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Biology

Unlocking the Power of Thetis Cells: A Key to Understanding Childhood Food Allergies

Thetis cells, a class of immune cells first described in 2022, play an essential and previously unknown role in suppressing inflammatory responses to food, a new study finds.

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Unlocking the Power of Thetis Cells: A Key to Understanding Childhood Food Allergies

A decade ago, a groundbreaking study in the UK showed that children who were exposed to peanuts in their early months had a reduced risk of developing a peanut allergy compared to those who avoided them. Now, researchers at Memorial Sloan Kettering Cancer Center (MSK) have finally found the answer: Thetis cells.

These recently discovered immune cells play a crucial role in suppressing inflammatory responses to food, according to findings published in Science, one of the world’s premier scientific journals. The study reveals that Thetis cells are responsible for training the immune system not to overreact to food allergens – what scientists call “oral tolerance.”

This breakthrough opens new therapeutic possibilities and sheds light on why early exposure to food allergens can help train the immune system to tolerate them.

Thetis Cells Train the Immune System To Tolerate Helpful Outsiders

Thetis cells are a type of antigen-presenting cell that presents foreign substances (antigens) to other immune cells. They educate the immune system, telling it to attack foreign bacteria and viruses or to tolerate harmless proteins in food.

Previous research led by Dr. Brown identified a window in early life where a “developmental wave” of Thetis cells within the gut creates an opportunity for developing immune tolerance. This new study finds that Thetis cells not only help broker peace accords with “good” bacteria but also with proteins in foods that can act as allergens.

A Key Role for Gut-Draining Lymph Nodes

The research team used genetically engineered mouse models to investigate oral tolerance. They attached a fluorescent dye to ovalbumin, a protein found in eggs and a common allergen, to visualize which cells interacted with it.

And this showed that a subset of Thetis cells took up the protein, allowing them to program another type of immune cell called regulatory T cells to suppress the immune response to the egg protein. This process is often studied in adult models, but by examining what happens when mice first encounter food proteins at weaning, researchers could see which specific cells were critical to generating tolerance to food during early life.

Although Thetis cells can also induce tolerance throughout life, there was a significant difference in the immune response when the egg protein was introduced later.

One might imagine this as a tug-of-war between the gas pedal of the immune system and the brakes, Dr. Brown adds. When food allergens are introduced early on, it enables the body to put the brakes on the immune response much more strongly. But after this developmental wave, when far fewer Thetis cells are present, the brakes aren’t always sufficient to overcome the effects of other antigen-presenting cells that act as the gas pedal – pushing the immune system to mount inflammatory responses to foreign proteins.

New Understandings Suggest New Treatment Strategies

This new mechanistic understanding of food tolerance opens new therapeutic possibilities, Dr. Brown says.

“We’ve shown that there is a window for generating stronger tolerance, which is mediated by Thetis cells,” she says. “What this suggests is that one might develop new strategies to deliver food antigens directly to Thetis cells to promote tolerance, even though they’re rarer outside of this developmental window.”

While the current study did not examine the oral tolerance process in humans, other researchers have shown that Thetis cells in mice and humans are extremely similar.

Further, by shedding new light on how Thetis cells work and how they participate in the development of immune responses early in life, Dr. Brown and her lab are getting new insights into how they may influence the immune response to early childhood cancers.

Agriculture and Food

The Ozone Secret: Extending Mango Storage Life by 28 Days

Mango lovers and growers alike may soon rejoice: scientists at Edith Cowan University have found that a simple dip in ozonated water can drastically extend the shelf life of mangoes by up to two weeks while reducing spoilage. This technique, called aqueous ozonation, helps prevent chilling injuries that typically occur during cold storage, a long-standing challenge in mango preservation.

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The article highlights groundbreaking research conducted at Edith Cowan University, where scientists have discovered an innovative way to extend the storage life of mangoes by up to 28 days. Led by Dr Mekhala Vithana, the study reveals that dipping mangoes in ozonated water for 10 minutes before cold storage significantly reduces chilling injury and extends shelf life.

Mango lovers rejoice! The research is a game-changer for growers and traders alike, as it reduces food loss during storage and provides a longer market window. With the global demand for fruits and vegetables on the rise, this eco-friendly technology could minimize post-harvest losses of mangoes and reduce waste in Australia.

Traditionally, mangoes are stored at 13 degrees Celsius for up to 14 days, but this temperature is not cold enough to prevent chilling injury. Prolonged storage below 12.5 degrees causes physiological disorders that damage the fruit skin and lead to decreased marketability and significant food waste.

The study tested aqueous ozonation technology on Australia’s most widely produced mango variety, Kensington Pride, and found that dipping the mango in ozonated water for 10 minutes prior to cold storage at 5 degrees Celsius extended shelf life up to 28 days with much less chilling injury. This breakthrough could revolutionize the way we store mangoes and reduce food waste.

