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Cats

Unveiling the Immune Response: A Breakthrough in Understanding Persistent Pathogens

Researchers show that the immune system can recognize and control the latent stage of the parasite Toxoplasma gondii, a finding that can inform the study of latency in other infections of the nervous system.

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The human body often harbors long-lasting infections, particularly in the nervous system, without causing significant disease. These microbes enter a latent stage, where they hide in cells and evade capture, playing a long game for survival. However, scientists have lacked natural models to study these quiescent stages, leading to gaps in understanding how latency contributes to pathogen persistence and whether these stages can be targeted by the immune system.

A team of researchers from the University of Pennsylvania School of Veterinary Medicine has made a significant discovery that challenges some common assumptions about how the immune system deals with infections in the brain. The study, published in Nature Microbiology, reveals that certain T cells can recognize and target neurons containing cysts of Toxoplasma gondii, which causes toxoplasmosis.

Toxoplasma gondii forms long-lived cysts in neurons in the brain, helping the parasite evade the host’s immune response. However, this study found that when these cysts are not formed, there is an even higher parasite burden and increased damage to the brain. This tradeoff suggests a delicate balance between the pathogen’s need to take hold in the host and expand without being detrimental.

Lead author Lindsey A. Shallberg explains, “There’s this balance of the pathogen needing to take hold in the host but not expand so much that it’s detrimental to the host, because if the host dies, the pathogen may not survive.”

The researchers also found that when cysts are formed, they promote mutual survival between the parasite and the host. This suggests a complex interaction between the two, where the parasite adapts to the host’s immune response, and the host adapts to the parasite’s presence.

These findings have significant implications for other infections, particularly those with latent stages in humans that do not have mouse models, such as cytomegalovirus. The study also highlights the importance of understanding how these latent stages contribute to pathogen persistence and whether they can be targeted by the immune system.

Senior author Christopher A. Hunter notes, “This knowledge supports the idea that Toxoplasma gondii cysts can be targeted and perhaps even cleared, and the findings have implications for other infections and potential future therapies.”

The study’s co-authors, Julia N. Eberhard and Sebastian Lourido, contributed to the understanding of how the parasite interacts with the host’s immune system. Aaron Winn’s mathematical modeling independently confirmed experimental findings, indicating that immune pressure on the latent stage of Toxoplasma gondii could explain the observed rise and fall in cyst numbers.

This study provides valuable insights into the complex interactions between pathogens and their hosts, shedding light on how to develop more effective treatments for infections with latent stages. As researchers continue to investigate these dynamics, they may uncover new opportunities for targeted therapies that take into account the intricate balance between pathogen and host survival.

Agriculture and Food

The Sleeping Side Preference of Cats: A Survival Strategy?

Cats overwhelmingly choose to sleep on their left side, a habit researchers say could be tied to survival. This sleep position activates the brain’s right hemisphere upon waking, perfect for detecting danger and reacting swiftly. Left-side snoozing may be more than a preference; it might be evolution’s secret trick.

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The world of cats is fascinating, especially when it comes to their sleeping habits. Researchers from Italy, Germany, Canada, Switzerland, and Turkey have made an intriguing discovery – cats prefer to sleep on their left side. This bias towards one side might seem trivial at first, but the team behind this study believes it holds a significant evolutionary advantage.

Cats are notorious for spending around 12 to 16 hours a day snoozing. They often find elevated places to rest, making it difficult for predators to access them from below. The research team, led by Dr. Sevim Isparta and Professor Onur Güntürkün, aimed to understand the behavior behind this preference. They analyzed over 400 YouTube videos featuring cats sleeping on one side or the other.

The results showed that two-thirds of these videos had cats sleeping on their left side. So, what’s the explanation? According to the researchers, when a cat sleeps on its left side and wakes up, it perceives its surroundings with its left visual field. This visual information is processed in the right hemisphere of the brain, which specializes in spatial awareness and threat processing.

This might seem like an insignificant detail, but for cats, it’s a crucial aspect of survival. By sleeping on their left side, they can quickly respond to potential threats or prey upon waking up. The researchers conclude that this preference could be a key survival strategy for cats.

The study published in the journal Current Biology provides valuable insights into the fascinating world of cat behavior and evolution. As we continue to learn more about our feline friends, we might just uncover even more surprising advantages behind their seemingly ordinary habits.

