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Animals

Revolutionizing Drug Development with Minimal Mice: A Breakthrough in Antibody Testing

New active ingredients such as antibodies are usually tested individually in laboratory animals. Researchers have now developed a technology that can be used to test around 25 antibodies simultaneously in a single mouse. This should not only speed up the research and development pipeline for new drugs, but also hugely reduce the number of laboratory animals required.

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The development of new drugs is a complex process that requires extensive testing on animals before they can be approved for human use. Researchers at the University of Zurich have made a groundbreaking discovery that could significantly reduce the number of laboratory animals required in this process.

The team, led by Markus Seeger from the Institute of Medical Microbiology and Johannes vom Berg from the Institute of Laboratory Animal Science, has developed a technology that allows them to test up to 25 antibodies simultaneously in a single mouse. This innovation is set to speed up the research and development pipeline for new drugs while also reducing the number of laboratory animals required.

Antibodies are proteins that specifically bind to certain structures on cells or molecules. They are used in many modern medicines, including treatments for cancer, autoimmune diseases, and infectious diseases. However, testing antibodies individually in animal models is a time-consuming process that requires a large number of laboratory animals.

The new technology uses protein fragments called flycodes to mark each antibody individually. These flycodes act as barcodes, allowing researchers to separate and analyze the individual antibodies from a complex mixture. The results show that this method delivers high-quality preclinical data on the investigated antibodies, reducing the need for multiple animal tests.

One of the most significant advantages of this technology is its potential to reduce the number of laboratory animals required in drug development. According to the researchers, this new method could reduce the number of animals required by a factor of up to 100. This not only speeds up the research and development process but also contributes to reducing animal suffering.

The researchers demonstrated that their flycode technology does not compromise the efficacy of the antibodies in living organisms. They tested the antibodies against cancer cells, and the targeted accumulation worked correctly even when combined with other antibodies. The team also used flycodes to analyze the properties and data for a series of 80 drug-like synthetic biomolecules, known as sybodies.

The breakthrough has significant implications for the pharmaceutical industry, where preclinical tests account for a large proportion of animals used. By reducing the number of animal tests required, this technology can advance preclinical discovery pipelines more efficiently in the future.

Animals

The Orange Attraction: Unlocking the Secrets of Guppy Coloration

Male guppies that glow with more orange aren’t just fashion-forward — they’re also significantly more sexually active. A UBC study reveals that brighter coloration is linked to virility and is genetically tied to brain development, suggesting a deeper evolutionary function. Researchers found that these bold hues aren’t just for attracting mates, but are rooted in a vast, multi-chromosomal genetic system that enables tens of thousands of possible color pattern combinations. The work sheds light on how vibrant displays, behavior, and genetic fitness are intertwined in evolution.

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The latest research from the University of British Columbia has shed light on an intriguing phenomenon – why male guppies have such striking and varied colors and patterns. A team of zoologists, led by Drs. Wouter van der Bijl and Judith Mank, conducted a comprehensive study to investigate this evolutionary mystery.

Their findings, published in Nature Ecology & Evolution, reveal that the more orange a male guppy is, the more virile it appears to be. The researchers used a combination of deep learning, genetic studies, and selective breeding to explore this connection. They bred three generations of increasingly orange guppies, observing significant differences in behavior.

What they discovered was striking – the most colorful males were up to two times more sexually active than their less vibrant counterparts. These orange guppies performed for females at a greater rate, for longer periods, and attempted to sneakily copulate more often. This suggests that color plays a crucial role in attracting mates and showcasing genetic fitness.

Interestingly, the researchers found that female guppies have a clear preference for males with unique, orange patterns. However, what’s remarkable is that this color diversity comes from the same cells responsible for forming the brain. This genetic link implies that guppy appearance and behavior are closely tied, with more colorful individuals potentially being healthier and fitter.

The study also uncovered the vast genetic architecture behind guppy coloration. The researchers identified seven orange and eight black color types, which can combine to produce 32,768 unique pattern combinations. This staggering diversity highlights the importance of genetic variation in evolution, allowing species to adapt to changing environments and conditions, such as climate change or disease.

As Dr. van der Bijl notes, “Genetic variation is the raw material that evolution uses to produce resilient, adapted animals and plants.” This research provides valuable insights into the intricate relationships between genetics, behavior, and environment in guppies, and has broader implications for our understanding of evolutionary processes in other species as well.

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Animals

The Lemur Secret to Aging without Inflammation: A Breakthrough for Human Health?

What if humans didn’t have to suffer the slow-burning fire of chronic inflammation as we age? A surprising study on two types of lemurs found no evidence of “inflammaging,” a phenomenon long assumed to be universal among primates. These findings suggest that age-related inflammation isn’t inevitable and that environmental factors could play a far bigger role than we thought. By peering into the biology of our primate cousins, researchers are opening up new possibilities for preventing aging-related diseases in humans.

