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Biology

Unlocking the Power of Thetis Cells: A Key to Understanding Childhood Food Allergies

Thetis cells, a class of immune cells first described in 2022, play an essential and previously unknown role in suppressing inflammatory responses to food, a new study finds.

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Unlocking the Power of Thetis Cells: A Key to Understanding Childhood Food Allergies

A decade ago, a groundbreaking study in the UK showed that children who were exposed to peanuts in their early months had a reduced risk of developing a peanut allergy compared to those who avoided them. Now, researchers at Memorial Sloan Kettering Cancer Center (MSK) have finally found the answer: Thetis cells.

These recently discovered immune cells play a crucial role in suppressing inflammatory responses to food, according to findings published in Science, one of the world’s premier scientific journals. The study reveals that Thetis cells are responsible for training the immune system not to overreact to food allergens – what scientists call “oral tolerance.”

This breakthrough opens new therapeutic possibilities and sheds light on why early exposure to food allergens can help train the immune system to tolerate them.

Thetis Cells Train the Immune System To Tolerate Helpful Outsiders

Thetis cells are a type of antigen-presenting cell that presents foreign substances (antigens) to other immune cells. They educate the immune system, telling it to attack foreign bacteria and viruses or to tolerate harmless proteins in food.

Previous research led by Dr. Brown identified a window in early life where a “developmental wave” of Thetis cells within the gut creates an opportunity for developing immune tolerance. This new study finds that Thetis cells not only help broker peace accords with “good” bacteria but also with proteins in foods that can act as allergens.

A Key Role for Gut-Draining Lymph Nodes

The research team used genetically engineered mouse models to investigate oral tolerance. They attached a fluorescent dye to ovalbumin, a protein found in eggs and a common allergen, to visualize which cells interacted with it.

And this showed that a subset of Thetis cells took up the protein, allowing them to program another type of immune cell called regulatory T cells to suppress the immune response to the egg protein. This process is often studied in adult models, but by examining what happens when mice first encounter food proteins at weaning, researchers could see which specific cells were critical to generating tolerance to food during early life.

Although Thetis cells can also induce tolerance throughout life, there was a significant difference in the immune response when the egg protein was introduced later.

One might imagine this as a tug-of-war between the gas pedal of the immune system and the brakes, Dr. Brown adds. When food allergens are introduced early on, it enables the body to put the brakes on the immune response much more strongly. But after this developmental wave, when far fewer Thetis cells are present, the brakes aren’t always sufficient to overcome the effects of other antigen-presenting cells that act as the gas pedal – pushing the immune system to mount inflammatory responses to foreign proteins.

New Understandings Suggest New Treatment Strategies

This new mechanistic understanding of food tolerance opens new therapeutic possibilities, Dr. Brown says.

“We’ve shown that there is a window for generating stronger tolerance, which is mediated by Thetis cells,” she says. “What this suggests is that one might develop new strategies to deliver food antigens directly to Thetis cells to promote tolerance, even though they’re rarer outside of this developmental window.”

While the current study did not examine the oral tolerance process in humans, other researchers have shown that Thetis cells in mice and humans are extremely similar.

Further, by shedding new light on how Thetis cells work and how they participate in the development of immune responses early in life, Dr. Brown and her lab are getting new insights into how they may influence the immune response to early childhood cancers.

Agriculture and Food

Unlocking Nature’s Potential: Scientists Discover Key Molecule to Supercharge Plant Growth

Scientists have discovered that a molecule known for defending animal immune systems called itaconate also plays a powerful role in plants. Researchers showed that itaconate not only exists in plant cells but actively stimulates growth, such as making corn seedlings grow taller. This surprising crossover between plant and animal biology may unlock new, natural ways to boost agriculture and even improve human health.

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Unlocking Nature’s Potential: Scientists Discover Key Molecule to Supercharge Plant Growth

For years, researchers have known about a molecule called itaconate that plays a vital role in the human immune system. However, its presence and functions in plants remained largely unexplored – until now. Biologists at the University of California San Diego have conducted the first comprehensive study on itaconate’s functions in plants, revealing its significant role in stimulating plant growth.

“We found that itaconate is made in plants, particularly in growing cells,” said Jazz Dickinson, a senior author of the study and an assistant professor in the Department of Cell and Developmental Biology. “Watering maize (corn) plants with itaconate made seedlings grow taller, which was exciting and encouraged us to investigate this metabolite further and understand how it interacts with plant proteins.”

The researchers used chemical imaging and measurement techniques to confirm that plants produce itaconate. They also discovered that itaconate plays multiple key roles in plant physiology, including involvement in primary metabolism and oxygen-related stress response.

