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Air Pollution

“Airborne Breakthrough: Scientists Develop Device to Detect Disease Molecules”

If you’ve ever sat waiting at the doctor’s office to give a blood sample, you might have wished there was a way to find the same information without needles. But for all the medical breakthroughs of the 20th century, the best way to detect molecules has remained through liquids, such as blood. New research, however, could someday put a pause on pinpricks. A group of scientists announced they have created a small, portable device that can collect and detect airborne molecules — a breakthrough that holds promise for many areas of medicine and public health.

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Scientists at the University of Chicago have made a groundbreaking discovery that could revolutionize the way we detect diseases. A team of researchers has developed a small, portable device called ABLE (Airborne Biomarker Localization Engine) that can collect and detect airborne molecules associated with various diseases.

The ABLE device is just four by eight inches across and is designed to capture air from its surroundings, condense it into liquid droplets, and analyze the contents for biomarkers of disease. This technology has the potential to transform the way we diagnose and monitor diseases, particularly in high-risk populations such as premature infants.

The researchers envision the ABLE device being used in various settings, including hospitals, clinics, and even homes. They believe that this technology could enable non-invasive testing for diseases like diabetes, inflammatory bowel disease, and respiratory infections.

One of the main challenges in developing the ABLE device was overcoming the problem of dilution. In air, the particles you’re looking for can be as few as one in a trillion, making it difficult to detect them using traditional methods. The researchers overcame this challenge by designing a system that captures and condenses air into liquid droplets, allowing for easier detection.

The ABLE device has already shown promise in detecting biomarkers associated with various diseases. In one test, the researchers used a cup of coffee as a proof-of-concept, blowing vaporized coffee into the device and collecting it in liquid form. The distinct aroma of coffee emanated from the liquid, demonstrating that the device can successfully detect airborne molecules.

The researchers are now working to refine the design and miniaturize the ABLE device further to make it wearable. They also plan to collaborate with medical professionals to explore the potential uses of this technology in various clinical settings.

This breakthrough has far-reaching implications for medicine and public health, and scientists are excited about the possibilities that lie ahead. As one researcher noted, “This work might start many new studies on how these airborne impurities affect phase change behaviors, and the new physics can be used for many applications.”

Air Pollution

The Persistent Pollutant: Uncovering the Mystery of Atmospheric Nitrates

A new study details processes that keep pollutants aloft despite a drop in emissions.

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The persistent presence of nitrates in the atmosphere has long been a concern for environmental scientists. Despite efforts to reduce emissions over the past few decades, nitrate levels remain stubbornly high. A recent study published in Nature Communications sheds light on this enigma, revealing that chemical processes within the atmosphere are responsible for the persistence of these pollutants.

The research team led by Hokkaido University’s Professor Yoshinori Iizuka examined nitrate deposition history from 1800 to 2020 in an ice core taken from southeastern Greenland. The results showed a gradual increase in nitrates up to the 1970s, followed by a slower decline after the 1990s. This trend mirrors the changes in emissions of nitrate precursors over the same period.

The study’s findings suggest that factors other than emission reductions are driving the persistence of atmospheric nitrates. The researchers used a global chemical transport model to investigate these factors and discovered that atmospheric acidity is the key culprit. As acidity levels rise, more nitrates become trapped in particulate form, enabling them to persist longer and travel farther.

The implications of this study are significant. Accurate measurements of particulate nitrates in ice cores provide valuable data for refining climate modeling predictions. Moreover, the findings suggest that atmospheric nitrates will soon replace sulfates as the primary aerosol in the Arctic, further amplifying warming in the region.

As Professor Iizuka notes, “Ours is the first study to present accurate information for records of particulate nitrates in ice cores.” The persistence of these pollutants highlights the importance of continued research into atmospheric chemistry and climate modeling. By understanding the complex interactions within our atmosphere, we can better predict and prepare for the challenges that lie ahead.

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Aerospace

Unveiling the Molecular Link Between Air Pollution and Pregnancy Risks: A Groundbreaking Study

A new study found exposure to specific tiny particles in air pollution during pregnancy are associated with increased risk of various negative birth outcomes.

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The air we breathe has long been a concern for public health, but a recent study by Emory University researchers sheds light on a specific and alarming link between air pollution and pregnancy risks. Published in Environmental Science & Technology, the research reveals that exposure to tiny particles in air pollution during pregnancy can disrupt maternal metabolism, leading to increased risk of various negative birth outcomes.