Dr Vithana emphasizes that aqueous ozonation is a cost-effective, controlled-on-site technology that can be used in commercial settings. The researchers hope to conduct further studies on other varieties of mangoes to test their responsiveness and achieve further reduction in chilling injury for extended cold storage.

As we continue to explore innovative solutions to reduce food waste, the ozone secret could hold the key to extending mango storage life by 28 days, benefiting both growers and consumers alike.

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Agriculture and Food

The Tiny Condos of Fiji’s Ant Plant: A Key to Harmonious Coexistence Among Unrelated Symbionts

High in Fiji s rainforest, the ant plant Squamellaria grows swollen tubers packed with sealed, single-door apartments. Rival ant species nest in these chambers, fertilizing their host with nutrient-rich waste while never meeting face-to-face. When researchers sliced open the walls, fatal battles erupted, confirming that the plant s compartmentalized architecture prevents war and sustains the partnership. CT scans of the tubers unveiled a meticulously isolated maze, showcasing evolution s clever fix for keeping multiple, unrelated houseguests peacefully productive.

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The Fiji ant plant, Squamellaria, has long been studied for its remarkable ability to form symbiotic relationships with ants. But what makes this relationship truly unique is the way the plant provides separate “condos” for each ant species, preventing conflicts that could arise from competition for resources. Researchers from Washington University in St. Louis and Durham University in the United Kingdom have made a groundbreaking discovery about the secrets behind this harmonious coexistence.

The study, published in Science, reveals that compartmentalization is the key to mitigating conflicts between unrelated symbionts. By creating separate chambers within its tubers, Squamellaria prevents ant colonies from coming into contact with each other, thereby reducing competition for resources and eliminating deadly conflicts.

“We were able to visualize directly what theory has long predicted – that unrelated partners would conflict by competing for host resources,” said Susanne S. Renner, senior author of the study. “But here we also have a simple, highly effective evolutionary strategy to mitigate these conflicts: compartmentalization.”

The researchers used computed-tomography scanning and 3D modeling to visualize the tubers’ internal structure and understand how the plant enables multiple ant species to live together in harmony. They found that removing the partition walls between the chambers resulted in immediate conflict and high worker mortality, emphasizing the importance of compartmentalization.

This discovery has significant implications for our understanding of symbiotic relationships and the ecology and evolution of species interactions. It highlights the remarkable ability of Squamellaria to adapt to its environment and form mutually beneficial relationships with ants, even when faced with conflicting interests.

The study’s findings also shed light on a long-standing problem in ecological theory – how unrelated partners can form long-term mutualistic relationships despite competing for host resources. By providing separate compartments, Squamellaria has evolved an effective solution to this problem, allowing multiple ant species to coexist peacefully and benefiting from each other’s presence.

In conclusion, the tiny condos of Fiji’s ant plant have unlocked a secret to harmonious coexistence among unrelated symbionts, offering new insights into the complex relationships between species.

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Biochemistry Research

The Whispering Womb: Uncovering the Secret Language of Embryonic Cells

Scientists found that embryonic skin cells “whisper” through faint mechanical tugs, using the same force-sensing proteins that make our ears ultrasensitive. By syncing these micro-movements, the cells choreograph the embryo’s shape, a dance captured with AI-powered imaging and computer models. Blocking the cells’ ability to feel the whispers stalls development, hinting that life’s first instructions are mechanical. The discovery suggests hearing hijacked an ancient force-sensing toolkit originally meant for building bodies.

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The human body begins as a single cell that multiplies and differentiates into thousands of specialized cells. Researchers at the Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN) and the Max Planck Institute have made a groundbreaking discovery: embryonic cells “listen” to each other through molecular mechanisms previously known only from hearing.

Using an interdisciplinary approach combining developmental genetics, brain research, hearing research, and theoretical physics, the researchers found that in thin layers of skin, cells register the movements of their neighboring cells and synchronize their own tiny movements with those of the others. This coordination allows groups of neighboring cells to pull together with greater force, making them highly sensitive and able to respond quickly and flexibly.

The researchers created computer models of tissue development, which showed that this “whispering” among neighboring cells leads to an intricate choreography of the entire tissue, protecting it from external forces. These findings were confirmed by video recordings of embryonic development and further experiments.

Dr. Matthias Häring, group leader at the CIDBN, explained that using AI methods and computer-assisted analysis allowed them to examine about a hundred times more cell pairs than was previously possible in this field, giving their results high accuracy.

The mechanisms revealed in embryonic development are also known to play a role in hearing, where hair cells convert sound waves into nerve signals. The ear is sensitive because of special proteins that convert mechanical forces into electrical currents. This discovery suggests that such sensors of force may have evolved from our single-celled ancestors, which emerged long before the origin of animal life.

Professor Fred Wolf, Director of the CIDBN, noted that future work should determine whether the original function of these cellular “nanomachines” was to perceive forces inside the body rather than perceiving the outside world. This phenomenon could provide insights into how force perception at a cellular level has evolved.

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