The researchers used a combination of AI and neuroscience techniques to create the digital twin. They first recorded the brain activity of real mice as they watched movies made for people, which provided a realistic representation of what the mice might see in natural settings. The films were action-packed and had a lot of movement, which strongly activated the visual system of the mice.
The researchers then used this data to train a core model, which could be customized into a digital twin of any individual mouse with additional training. These digital twins were able to closely simulate the neural activity of their biological counterparts in response to a variety of new visual stimuli, including videos and static images.
The large quantity of aggregated training data was key to the success of the digital twins, allowing them to make accurate predictions about the brain’s response to new situations. The researchers verified these predictions against high-resolution imaging of the mouse visual cortex, which provided unprecedented detail.
This technology has significant implications for the field of neuroscience. By creating a digital twin of the mouse brain, scientists can perform experiments on a realistic simulation of the brain, allowing them to gain insights into how the brain processes information and the principles of intelligence.
The researchers plan to extend their modeling into other brain areas and to animals, including primates, with more advanced cognitive capabilities. This could ultimately lead to the creation of digital twins of at least parts of the human brain, which would be a major breakthrough in the field of neuroscience.
Content:
Unlocking the Secrets of the Brain with Digital Twins
A group of researchers have created a digital twin of the mouse brain, which can predict the response of tens of thousands of neurons to new videos and images. This AI model has been trained on large datasets of brain activity collected from real mice watching movie clips.
The digital twin is an example of a foundation model, capable of learning from large datasets and applying that knowledge to new tasks and new types of data. This technology has the potential to revolutionize the field of neuroscience, allowing scientists to perform experiments on a realistic simulation of the mouse brain and gaining insights into how the brain processes information.
The researchers used a combination of AI and neuroscience techniques to create the digital twin. They first recorded the brain activity of real mice as they watched movies made for people, which provided a realistic representation of what the mice might see in natural settings. The films were action-packed and had a lot of movement, which strongly activated the visual system of the mice.
The researchers then used this data to train a core model, which could be customized into a digital twin of any individual mouse with additional training. These digital twins were able to closely simulate the neural activity of their biological counterparts in response to a variety of new visual stimuli, including videos and static images.
The large quantity of aggregated training data was key to the success of the digital twins, allowing them to make accurate predictions about the brain’s response to new situations. The researchers verified these predictions against high-resolution imaging of the mouse visual cortex, which provided unprecedented detail.
This technology has significant implications for the field of neuroscience. By creating a digital twin of the mouse brain, scientists can perform experiments on a realistic simulation of the brain, allowing them to gain insights into how the brain processes information and the principles of intelligence.
The researchers plan to extend their modeling into other brain areas and to animals, including primates, with more advanced cognitive capabilities. This could ultimately lead to the creation of digital twins of at least parts of the human brain, which would be a major breakthrough in the field of neuroscience.
Funding:
The study received funding from the Intelligence Advanced Research Projects Activity, a National Science Foundation NeuroNex grant, the National Institute of Mental Health, the National Institute of Neurological Disorders and Stroke (grant U19MH114830), the National Eye Institute (grant R01 EY026927 and Core Grant for Vision Research T32-EY-002520-37), the European Research Council and the Deutsche Forschungsgemeinschaft.