The study analyzed blood samples from 330 pregnant women in the Atlanta metropolitan area, providing a detailed insight into how ambient fine particulate matter (PM2.5) affects the metabolism of pregnant women and contributes to increased risks of preterm and early term births. This pioneering work marks the first time researchers have been able to investigate the specific fine particles responsible for these adverse outcomes.

“The link between air pollution and premature birth has been well established, but for the first time we were able to look at the detailed pathway and specific fine particles to identify how they are reflected in the increased risk of adverse birth outcomes,” says Donghai Liang, PhD, study lead author and associate professor of environmental health. “This is important because if we can figure out the ‘why’ and ‘how,’ then we can know better how to address it.”

Previous research has shown that pregnant women and fetuses are more vulnerable than other populations to exposure to PM2.5, which is emitted from combustion sources such as vehicle exhaust, industrial processes, and wildfires. This increased vulnerability is linked to a higher likelihood of preterm births, the leading cause of death globally among children under the age of five.

Preterm birth is associated with complications such as cerebral palsy, respiratory distress syndrome, and long-term noncommunicable disease risks. Early term births (37-39 weeks of gestation) are also linked to increased neonatal morbidity and developmental challenges. Approximately 10% of preterm births worldwide are attributable to PM2.5 exposure.

As an air pollution scientist, Liang emphasizes the importance of addressing this issue beyond simply asking people to move away from highly polluted areas. “From a clinical intervention standpoint, it’s critical to gain a better understanding on these pathways and molecules affected by pollution,” he says. “In the future, we may be able to target some of these molecules to develop effective strategies or clinical interventions that could help reduce these adverse health effects.”

This groundbreaking study highlights the urgent need for policymakers and healthcare providers to take action against air pollution, particularly in areas with high levels of PM2.5 exposure. By understanding the molecular link between air pollution and pregnancy risks, we can work towards developing targeted solutions to mitigate these negative outcomes and protect the health of future generations.

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Air Pollution

Toxic Emissions from Salton Sea Expose Communities to Hidden Health Risks

Researchers showed that hydrogen sulfide, which is associated with numerous health conditions, is emitted from California’s largest lake at levels far higher and more frequently than previously reported.

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California’s Salton Sea has been emitting high levels of hydrogen sulfide, a toxic gas that can cause headaches, nausea, fatigue, and long-term neurological and respiratory effects. A recent study found that this pollution is vastly underestimated by government air-quality monitoring systems, putting communities around the lake at risk.

The Salton Sea, located about 160 miles east of Los Angeles, has been maintained mostly by runoff from the surrounding basin since 1907. However, due to a hotter and drier climate, and policies that diverted more water away from the valley, the lake’s levels began dropping rapidly in the second half of the 20th century.

This desiccating organic matter emits hydrogen sulfide, which has been shown to cause health problems at even low levels of exposure. The researchers found that between 2013 and 2024, air quality sensors in communities surrounding the Salton Sea frequently showed hydrogen sulfide readings exceeding State of California standards.

The exceedances were most likely in the summer and most pronounced at the Torres Martinez site, which is the closest to the lake. In the month of August for each year from 2013 to 2024, Torres Martinez had an average of more than 250 hours of readings in excess of state standards.

A comparison of wind direction data confirmed that exceedances tended to happen when the wind was blowing into communities from the direction of the lake. An additional sensor placed in the shallow waters of the lake picked up consistently high hydrogen sulfide levels regardless of wind direction, helping to confirm that the lake is indeed the source of hydrogen-sulfide emissions.

The findings highlight the need for increased air-quality monitoring around the Salton Sea, as well as further study of the public health consequences of these emissions. The researchers say that community residents exposed to hydrogen sulfide are impacted not only in their physical health but also in their quality of life.

“This is a textbook case of environmental injustice,” said Aydee Palomino, project manager for the Campaign for Thriving Salton Sea Communities at Alianza Coachella Valley and a study co-author. “People in the Coachella and Imperial valleys are breathing in pollutants that are under the radar of traditional monitoring systems.”

The research was supported by Burroughs Wellcome Fund, the Google Environmental Justice Data Fund, and NASA. However, the unexpected termination of the NASA grant has disrupted planned follow-up work, including efforts to share and discuss the findings with members of the affected community.

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