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Computers & Math

Quantum Leap: Researchers Capture Embryos Using Advanced Cameras

Researchers have performed the first imaging of embryos using cameras designed for quantum measurements. The academics investigated how to best use ultrasensitive camera technology, including the latest generation of cameras that can count individual packets of light energy at each pixel, for life sciences.

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In a groundbreaking study, researchers at the University of Adelaide have successfully imaged embryos using cameras designed for quantum measurements. This innovative approach has opened up new possibilities for understanding life sciences, particularly in the field of reproductive biology.

The research team, led by Professor Kishan Dholakia, used ultrasensitive camera technology to capture images of living embryos as part of a pre-clinical trial. The goal was to minimize damage from illumination and maximize the detection of biological processes in their natural state.

“The sensitive detection of photons is vitally important for capturing biological processes in their natural state,” said Professor Dholakia, emphasizing the need for gentle light doses to avoid damaging live cells. “Modern imaging technology is very exciting with what it enables us to see.”

The team’s findings were published in APL: Photonics and demonstrate the potential of quantum-inspired cameras in life sciences research. Lead author Zane Peterkovic highlighted the challenges of imaging embryos, which require minimal light exposure to avoid damage.

“A lot of natural compounds in cells light up when illuminated, and this can tell us a lot about what we’re looking at,” said Mr. Peterkovic, “but unfortunately, the signal is very weak.” By applying quantum cameras, researchers can now get more out of their microscopes and gain valuable insights into embryonic development.

The research involved developing methods to fairly compare image quality across different cameras, as well as using AI to remove noise from captured images. The team explored how these techniques could be extended into the realm of quantum imaging, where quantum states of light may be used to further gain information about the sample.

Funding for this project was provided by the Australian Research Council. The study’s findings have significant implications for clinical IVF research and demonstrate the potential of quantum-inspired cameras in advancing life sciences research.

Air Quality

New Computer Language Unlocks Hidden Pollutants in Environmental Data

Biologists and chemists have a new programming language to uncover previously unknown environmental pollutants at breakneck speed — without requiring them to code.

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New Computer Language Unlocks Hidden Pollutants in Environmental Data

In a breakthrough for environmental science, researchers at UC Riverside have developed a programming language called Mass Query Language (MassQL) that enables biologists and chemists to quickly identify previously unknown pollutants in massive chemical datasets. This innovative tool has already helped scientists discover toxic compounds hidden in plain sight.

The power of MassQL lies in its ability to function like a search engine for mass spectrometry data, which is akin to a chemical fingerprint. By making it easier to search these vast datasets, the language allows researchers to find patterns that would otherwise require advanced programming skills. This has significant implications for environmental science, as scientists can now quickly identify pollutants in water, air, and other samples.

Developed by Mingxun Wang, an assistant professor of computer science at UC Riverside, MassQL was created to empower chemists and biologists without extensive coding experience to mine their data exactly how they want. This user-friendly approach has the potential to revolutionize environmental research, enabling scientists to quickly identify pollutants and develop strategies for removal.

One notable example of MassQL’s effectiveness is its use by Nina Zhao, a UCR postdoctoral student now at UC San Diego. She employed the language to sift through the entire world’s mass spectrometry data on water samples, searching for organophosphate esters – compounds commonly found in flame retardants. The results were staggering: MassQL pulled out thousands of measurements, including some chemicals that have not been previously described or catalogued.

These findings highlight the importance of MassQL in environmental science. By providing a powerful tool for identifying pollutants, researchers can now develop strategies to address these toxic compounds and protect human and animal health.

MassQL’s development was made possible by a collaborative effort involving over 70 scientists from various fields. This consensus-driven approach ensured that the language would be useful across multiple disciplines and real-life situations.

The potential applications of MassQL are vast, ranging from detecting fatty acids as markers of alcohol poisoning to identifying new drugs to combat antibiotic resistance. The research team has demonstrated the effectiveness of the language in a variety of scenarios, including finding forever chemicals on playgrounds.