Optimizing the natural benefits of itaconate could be crucial for safely maximizing crop growth to support growing global populations. “This discovery could lead to nature-inspired solutions to improve the growth of crops, like corn,” said Dickinson. “We also hope that developing a better understanding of the connections between plant and animal biology will reveal new insights that can help both plant and human health.”

The study, supported in part by funding from the National Science Foundation and the National Institutes of Health, was published in the journal Science Advances on June 6, 2025. The findings have exciting implications for improving crop growth using nature-inspired solutions, while also offering fresh information for understanding the molecule’s role in human development and growth.

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Biology

Unveiling Ocean Giants: Scientists Discover 230 New Viruses That Hijack Photosynthesis

Scientists have uncovered over 200 new giant viruses lurking in ocean waters that not only help shape marine ecosystems but also manipulate photosynthesis in algae. These massive viruses once nearly invisible to science are now being exposed using powerful supercomputing and a new tool called BEREN. By studying these viruses, researchers hope to predict harmful algal blooms and even explore biotech applications from the novel enzymes found in these viral genomes.

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The article begins by highlighting the importance of giant viruses in the ocean, particularly their role in manipulating photosynthesis in single-celled marine organisms like algae. These protists form the base of ocean food webs, making it crucial to understand how these large DNA viruses interact with their hosts and influence marine biogeochemistry.

A recent study published in Nature npj Viruses sheds new light on this topic, using high-performance computing methods to identify 230 novel giant viruses in publicly available marine metagenomic datasets. The researchers characterized the functions of these newly discovered genomes and found that nine proteins involved in photosynthesis were present among them.

The study’s lead author, Benjamin Minch, emphasizes the significance of understanding how giant viruses interact with their hosts and manipulate cellular processes like carbon metabolism and photosynthesis. This knowledge can help predict and manage harmful algal blooms, which are human health hazards worldwide.

The researchers developed an innovative tool called BEREN (Bioinformatic tool for Eukaryotic virus Recovery from Environmental metageNomes) to identify giant virus genomes within extensive public DNA sequencing datasets. Using this tool, they recovered giant virus genomes from large global ocean sampling projects and annotated them using publicly available gene function databases.

The study’s findings fill a gap in the research field by providing an easy-to-use, one-stop tool for identifying and classifying giant viruses in sequencing datasets. The BEREN program is now available for anyone to use, offering new possibilities for monitoring pollution and pathogens in waterways.

The article concludes with the researchers’ emphasis on the importance of continued research into ocean giants and their interactions with marine ecosystems. By understanding these complex relationships, we can better predict and manage the impact of harmful algal blooms and other human health hazards associated with ocean viruses.

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Animals

Baboons’ Social Bonds Drive Their Travel Patterns, Not Survival Strategies

Researchers have discovered that baboons walk in lines, not for safety or strategy, but simply to stay close to their friends.

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Researchers at Swansea University have made an intriguing discovery about the behavior of wild chacma baboons on South Africa’s Cape Peninsula. By using high-resolution GPS tracking, they found that these intelligent primates walk in lines not for safety or strategy, but simply to stay close to their friends.

For a long time, scientists believed that baboons structured their travel patterns, known as “progressions,” to reduce risk and optimize access to food and water. However, the new study published in Behavioral Ecology reveals that this behavior is actually driven by social bonds rather than survival strategies.

The researchers analyzed 78 travel progressions over 36 days and found that the order in which individual baboons traveled was not random. They tested four potential explanations for this phenomenon, including strategic positioning to avoid danger or gain access to resources. However, their findings show that the consistent order of baboon movement patterns is solely driven by social relationships.

According to Dr. Andrew King, Associate Professor at Swansea University, “The baboons’ consistent order isn’t about avoiding danger like we see in prey animals or for better access to food or water. Instead, it’s driven by who they’re socially bonded with. They simply move with their friends, and this produces a consistent order.”
This discovery introduces the concept of a “social spandrel.” In biology, a spandrel refers to a trait that arises not because it was directly selected for but as a side effect of something else. The researchers found that the consistent travel patterns among baboons emerge naturally from their social affiliations with each other and not as an evolved strategy for safety or success.

The study highlights the importance of strong social bonds in baboon society, which are linked to longer lives and greater reproductive success. However, this research also shows that these bonds can lead to unintended consequences, such as consistent travel patterns, which serve no specific purpose but rather as a by-product of those relationships. The findings have implications for our understanding of collective animal behavior and the potential for social spandrels in other species.

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