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The study of lemurs has long fascinated scientists, and a recent research breakthrough by biological anthropologist Elaine Guevara is shedding new light on the primate’s remarkable ability to age without inflammation. This phenomenon, known as “inflammaging,” is a widespread issue in humans, leading to health problems such as heart disease, strokes, diabetes, cancer, and osteoarthritis.

Guevara’s research focused on ring-tailed and sifaka lemurs, two species that differ in their life pacing and lifespan. By studying these primates, Guevara aimed to understand why they avoid the inevitability of inflammaging observed in humans. Her findings were surprising: neither species showed age-related changes in markers of oxidative stress or inflammation. In fact, ring-tailed lemurs even exhibited marginal declines in inflammation with age.

This discovery, consistent with recent studies on other non-human primates, suggests that inflamaging is not a universal feature of primates, and perhaps not even a universal feature of humans. Christine Drea, a professor of evolutionary anthropology who worked alongside Guevara, notes that this study points to differences in aging between humans and lemurs.

As we grow older, low-grade chronic inflammation sets in, causing a range of health problems. Understanding why inflamaging increases with age in humans, what causes it, and how it can be prevented is critical information for unlocking ways to help humans live longer and healthier lives. Guevara’s study serves as the first step in unraveling these questions.

The next step for Guevara and her team is to conduct similar research on lemurs in their natural habitat. This will provide valuable insights into how aging can differ between captivity and the wild, and whether inflamaging is intrinsic or environmental.

With a rapidly aging global population, these findings are essential for mitigating disability and improving quality of life in later years. Guevara’s breakthrough study offers new hope that we may be able to learn from lemurs’ remarkable ability to age without inflammation, leading to better health outcomes for humans worldwide.

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Ancient Civilizations

Unveiling North America’s Oldest Pterosaur: A Triassic Time Capsule Reveals a Diverse Ecosystem

In the remote reaches of Arizona s Petrified Forest National Park, scientists have unearthed North America’s oldest known pterosaur a small, gull-sized flier that once soared above Triassic ecosystems. This exciting find, alongside ancient turtles and armored amphibians, sheds light on a key moment in Earth’s history when older animal groups overlapped with evolutionary newcomers. The remarkably preserved fossils, including over 1,200 specimens, offer a rare glimpse into a vibrant world just before a mass extinction reshaped life on Earth.

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The discovery of North America’s oldest known pterosaur has sent shockwaves through the scientific community. A team of researchers led by paleontologist Ben Kligman has unearthed the fossilized jawbone of a new species, Eotephradactylus mcintireae, in the remote Petrified Forest National Park in Arizona. The find dates back to the late Triassic period, around 209 million years ago, and sheds light on a dynamic ecosystem where diverse groups of animals coexisted.

The Owl Rock Member, a geologic outcrop rich in volcanic ash, has allowed researchers to date the site to around 209 million years old. This makes it one of the park’s youngest rocks and provides a unique window into the Triassic period. The exposures of the Owl Rock Member are found in very remote areas, making them less studied than other geological members in the park.

The team discovered over 1,200 individual fossils, including bones, teeth, fish scales, and coprolites (fossilized poop). This assemblage contains 16 different groups of vertebrate animals that once inhabited a diverse ecosystem. The region’s braided rivers were filled with fish, like freshwater sharks and coelacanths, as well as ancient amphibians, some of which grew up to 6 feet long.

The surrounding environment was home to fearsome reptiles that evolved earlier in the Triassic, including armored herbivores and toothy predators that resembled giant crocodiles. Living alongside these strange creatures were a variety of more familiar critters, including relatives of tuataras and early frogs.

One of the most significant finds is the fossils of an ancient turtle with spike-like armor and a shell that could fit inside a shoebox. This tortoise-like animal lived around the same time as the oldest known turtle, whose fossils were previously uncovered in Germany.

The team also discovered a new species of pterosaur, which would have been small enough to comfortably perch on a person’s shoulder. The tooth-studded jaw revealed crucial clues about how the earliest pterosaurs lived. Because the tips of the teeth were worn down, the team concluded that the pterosaur likely fed on the site’s fish, many of which were encased in armor-like scales.

The bonebed is the latest research collaboration between the National Museum of Natural History and Petrified Forest National Park. Smithsonian scientists have collected petrified wood, fossils, and archaeological objects from the region since the turn of the 20th century.

This remarkable discovery has shed new light on the Triassic period and highlights the importance of continued exploration and research in our understanding of ancient ecosystems. The find also underscores the significance of preserving and protecting our natural heritage for future generations.

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