As Wang notes, “I wanted to create one language that could handle multiple kinds of queries. And now we have. I’m excited to hear about the discoveries that could come from this.”

With MassQL, researchers can now quickly identify pollutants and develop strategies for removal, paving the way for a cleaner, healthier environment for all.

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Artificial Intelligence

Revolutionizing Rehabilitation with Extended Reality Boccia: A Game-Changer for Older Adults

A team has developed Boccia XR, a rehabilitation program using extended reality technology that can be introduced even in environments with limited space.

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The world of sports has long been fascinated by the unique charm of boccia – a Paralympic game that transcends age and ability barriers. A team from Osaka Metropolitan University has taken this phenomenon a step further with Extended Reality (XR) Boccia, an innovative rehabilitation program that combines physical exercise with emotional benefits for older adults. Developed by Associate Professor Masataka Kataoka’s research group, XR Boccia offers a fresh alternative to traditional boccia and treadmill walking, making it perfect for environments with limited space.

The researchers conducted an intriguing study to investigate the effects of XR Boccia on participants over 65. The findings reveal that both XR Boccia and traditional boccia showed significant improvements in mood, vitality, and energy among participants after experiencing these programs. Notably, there was no substantial difference in lower limb muscle activity during any of the exercises, although a notable increase in rectus femoris muscle activity (which helps extend the knee) was observed in both types of boccia compared to treadmill walking.

The implications of this research are groundbreaking. Associate Professor Kataoka noted that XR Boccia could be an effective rehabilitation exercise for older adults, boasting both physical and emotional benefits. Given its adaptability and practicality, it’s suitable for indoor environments like hospitals and nursing care facilities. The researchers aim to further investigate long-term results in a larger population of older adults and continue updating the XR program.

The study was published in PLOS One, shedding light on this innovative approach to rehabilitation. With XR Boccia, we may be witnessing a new chapter in the journey towards better health and happiness for older adults, one game at a time.

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Artificial Intelligence

Riding the Tides: Scientists Develop Simple Algorithm for Underwater Robots to Harness Ocean Currents

Engineers have taught a simple submarine robot to take advantage of turbulent forces to propel itself through water.

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Researchers at Caltech have made a breakthrough in developing a simple algorithm for underwater robots to harness the power of ocean currents. Led by John Dabiri, the Centennial Professor of Aeronautics and Mechanical Engineering, the team has successfully created a system that allows small autonomous underwater vehicles (AUVs) to ride on turbulent water currents rather than fighting against them.

The researchers began by studying how jellyfish navigate through the ocean using their unique ability to traverse and plumb the depths. They outfitted these creatures with electronics and prosthetic “hats” to carry small payloads and report findings back to the surface. However, they soon realized that jellyfish do not have a brain and therefore cannot make decisions about how to navigate.

To address this limitation, Dabiri’s team developed what would be considered the equivalent of a brain for an AUV using artificial intelligence (AI). This allowed the robots to make decisions underwater and potentially take advantage of environmental flows. However, they soon discovered that AI was not the most efficient solution for their problem.

Enter Peter Gunnarson, a former graduate student who returned to Dabiri’s lab with a simpler approach. He attached an accelerometer to CARL-Bot, an AUV developed years ago as part of his work on incorporating artificial intelligence into its navigation technique. By measuring how CARL-Bot was being pushed around by vortex rings (underwater equivalents of smoke rings), Gunnarson noticed that the robot would occasionally get caught up in a vortex ring and be propelled clear across the tank.

The team then developed simple commands to help CARL-Bot detect the relative location of a vortex ring and position itself to catch a ride. Alternatively, the bot can decide to get out of the way if it does not want to be pushed by a particular vortex ring. This process involves elements of biomimicry, mimicking nature’s ability to use environmental flows for energy conservation.

Dabiri hopes to marry this work with his hybrid jellyfish project, which aims to demonstrate a similar capability to take advantage of environmental flows and move more efficiently through the water. With this breakthrough, underwater robots can now ride the tides, reducing energy expenditure and increasing their efficiency in navigating the ocean depths.

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