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Animals

“New Bat-Borne Viruses Discovered in China Pose Potential Pandemic Threat”

Two newly discovered viruses lurking in bats are dangerously similar to Nipah and Hendra, both of which have caused deadly outbreaks in humans. Found in fruit bats near villages, these viruses may spread through urine-contaminated fruit, raising serious concerns. And that’s just the start—scientists found 20 other unknown viruses hiding in bat kidneys.

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Scientists in China have made a groundbreaking discovery that could potentially alter our understanding of pandemics. Researchers from the Yunnan Institute of Endemic Disease Control and Prevention have found two new viruses in bats that are closely related to the deadly Nipah and Hendra viruses, which can cause severe brain inflammation and respiratory disease in humans.

The study, published in the open-access journal PLOS Pathogens, analyzed 142 bat kidneys from ten species collected over four years across five areas of Yunnan province. Using advanced genetic sequencing, the team identified 22 viruses – 20 of them never seen before. Two of these newly discovered viruses belong to the henipavirus genus, which includes Nipah and Hendra viruses known for their high fatality rates in humans.

The researchers’ findings are concerning because these henipaviruses can spread through urine, raising the risk of contaminated fruit and the possibility of the viruses jumping to humans or livestock. This highlights the importance of comprehensive microbial analyses of previously understudied organs like bat kidneys to better assess spillover risks from bat populations.

As bats are natural reservoirs for a wide range of microorganisms, including many notable pathogens that have been transmitted to humans, it is essential to conduct thorough research on these animals’ infectomes. This study not only broadens our understanding of the bat kidney infectome but also underscores critical zoonotic threats and highlights the need for comprehensive microbial analyses.

The authors emphasize that their findings raise urgent concerns about the potential for these viruses to spill over into humans or livestock, making it crucial for scientists, policymakers, and public health officials to work together to mitigate this risk. By analyzing the infectome of bat kidneys collected near village orchards and caves in Yunnan, the researchers have uncovered not only the diverse microbes bats carry but also the first full-length genomes of novel bat-borne henipaviruses closely related to Hendra and Nipah viruses identified in China.

Funding for this study came from various grants and programs, including the National Key R&D Program of China, Yunnan Revitalization Talent Support Program Top Physician Project, National Natural Science Foundation of China, and others. The funders had no role in study design, data collection, analysis, decision to publish, or preparation of the manuscript.

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Animals

Telehealth Revolutionizes Cat Care: Improving Quality of Life for Cats with Chronic Health Issues

Researchers found telehealth visits can improve care for cats with feline arthritis.

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The world of cat care is about to undergo a significant transformation. For the first time, researchers have shown that video telehealth visits can be an effective way to improve the quality of life for cats suffering from chronic health conditions. The study, conducted by a team at the University of California, Davis, involved 106 pet owners whose cats had mobility issues and found that these virtual consultations significantly benefited both cat and owner.

According to lead author Grace Boone, an assistant specialist in the UC Davis Animal Welfare Epidemiology Lab, “Teleadvice is meant to provide advice and support for caregivers caring for their cats.” The results of the study, published in Frontiers in Veterinary Science, demonstrate that video calls where pet owners can ask questions and get non-medical advice can be beneficial. In fact, more than 95% of those who took part in the research said they would pay for telehealth visits, though most were willing to pay a little less than for in-clinic appointments.

A common ailment affecting cats is feline arthritis, which affects roughly 6% to 30% of cats under age 10 and from 64% to 92% of those older than 10. As Carly Moody, senior author on the paper and an assistant animal science professor, points out, “Cats are great at hiding signs of pain.” This means that chronic health issues can go undetected for a long time if owners don’t seek veterinary care.

The researchers found that video telehealth visits allowed pet owners to receive guidance on how to modify their home environment to improve their cat’s mobility and comfort. Suggestions included elevated food and water dishes, larger litter boxes with shorter walls, and additional steps to access favorite places. Pet owners reported that the visits helped them understand their cats’ needs, making them more confident in how they cared for their cats.

Telehealth visits don’t require a veterinarian; a registered veterinary technician or other knowledgeable staff member can conduct the calls, answer questions, and give advice. These consultations are meant to supplement, not replace, in-person veterinary care. In fact, the visits have the potential to foster better veterinarian-client-patient relationships by improving communication and understanding between cat owners and veterinarians.

Future research will examine whether recommended changes based on expert advice can improve a cat’s wellbeing in the home. Additionally, Moody’s lab may explore whether telehealth could be beneficial for other health issues like obesity and disease prevention.

This article highlights the potential benefits of video telehealth visits for cats with chronic health conditions and emphasizes the importance of exploring new ways to provide care that prioritizes animal welfare.

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