. Associate Professor Kataoka noted that XR Boccia could be an effective rehabilitation exercise for older adults, boasting both physical and emotional benefits. Given its adaptability and practicality, it’s suitable for indoor environments like hospitals and nursing care facilities. The researchers aim to further investigate long-term results in a larger population of older adults and continue updating the XR program.

The study was published in PLOS One, shedding light on this innovative approach to rehabilitation. With XR Boccia, we may be witnessing a new chapter in the journey towards better health and happiness for older adults, one game at a time.

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Apes

“Attachment Matters: A Study of Mother-Offspring Relationships in Wild Chimpanzees Reveals Insights into Human Social Behavior”

A team of researchers has identified distinct mother-offspring attachment types in wild chimpanzees (Pan troglodytes verus). Drawing parallels with human psychology, the study provides compelling evidence that wild chimpanzee infants, like human children, develop critical secure and insecure-avoidant attachment patterns to their mothers. However, unlike humans and some captive chimpanzees, wild chimpanzees did not exhibit disorganized attachment characterized by high rates of aggression. This raises new questions about how this type of attachment may be shaped by survival and modern environmental pressures.

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Attachment theory has long been recognized as a crucial factor in shaping human development. But what about our closest relatives, the chimpanzees? A four-year study of wild chimpanzees in Taï National Park, Côte d’Ivoire, has revealed that these animals develop different types of attachment to their mothers, similar to humans.

Researchers observed that some young chimpanzees felt secure and relied on their mother’s support when faced with stress or uncertainty. Others had insecure-avoidant attachments, being more independent and less likely to seek comfort from their mothers. However, unlike humans, where 23.5 percent of children show disorganized attachment, and captive orphaned chimpanzees, where 61 percent show this type of attachment, wild chimpanzees showed no signs of disorganized attachment.

This absence of disorganized attachment in wild chimpanzees is significant, as it suggests that this type of attachment may not be an adaptive survival strategy in the face of environmental constraints. In contrast to humans and captive chimpanzees, where disorganized attachment can lead to difficulties with emotional regulation, social integration, and long-term mental health problems, wild chimpanzees seem to have developed a more resilient approach to attachment.

The researchers’ findings raise important questions about modern human parenting practices. Attachment theory is a key concept in psychology that explains how early relationships shape emotional and social development. Secure attachment is associated with confidence and resilience, while insecure and disorganized attachment can be linked to anxiety, stress, or difficulties in relationships.

The study’s authors suggest that the results deepen our understanding of chimpanzees’ social development and show that humans and chimpanzees are not as different as we thought. However, they also make us think: have some modern human institutions or caregiving practices moved away from what is best for infant development?

These findings bring us closer to understanding both chimpanzees and humans, and encourage deeper reflection on how early life experiences shape social and emotional development across species. By identifying attachment patterns in wild chimpanzees, we provide important insights into the roots of human social behavior, bridging psychology, animal behavior, and anthropology.

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Asthma

Fatty Liver in Pregnancy Increases Risk of Preterm Birth, Study Finds

Pregnant women with metabolic dysfunction-associated steatotic liver disease (MASLD) have an increased risk of giving birth prematurely and the risk increase cannot be explained by obesity, according to a new study.

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Pregnant women who suffer from metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, are more likely to give birth prematurely. A new study published in the journal eClinicalMedicine has found that these women have a significantly higher risk of preterm birth, and this increased risk cannot be attributed solely to their weight or obesity.

According to the research conducted by Karolinska Institutet, one in five people in Sweden may have MASLD, while globally, it could affect as many as three out of ten individuals. Common risk factors for developing the disease include metabolic disorders like type 2 diabetes and being overweight or obese. The study’s findings are based on Swedish registry data and included a total of 240 births among women with MASLD, along with 1140 matched births from the general population.

Alarmingly, the research revealed that women with MASLD were more than three times as likely to give birth prematurely compared to those without the disease. This increased risk persisted even after adjusting for factors such as weight and metabolic disorders. The study’s lead author suggests that this association may not solely be due to a high BMI, implying that the liver disease itself could have negative effects on pregnancy outcomes.

Moreover, women with MASLD had a 63 percent higher risk of caesarean section compared to the control group. However, this increased risk seemed to be explained by their high BMI, as no significant difference was observed when comparing them to overweight or obese women without fatty liver disease.

While the study’s findings are concerning, it is essential to note that MASLD itself did not increase the risk of congenital malformations in the children born to these women. The authors acknowledge that their research may have been influenced by other factors and emphasize the importance of closely monitoring pregnant women with MASLD to reduce the risk of complications.

The study’s conclusions highlight the need for specific recommendations regarding pregnancy care for women with MASLD, which could potentially be added to clinical guidelines for managing the disease.

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